{
  "id": 6800,
  "label": "neuroblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005072",
  "properties": {
    "xrefs": [
      "DOID:769",
      "EFO:0000621",
      "GARD:0007185",
      "ICDO:9500/3",
      "MEDGEN:18012",
      "MESH:D009447",
      "MedDRA:10029260",
      "NANDO:2200040",
      "NCIT:C3270",
      "ONCOTREE:NBL",
      "Orphanet:635",
      "SCTID:432328008",
      "UMLS:C0027819",
      "birnlex:12631"
    ],
    "synonyms": [
      "neural Crest tumor, malignant",
      "neuroblastoma",
      "neuroblastoma (Schwannian Stroma-poor)",
      "neuroblastoma, malignant",
      "NB"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Neuroblastoma (NB) is the most common solid, extracranial childhood tumor. It is an aggressive pediatric cancer that originates from neural crest tissues of the sympathetic nervous system."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 7851,
      "label": "neuroblastic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7121
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000393",
          "MEDGEN:233228",
          "NCIT:C6963",
          "UMLS:C1334953"
        ],
        "synonyms": [
          "neuroblastic tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of nervous system tumors which display neuronal differentiation. It includes tumors that are composed of immature round cells and tumors that display advanced differentiation and the formation of ganglion cells."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006316"
    },
    {
      "id": 20691,
      "label": "neurocristopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20383
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "disorder of neural crest cell development",
          "disorder of neural crest development",
          "neural crest cell development disease"
        ],
        "definition": "That disease that arises from defects in the development of tissues containing cells commonly derived from the embryonic neural crest cell lineage."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021635"
    }
  ],
  "children": [
    {
      "id": 2990,
      "label": "retroperitoneal neuroblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6800,
        21554
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050937",
          "GARD:0022802",
          "MEDGEN:1843500",
          "UMLS:C2211613"
        ],
        "synonyms": [
          "neuroblastoma of retroperitoneal space",
          "retroperitoneal space neuroblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroblastoma that involves the retroperitoneal space."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000551"
    },
    {
      "id": 3347,
      "label": "mediastinum neuroblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5083,
        6800,
        7455,
        20329
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10660",
          "EFO:1000367",
          "GARD:0022879",
          "MEDGEN:235313",
          "NCIT:C6628",
          "UMLS:C1334673"
        ],
        "synonyms": [
          "mediastinum neuroblastoma",
          "neuroblastoma of mediastinum",
          "mediastinal neuroblastoma",
          "neuroblastoma of the mediastinum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroblastoma arising from the mediastinum."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001095"
    },
    {
      "id": 4784,
      "label": "extracranial neuroblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6800
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:371",
          "GARD:0023232",
          "NCIT:C5437"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroblastoma arising from an anatomic site other than the brain."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002749"
    },
    {
      "id": 4908,
      "label": "differentiating neuroblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6800
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4160",
          "GARD:0023293",
          "MEDGEN:268734",
          "NCIT:C42048",
          "UMLS:C1511934"
        ],
        "synonyms": [
          "differentiating neuroblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroblastoma in which the differentiating neuroblasts constitute more than five-percent of the tumor cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002899"
    },
    {
      "id": 4909,
      "label": "cerebral neuroblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4768,
        5116,
        6800
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080905",
          "DOID:4164",
          "GARD:0023294",
          "MEDGEN:107851",
          "NCIT:C4826",
          "SCTID:281560004",
          "UMLS:C0559458"
        ],
        "synonyms": [
          "cerebral hemispheric neuroblastoma",
          "cerebral neuroblastoma, PNET",
          "neuroblastoma of cerebral hemispheres",
          "neuroblastoma of telencephalon",
          "neuroblastoma of the cerebral hemispheres",
          "neuroblastoma of the cerebrum",
          "telencephalon neuroblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroblastoma arising from the cerebral hemispheres."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002900"
    },
    {
      "id": 7242,
      "label": "dopaminergic neuroblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6800
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006391",
          "PMID:3385588"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuroblastoma associated with increased dopamine excretion."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005598"
    },
    {
      "id": 21369,
      "label": "retinal neuroblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6800,
        20441
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025396",
          "MEDGEN:1830429",
          "NCIT:C6956",
          "UMLS:C5779888"
        ],
        "synonyms": [
          "neuroblastoma of retina",
          "neuroblastoma of the retina",
          "retina neuroblastoma",
          "retinal neuroblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A neuroblastoma arising from the retina."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024340"
    }
  ],
  "roots": [
    {
      "id": 7851,
      "label": "neuroblastic tumor"
    },
    {
      "id": 20691,
      "label": "neurocristopathy"
    }
  ]
}