{
  "id": 6789,
  "label": "leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005059",
  "properties": {
    "xrefs": [
      "DOID:1240",
      "EFO:0000565",
      "HP:0001909",
      "ICD9:207",
      "ICD9:207.8",
      "ICD9:207.80",
      "ICD9:208",
      "ICD9:208.8",
      "ICD9:208.80",
      "ICD9:208.9",
      "ICD9:208.90",
      "ICDO:9800/3",
      "MEDGEN:9725",
      "MESH:D007938",
      "NANDO:2100002",
      "NCIT:C3161",
      "SCTID:93143009",
      "UMLS:C0023418"
    ],
    "synonyms": [
      "blood (leukemia)",
      "leukaemia (disease)",
      "leukemia",
      "leukemia (disease)",
      "leukemia, disease",
      "leukemia, malignant",
      "leukemias",
      "leukemias, general",
      "leukaemia NOS"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 23467,
      "label": "hematopoietic and lymphoid cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025916",
          "MEDGEN:91264",
          "NCIT:C27134",
          "UMLS:C0376544"
        ],
        "synonyms": [
          "HEMOLYMPHORETICULAR tumor, malignant",
          "haematological neoplasm",
          "haematological tumour",
          "haematopoietic and lymphoid neoplasms",
          "haematopoietic cancer",
          "haematopoietic cell tumour",
          "haematopoietic malignancy, NOS",
          "haematopoietic neoplasm",
          "haematopoietic neoplasms including lymphomas",
          "haematopoietic tumour",
          "hematologic cancer",
          "hematologic malignancy",
          "hematologic neoplasm",
          "hematological neoplasm",
          "hematological tumor",
          "hematopoietic and lymphoid cell neoplasm",
          "hematopoietic and lymphoid neoplasms",
          "hematopoietic cancer",
          "hematopoietic cell tumor",
          "hematopoietic malignancy, NOS",
          "hematopoietic neoplasm",
          "hematopoietic neoplasms including lymphomas",
          "hematopoietic tumor",
          "hematopoietic, Including myeloma",
          "malignant haematopoietic neoplasm",
          "malignant hematologic neoplasm",
          "malignant hematopoietic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes."
      },
      "child_count": 8,
      "reference_id": "MONDO:0044881"
    }
  ],
  "children": [
    {
      "id": 3274,
      "label": "chronic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1036",
          "ICD9:208.10",
          "MEDGEN:220905",
          "NCIT:C3483",
          "SCTID:92812005",
          "UMLS:C1279296"
        ],
        "synonyms": [
          "chronic leukaemia (disease)",
          "chronic leukemia",
          "chronic leukemia (disease)",
          "leukaemia (disease), chronic",
          "leukemia (disease), chronic",
          "adult chronic leukaemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia."
      },
      "child_count": 8,
      "reference_id": "MONDO:0001014"
    },
    {
      "id": 3615,
      "label": "chronic erythremia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11868",
          "ICD9:207.1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001394"
    },
    {
      "id": 3695,
      "label": "testicular leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6789,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12286",
          "GARD:0022954",
          "MEDGEN:234941",
          "NCIT:C9277",
          "UMLS:C1336711"
        ],
        "synonyms": [
          "testicular leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myeloid or more commonly lymphoid leukemia (acute or chronic) affecting the testis. Microscopically, there is interstitial infiltration of the testis by leukemic cells. Acute lymphoblastic leukemia with testicular involvement is not uncommon in boys. Sometimes (up to 10% of the cases), testicular involvement may be the initial manifestation of relapsed acute lymphoblastic leukemia. --03"
      },
      "child_count": 0,
      "reference_id": "MONDO:0001482"
    },
    {
      "id": 3803,
      "label": "central nervous system leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5530,
        6789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12969",
          "GARD:0022972",
          "MEDGEN:234102",
          "NCIT:C5440",
          "UMLS:C1332884"
        ],
        "synonyms": [
          "CNS leukaemia",
          "CNS leukemia",
          "central nervous system leukaemia (disease)",
          "central nervous system leukemia",
          "central nervous system leukemia (disease)",
          "leukaemia (disease) of central nervous system",
          "leukaemia of CNS",
          "leukaemia of central nervous system",
          "leukaemia of the CNS",
          "leukaemia of the central nervous system",
          "leukemia (disease) of central nervous system",
          "leukemia of CNS",
          "leukemia of central nervous system",
          "leukemia of the CNS",
          "leukemia of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Leukemia infiltrating the central nervous system structures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001606"
    },
    {
      "id": 5610,
      "label": "aleukemic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12965",
          "DOID:6004",
          "GARD:0023635",
          "ICD9:208.80",
          "MEDGEN:164094",
          "NCIT:C4982",
          "SCTID:302856006",
          "UMLS:C0877858"
        ],
        "synonyms": [
          "aleukemic leukemia",
          "subleukemic leukaemia",
          "subleukemic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A leukemia characterized by the absence of leukemic cells in the peripheral blood."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003730"
    },
    {
      "id": 5941,
      "label": "splenic manifestation of leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789,
        7558
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:710",
          "GARD:0023828",
          "MEDGEN:234813",
          "NCIT:C7296",
          "UMLS:C1336065"
        ],
        "synonyms": [
          "leukaemia (disease) of spleen",
          "leukemia (disease) of spleen",
          "spleen leukaemia (disease)",
          "spleen leukemia (disease)",
          "splenic manifestation of leukemia",
          "splenic leukaemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A leukemia (disease) that involves the spleen."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004107"
    },
    {
      "id": 6169,
      "label": "childhood leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7757",
          "GARD:0023954",
          "MEDGEN:234132",
          "NANDO:2100002",
          "NCIT:C4989",
          "UMLS:C1332977"
        ],
        "synonyms": [
          "leukaemia",
          "leukemia",
          "childhood leukaemia (disease)",
          "childhood leukemia",
          "childhood leukemia (disease)",
          "leukaemia (disease) of childhood",
          "leukemia (disease) of childhood",
          "paediatric leukaemia (disease)",
          "pediatric leukemia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute or chronic leukemia that occurs during childhood."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004355"
    },
    {
      "id": 6392,
      "label": "monocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8527",
          "GARD:0024074",
          "ICD10CM:C93",
          "ICD9:206.8",
          "ICD9:206.80",
          "ICD9:206.81",
          "ICD9:206.90",
          "ICD9:206.91",
          "MEDGEN:109338",
          "SCTID:188744006",
          "UMLS:C0598894"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0004600"
    },
    {
      "id": 6429,
      "label": "myeloid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8692",
          "GARD:0008226",
          "ICD10CM:C92",
          "ICD9:205",
          "ICD9:205.80",
          "ICD9:205.9",
          "ICD9:205.90",
          "ICDO:9860/3",
          "MEDGEN:7320",
          "MESH:D007951",
          "NCIT:C3172",
          "SCTID:188732008",
          "UMLS:C0023470"
        ],
        "synonyms": [
          "leukaemia granulocytic",
          "leukaemia myeloid",
          "leukemia granulocytic",
          "leukemia myelogenous",
          "leukemia myeloid",
          "leukemia, granulocytic, malignant",
          "myelocytic leukaemia",
          "myelocytic leukemia",
          "myelogenous leukaemia",
          "myelogenous leukemia",
          "myeloid leukemia",
          "non-lymphoblastic leukaemia",
          "non-lymphoblastic leukemia",
          "non-lymphocytic leukaemia",
          "non-lymphocytic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004643"
    },
    {
      "id": 7079,
      "label": "lymphoid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789,
        6881
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1037",
          "DOID:10747",
          "EFO:0004289",
          "GARD:0024179",
          "HP:0005526",
          "ICD10CM:C91",
          "ICD9:204",
          "ICD9:204.2",
          "ICD9:204.20",
          "ICDO:981-983",
          "ICDO:9820/3",
          "MEDGEN:9728",
          "MESH:D007945",
          "NCIT:C7539",
          "SCTID:188726003",
          "UMLS:C0023448"
        ],
        "synonyms": [
          "leukemia, LYMPHOCYTIC, malignant",
          "lymphocytic leukemia",
          "lymphogenous leukaemia",
          "lymphogenous leukemia",
          "lymphoid leukaemia (disease)",
          "lymphoid leukemia",
          "lymphoid leukemia (disease)",
          "subacute lymphoid leukaemia",
          "subacute lymphoid leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005402"
    },
    {
      "id": 11789,
      "label": "acute leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6789,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12603",
          "EFO:1000068",
          "GARD:0024743",
          "HP:0002488",
          "ICD9:208.0",
          "ICD9:208.00",
          "ICDO:9801/3",
          "MEDGEN:43225",
          "MESH:C564112",
          "NCIT:C9300",
          "SCTID:91855006",
          "UMLS:C0085669"
        ],
        "synonyms": [
          "acute leukaemia (disease)",
          "acute leukemia",
          "acute leukemia (disease)",
          "leukemia, acute, X-linked",
          "stem cell leukaemia",
          "stem cell leukaemia (disease)",
          "stem cell leukemia",
          "stem cell leukemia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts)."
      },
      "child_count": 8,
      "reference_id": "MONDO:0010643"
    },
    {
      "id": 19803,
      "label": "mast cell leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6789,
        17076
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9254",
          "EFO:0007359",
          "GARD:0019598",
          "ICDO:9742/3",
          "MEDGEN:44123",
          "MESH:D007946",
          "MedDRA:10056450",
          "NCIT:C3169",
          "ONCOTREE:SMMCL",
          "Orphanet:158799",
          "Orphanet:98851",
          "SCTID:110002002",
          "UMLS:C0023461",
          "icd11.foundation:1359806843"
        ],
        "synonyms": [
          "Mast cell leukaemia",
          "Mast cell leukemia",
          "aleukemic mast cell leukaemia",
          "aleukemic mast cell leukemia",
          "mast-cell leukaemia",
          "mast-cell leukemia",
          "SMMCL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Mast cell leukemia is a malignant form of systemic mastocytosis (SM) characterized, most of the time, by the presence of circulating mast cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020334"
    }
  ],
  "roots": [
    {
      "id": 23467,
      "label": "hematopoietic and lymphoid cell neoplasm"
    }
  ]
}