{
  "id": 6791,
  "label": "lung adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005061",
  "properties": {
    "xrefs": [
      "DOID:3910",
      "EFO:0000571",
      "MEDGEN:57744",
      "MESH:C538231",
      "NCIT:C3512",
      "ONCOTREE:LUAD",
      "Orphanet:415268",
      "SCTID:254626006",
      "UMLS:C0152013"
    ],
    "synonyms": [
      "adenocarcinoma of lung",
      "adenocarcinoma of the lung",
      "lung adenocarcinoma",
      "non-small cell lung adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the lung and is characterized by the presence of malignant glandular epithelial cells. There is a male predilection with a male to female ratio of 2:1. Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding. If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever. Tobacco smoke is a known risk factor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 6944,
      "label": "non-small cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3908",
          "EFO:0003060",
          "HP:0030358",
          "MEDGEN:40104",
          "MESH:D002289",
          "NCIT:C2926",
          "ONCOTREE:NSCLC",
          "Orphanet:488201",
          "SCTID:254637007",
          "UMLS:C0007131"
        ],
        "synonyms": [
          "NSCLC",
          "NSCLC - non-small cell lung cancer",
          "non-small cell cancer of lung",
          "non-small cell cancer of the lung",
          "non-small cell carcinoma of lung",
          "non-small cell carcinoma of the lung",
          "non-small cell lung cancer",
          "non-small cell lung carcinoma",
          "non-small cell lung carcinoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005233"
    }
  ],
  "children": [
    {
      "id": 2959,
      "label": "lung adenocarcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5172,
        6444,
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050870",
          "GARD:0022780",
          "MEDGEN:1620128",
          "NCIT:C136486",
          "NCIT:C8748",
          "ONCOTREE:LAIS",
          "UMLS:C4521520"
        ],
        "synonyms": [
          "lung adenocarcinoma In situ",
          "bronchioloalveolar carcinoma",
          "adenosquamous cell carcinoma in situ of lung",
          "adenosquamous cell carcinoma in situ of the lung",
          "bronchioalveolar carcinoma",
          "in situ pulmonary adenocarcinoma",
          "lung adenosquamous cell carcinoma in situ",
          "stage 0 adenosquamous cell carcinoma of lung",
          "stage 0 adenosquamous cell carcinoma of the lung",
          "stage 0 adenosquamous cell lung carcinoma",
          "stage 0 adenosquamous lung cancer",
          "stage 0 adenosquamous lung carcinoma aJCC v6",
          "stage 0 adenosquamous lung carcinoma aJCC v6 and v7",
          "stage 0 adenosquamous lung carcinoma aJCC v7"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A localized non-invasive adenocarcinoma of the lung measuring 3 cm or less. It is characterized by a pure lepidic growth pattern and the lack of stromal, vascular, or pleural invasion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000503"
    },
    {
      "id": 2978,
      "label": "lung combined type small cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5365,
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050917",
          "GARD:0022792",
          "MEDGEN:231029",
          "NCIT:C9379",
          "UMLS:C1332165"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A lung combined type small cell carcinoma that has material basis in epithelial tissue of glandular origin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000532"
    },
    {
      "id": 5142,
      "label": "lung adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4872",
          "GARD:0023401",
          "ICD9:162.9",
          "MEDGEN:232709",
          "NCIT:C5666",
          "ONCOTREE:LUACC",
          "SCTID:707466008",
          "UMLS:C1334439"
        ],
        "synonyms": [
          "adenocystic carcinoma of lung",
          "adenocystic carcinoma of the lung",
          "adenoid cystic carcinoma of lung",
          "adenoid cystic carcinoma of the lung",
          "lung adenocystic carcinoma",
          "lung adenoid cystic cancer",
          "lung adenoid cystic carcinoma",
          "pulmonary adenocystic carcinoma",
          "pulmonary adenoid cystic carcinoma",
          "LUACC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare usually indolent lung carcinoma characterized by a cribiform and tubular pattern and the presence of glandular epithelial cells. Clinical symptoms include shortness of breath, cough, wheeze, hemopytsis and chest pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003181"
    },
    {
      "id": 5754,
      "label": "acinar lung adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6482",
          "GARD:0023717",
          "MEDGEN:233130",
          "NCIT:C5649",
          "UMLS:C1332137"
        ],
        "synonyms": [
          "acinar adenocarcinoma of lung",
          "acinar adenocarcinoma of the lung",
          "acinar lung adenocarcinoma",
          "lung acinar adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of lung adenocarcinoma characterized by the presence of acinar structures composed of columnar or cuboidal cells. (NCI05)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003892"
    },
    {
      "id": 5956,
      "label": "lung occult adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7168",
          "GARD:0023837",
          "MEDGEN:277443",
          "NCIT:C6699",
          "UMLS:C1335096"
        ],
        "synonyms": [
          "occult adenocarcinoma of the lung",
          "occult lung adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lung adenocarcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004127"
    },
    {
      "id": 6732,
      "label": "minimally invasive lung adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4926",
          "EFO:0000308",
          "GARD:0024141",
          "ICD9:162.9",
          "ICDO:8250/3",
          "ICDO:8251/3",
          "MEDGEN:2871",
          "MESH:D002282",
          "NCIT:C2923",
          "SCTID:373627005",
          "UMLS:C0007120"
        ],
        "synonyms": [
          "BAC",
          "bac",
          "bronchioalveolar adenocarcinoma of lung",
          "bronchioalveolar adenocarcinoma of the lung",
          "bronchioalveolar lung carcinoma",
          "bronchiolo-alveolar carcinoma of lung",
          "bronchiolo-alveolar carcinoma of the lung",
          "bronchiolo-alveolar lung carcinoma",
          "bronchioloalveolar adenocarcinoma of lung",
          "bronchioloalveolar adenocarcinoma of the lung",
          "bronchioloalveolar carcinoma",
          "bronchioloalveolar lung adenocarcinoma",
          "carcinoma, bronchioloalveolar, malignant",
          "minimally invasive lung adenocarcinoma",
          "bronchiolo-alveolar adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A solitary adenocarcinoma arising from the lung measuring 3 cm or less. It is characterized by a predominantly lepidic pattern and 5 mm or less invasion in greatest dimension. It is usually a non-mucinous adenocarcinoma, but rarely may be mucinous."
      },
      "child_count": 3,
      "reference_id": "MONDO:0004991"
    },
    {
      "id": 7634,
      "label": "papillary lung adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4583,
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5588",
          "EFO:1000046",
          "GARD:0024275",
          "ICD9:162.9",
          "MEDGEN:277495",
          "NCIT:C5650",
          "SCTID:707411007",
          "UMLS:C1335325"
        ],
        "synonyms": [
          "lung papillary adenocarcinoma",
          "lung papillary-adenocarcinoma",
          "papillary adenocarcinoma of lung",
          "papillary adenocarcinoma of the lung",
          "papillary lung adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of lung adenocarcinoma characterized by the presence of papillary structures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006049"
    },
    {
      "id": 7824,
      "label": "lung signet ring cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6791,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080305",
          "EFO:1000338",
          "GARD:0024359",
          "ICD9:162.9",
          "MEDGEN:310950",
          "NCIT:C45514",
          "SCTID:707407001",
          "UMLS:C1708782"
        ],
        "synonyms": [
          "lung signet ring cell carcinoma",
          "signet ring lung adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of lung adenocarcinoma characterized by the presence of signet ring cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006281"
    },
    {
      "id": 17615,
      "label": "well-differentiated fetal adenocarcinoma of the lung",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6791,
        7247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021120",
          "ICDO:8333/3",
          "MEDGEN:843585",
          "NCIT:C45509",
          "Orphanet:284395",
          "UMLS:C3873372"
        ],
        "synonyms": [
          "WDFA",
          "fetal adenocarcinoma",
          "fetal lung adenocarcinoma",
          "foetal adenocarcinoma",
          "foetal lung adenocarcinoma",
          "pulmonary adenocarcinoma of fetal type",
          "pulmonary adenocarcinoma of foetal type",
          "pulmonary endodermal tumor resembling fetal lung",
          "pulmonary endodermal tumour resembling foetal lung",
          "well-differentiated fetal lung adenocarcinoma",
          "well-differentiated foetal lung adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Well-differentiated fetal adenocarcinoma (WDFA) of the lung is a rare, primary, low-grade, bronchopulmonary neoplasm characterized by a well-circumscribed, usually large, pulmonary mass that is histologically composed of glycogen-rich neoplastic glands and tubules that resemble fetal lungs at 10 to 16 weeks of gestation and benign adjacent stroma. It typically presents with chest pain, cough, dyspnea, hemoptysis and/or generalized, non-specific symptoms, such as night sweats, lethargy, poor appetite and weight loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017292"
    },
    {
      "id": 21771,
      "label": "lung colloid adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6700,
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080303",
          "DOID:0080304",
          "GARD:0025501",
          "MEDGEN:313370",
          "NCIT:C45512",
          "UMLS:C1708776"
        ],
        "synonyms": [
          "lung colloid adenocarcinoma",
          "lung mucinous cystadenocarcinoma",
          "lung mucinous cystic tumor of borderline malignancy",
          "lung mucinous cystic tumour of borderline malignancy",
          "mucinous lung adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of lung adenocarcinoma characterized by the presence of mucin pools containing islands of well differentiated adenocarcinoma cells."
      },
      "child_count": 4,
      "reference_id": "MONDO:0027772"
    },
    {
      "id": 25151,
      "label": "solid adenocarcinoma with mucin production",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6791
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080306",
          "GARD:0026578"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850122"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 6944,
      "label": "non-small cell lung carcinoma"
    }
  ]
}