{
  "id": 6790,
  "label": "liposarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005060",
  "properties": {
    "xrefs": [
      "DOID:3382",
      "EFO:0000569",
      "GARD:0006913",
      "ICD9:171.9",
      "ICDO:8850/3",
      "MEDGEN:44177",
      "MESH:D008080",
      "MedDRA:10024627",
      "NANDO:2200065",
      "NCIT:C3194",
      "NORD:1925",
      "ONCOTREE:LIPO",
      "Orphanet:69078",
      "SCTID:254829001",
      "UMLS:C0023827"
    ],
    "synonyms": [
      "lip sarcoma",
      "liposarcoma",
      "liposarcoma, malignant",
      "sarcoma of lip"
    ],
    "categories": [
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential is higher in less differentiated tumors."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 19,
  "parents": [
    {
      "id": 4839,
      "label": "lipomatous cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3939",
          "ICD9:171.9",
          "NCIT:C4501",
          "SCTID:254828009"
        ],
        "synonyms": [
          "adipose tissue cancer",
          "cancer of adipose tissue",
          "malignant adipose tissue neoplasm",
          "malignant adipose tissue tumor",
          "malignant adipose tissue tumour",
          "malignant lipomatous neoplasm",
          "malignant lipomatous tumor",
          "malignant lipomatous tumour",
          "malignant neoplasm of adipose tissue",
          "malignant neoplasm of the adipose tissue",
          "malignant tumor of adipose tissue",
          "malignant tumor of the adipose tissue",
          "malignant tumour of adipose tissue",
          "malignant tumour of the adipose tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant mesenchymal neoplasm arising from adipocytes."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002813"
    },
    {
      "id": 18239,
      "label": "soft tissue sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816,
        21548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070663",
          "EFO:1001968",
          "GARD:0004898",
          "MEDGEN:1642116",
          "NCIT:C9306",
          "NORD:1953",
          "Orphanet:3394",
          "SCTID:424952003",
          "UMLS:C4551687"
        ],
        "synonyms": [
          "malignant soft tissue tumor",
          "malignant soft tissue tumour",
          "connective tissue sarcoma",
          "malignant mesenchymal tumor",
          "malignant mesenchymal tumour",
          "non-Rhabdo. soft tissue sarcoma",
          "sarcoma of soft tissue",
          "sarcoma of the soft tissue",
          "soft part sarcoma",
          "soft tissue sarcoma"
        ],
        "definition": "A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones."
      },
      "child_count": 92,
      "reference_id": "MONDO:0018078"
    }
  ],
  "children": [
    {
      "id": 4685,
      "label": "liposarcoma of bone",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3381",
          "GARD:0023200",
          "MEDGEN:231450",
          "NCIT:C7598",
          "UMLS:C1332581"
        ],
        "synonyms": [
          "bone liposarcoma",
          "bone tissue liposarcoma",
          "liposarcoma of bone",
          "liposarcoma of bone tissue",
          "liposarcoma of the bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A very rare malignant adipose tissue neoplasm that arises from the bone."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002634"
    },
    {
      "id": 5480,
      "label": "adult liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5693",
          "GARD:0023569",
          "MEDGEN:75842",
          "NANDO:2200065",
          "NCIT:C7811",
          "UMLS:C0278608"
        ],
        "synonyms": [
          "liposarcoma",
          "adult liposarcoma",
          "liposarcoma of adults"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant neoplasm arising from adipocytes, that occurs in adults. The tumor maybe one of several histologic types including well-differentiated, dedifferentiated, myxoid/round cell, and pleomorphic liposarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003585"
    },
    {
      "id": 5481,
      "label": "esophagus liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3444,
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5694",
          "GARD:0023570",
          "MEDGEN:232163",
          "NCIT:C5705",
          "UMLS:C1333456"
        ],
        "synonyms": [
          "esophageal liposarcoma",
          "esophagus liposarcoma",
          "liposarcoma of esophagus",
          "liposarcoma of the esophagus",
          "liposarcoma of the oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant adipose tissue neoplasm of the esophagus, characterized by multivacuolated lipoblasts with hyperchromatic nuclei, a solid pattern of growth, and a rich vascular network. It arises from the mucosal and submucosal layers of the lower esophagus. Clinical presentation includes progressive dysphagia, nausea, throat discomfort, and foreign body sensation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003586"
    },
    {
      "id": 5482,
      "label": "pediatric liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5695",
          "GARD:0023571",
          "MEDGEN:83580",
          "NANDO:2200065",
          "NCIT:C8091",
          "UMLS:C0279984"
        ],
        "synonyms": [
          "liposarcoma",
          "childhood liposarcoma",
          "pediatric liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A rare malignant neoplasm arising from adipocytes, that occurs in children. The tumor maybe one of several histologic types including well-differentiated, dedifferentiated, myxoid/round cell, and pleomorphic liposarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003587"
    },
    {
      "id": 5483,
      "label": "larynx liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4531,
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5696",
          "GARD:0023572",
          "MEDGEN:235252",
          "NCIT:C6021",
          "UMLS:C1334372"
        ],
        "synonyms": [
          "laryngeal liposarcoma",
          "larynx liposarcoma",
          "lip larynx sarcoma",
          "liposarcoma of larynx",
          "liposarcoma of the larynx"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare malignant adipose tissue neoplasm of the larynx. It predominantly affects males. Clinical presentation includes dysphonia, dysphagia and respiratory symptoms. The supraglottis is the most common site of involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003588"
    },
    {
      "id": 5484,
      "label": "liposarcoma of the ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4344,
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5697",
          "GARD:0023573",
          "MEDGEN:233808",
          "NCIT:C6419",
          "UMLS:C1335165"
        ],
        "synonyms": [
          "liposarcoma of ovary",
          "ovarian liposarcoma",
          "ovary liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant adipose tissue neoplasm of the ovary."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003589"
    },
    {
      "id": 5485,
      "label": "fibroblastic liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5698",
          "GARD:0023574",
          "ICDO:8857/3",
          "MEDGEN:266103",
          "NCIT:C6509",
          "UMLS:C1266130"
        ],
        "synonyms": [
          "fibroblastic liposarcoma",
          "fibroblastic liposarcoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A liposarcoma characterized by the presence of a fibroblastic component."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003590"
    },
    {
      "id": 5486,
      "label": "kidney liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4936,
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5699",
          "GARD:0023575",
          "MEDGEN:235546",
          "NCIT:C6185",
          "UMLS:C1335745"
        ],
        "synonyms": [
          "kidney liposarcoma",
          "liposarcoma of kidney",
          "liposarcoma of the kidney",
          "renal liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A rare malignant adipose tissue neoplasm of the fat cells surrounding the kidney, usually of the well-differentiated or myxoid type. It may be associated with tuberous sclerosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003591"
    },
    {
      "id": 5487,
      "label": "gastric liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3312,
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5700",
          "GARD:0023576",
          "MEDGEN:272663",
          "NCIT:C5488",
          "UMLS:C1333778"
        ],
        "synonyms": [
          "gastric liposarcoma",
          "liposarcoma of stomach",
          "liposarcoma of the stomach",
          "stomach liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant adipose tissue neoplasm of the stomach."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003592"
    },
    {
      "id": 5488,
      "label": "breast liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4569,
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5701",
          "GARD:0023577",
          "MEDGEN:231968",
          "NCIT:C5187",
          "UMLS:C1332632"
        ],
        "synonyms": [
          "breast liposarcoma",
          "liposarcoma of breast",
          "liposarcoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant adipose tissue neoplasm of the breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003593"
    },
    {
      "id": 5489,
      "label": "mixed liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5703",
          "GARD:0023578",
          "ICDO:8855/3",
          "MEDGEN:87249",
          "NCIT:C4253",
          "UMLS:C0334472"
        ],
        "synonyms": [
          "mixed liposarcoma",
          "mixed liposarcoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant neoplasm characterized by the presence of a combination of liposarcomatous morphologic subtypes: myxoid/round cell and well differentiated/dedifferentiated liposarcoma or myxoid/round cell and pleomorphic liposarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003594"
    },
    {
      "id": 5493,
      "label": "vulvar liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790,
        6930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5711",
          "GARD:0023582",
          "MEDGEN:412161",
          "NCIT:C40321",
          "UMLS:C2184082"
        ],
        "synonyms": [
          "liposarcoma of mammalian vulva",
          "mammalian vulva liposarcoma",
          "vulvar liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare malignant adipose tissue neoplasm of the vulva."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003599"
    },
    {
      "id": 5494,
      "label": "cutaneous liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790,
        7932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5712",
          "GARD:0023583",
          "MEDGEN:232398",
          "NCIT:C5615",
          "UMLS:C1333175"
        ],
        "synonyms": [
          "cutaneous liposarcoma",
          "liposarcoma of skin",
          "liposarcoma of the skin",
          "liposarcoma of zone of skin",
          "skin liposarcoma",
          "zone of skin liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant adipose tissue neoplasm of the skin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003600"
    },
    {
      "id": 5495,
      "label": "mediastinum liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4866,
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5713",
          "GARD:0023584",
          "MEDGEN:233683",
          "NCIT:C6614",
          "UMLS:C1334663"
        ],
        "synonyms": [
          "lip mediastinum sarcoma",
          "liposarcoma of mediastinum",
          "liposarcoma of the mediastinum",
          "mediastinal liposarcoma",
          "mediastinum liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant adipose tissue neoplasm of the anterior, middle or posterior mediastinum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003601"
    },
    {
      "id": 5496,
      "label": "intracranial liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5714",
          "GARD:0023585",
          "MEDGEN:232663",
          "NCIT:C6973",
          "UMLS:C1334242"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant adipose tissue neoplasm of the intracranial region."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003602"
    },
    {
      "id": 6830,
      "label": "well-differentiated liposarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000736",
          "GARD:0019721",
          "ICDO:8851/3",
          "MEDGEN:237164",
          "NCIT:C4250",
          "ONCOTREE:WDLS",
          "Orphanet:99971",
          "UMLS:C1370889"
        ],
        "synonyms": [
          "atypical lipomatous tumor",
          "atypical lipomatous tumour",
          "ALT",
          "WDLS",
          "atypical lipoma",
          "well differentiated liposarcoma",
          "well differentiated liposarcoma of deep soft tissue",
          "well-differentiated liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A locally aggressive malignant neoplasm composed of mature adipocytes showing cell size variation and nuclear atypia. It is often associated with the presence of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. There are three histologic subtypes, sclerosing, inflammatory, and spindle cell liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005103"
    },
    {
      "id": 20003,
      "label": "myxoid/round cell liposarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007157",
          "MEDGEN:107784",
          "ONCOTREE:MRLS",
          "Orphanet:99967",
          "UMLS:C0545074"
        ],
        "synonyms": [
          "MRCLS",
          "myxoid/round-cell liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Myxoid/round cell liposarcoma (MRCLS) is a type of liposarcoma (LS) mostly located in the limbs, with a variable behavior depending on the histological subtype. Both myxoid and round cell are distinct histological subtypes of LS."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020561"
    },
    {
      "id": 20004,
      "label": "pleomorphic liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5702",
          "EFO:0003083",
          "GARD:0019719",
          "ICD9:171.9",
          "ICDO:8854/3",
          "MEDGEN:61457",
          "NCIT:C3705",
          "ONCOTREE:PLLS",
          "Orphanet:99969",
          "SCTID:404071006",
          "UMLS:C0205825"
        ],
        "synonyms": [
          "PLS",
          "pleomorphic liposarcoma",
          "pleomorphic liposarcoma (morphologic abnormality)",
          "PLLS"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Pleomorphic liposarcoma (PLS), the rarest subtype of liposarcoma (LS), is an aggressive, fast growing tumor located usually in the deep soft tissues of the lower and upper extremities. It is characterized by a variable number of pleomorphic lipoblasts and, in contrast to dedifferentiated liposarcoma, it lacks any association with well-differentiated liposarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020562"
    },
    {
      "id": 20005,
      "label": "dedifferentiated liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6790
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080531",
          "EFO:0003085",
          "GARD:0019720",
          "ICD9:171.9",
          "ICDO:8858/3",
          "MEDGEN:60028",
          "NCIT:C3704",
          "ONCOTREE:DDLS",
          "Orphanet:99970",
          "SCTID:404072004",
          "UMLS:C0205824"
        ],
        "synonyms": [
          "DDLPS",
          "DDLS",
          "dedifferentiated liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A high-grade subtype of liposarcoma (LS) that progresses from well-differentiated liposarcoma (WDLS), and most often occurs in the retroperitoneum. It is defined as a region of nonlipogenic sarcoma associated with WDLS."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020563"
    }
  ],
  "roots": [
    {
      "id": 4839,
      "label": "lipomatous cancer"
    },
    {
      "id": 18239,
      "label": "soft tissue sarcoma"
    }
  ]
}