{
  "id": 6803,
  "label": "thyroid gland papillary carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005075",
  "properties": {
    "xrefs": [
      "DOID:3969",
      "EFO:0000641",
      "GARD:0024148",
      "HP:0002895",
      "MEDGEN:66773",
      "NCIT:C4035",
      "ONCOTREE:THPA",
      "SCTID:255029007",
      "UMLS:C0238463"
    ],
    "synonyms": [
      "papillary cancer of the thyroid",
      "papillary cancer of the thyroid gland",
      "papillary cancer of thyroid",
      "papillary cancer of thyroid gland",
      "papillary carcinoma of the thyroid",
      "papillary carcinoma of the thyroid gland",
      "papillary carcinoma of thyroid",
      "papillary carcinoma of thyroid gland",
      "papillary thyroid cancer",
      "papillary thyroid carcinoma",
      "papillary thyroid gland carcinoma",
      "thyroid gland papillary cancer",
      "thyroid gland papillary carcinoma",
      "thyroid papillary carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4583,
      "label": "papillary adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3112",
          "ICDO:8260/3",
          "MEDGEN:123",
          "MESH:D000231",
          "NCIT:C2853",
          "UMLS:C0001420"
        ],
        "synonyms": [
          "adenocarcinoma, papillary, malignant",
          "papillary adenocarcinoma",
          "papillary adenocarcinoma (morphologic abnormality)",
          "papillary adenocarcinoma NOS (morphologic abnormality)",
          "infiltrating and papillary adenocarcinoma",
          "infiltrating papillary adenocarcinoma"
        ],
        "definition": "A morphologic variant of adenocarcinoma. It is characterized by the presence of a papillary growth pattern. Representative examples include thyroid gland papillary carcinoma, invasive papillary breast carcinoma, and ovarian serous surface papillary adenocarcinoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0002512"
    },
    {
      "id": 16290,
      "label": "differentiated thyroid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080525",
          "EFO:1002017",
          "GARD:0012027",
          "MEDGEN:277876",
          "NCIT:C7153",
          "ONCOTREE:WDTC",
          "Orphanet:146",
          "UMLS:C1337013"
        ],
        "synonyms": [
          "differentiated thyroid cancer",
          "differentiated thyroid carcinoma",
          "differentiated thyroid gland cancer",
          "differentiated thyroid gland carcinoma",
          "papillary or follicular thyroid carcinoma",
          "thyroid gland differentiated carcinoma",
          "thyroid gland well differentiated carcinoma",
          "well differentiated thyroid carcinoma",
          "well differentiated thyroid gland carcinoma",
          "well-differentiated thyroid cancer",
          "well-differentiated thyroid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Differentiated thyroid carcinoma (DTC), also known as papillary or follicular thyroid carcinoma, is a slow-growing malignancy usually presenting in adults as an asymptomatic thyroid mass."
      },
      "child_count": 3,
      "reference_id": "MONDO:0015447"
    },
    {
      "id": 21537,
      "label": "thyroid gland adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080524",
          "GARD:0025440",
          "MEDGEN:309935",
          "NCIT:C27380",
          "UMLS:C1704228"
        ],
        "synonyms": [
          "thyroid adenocarcinoma",
          "thyroid gland adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024622"
    }
  ],
  "children": [
    {
      "id": 5584,
      "label": "thyroid gland diffuse sclerosing papillary carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5914",
          "GARD:0023623",
          "ICDO:8350/3",
          "MEDGEN:87218",
          "NCIT:C7427",
          "UMLS:C0334330"
        ],
        "synonyms": [
          "nonencapsulated sclerosing adenocarcinoma",
          "nonencapsulated sclerosing carcinoma",
          "nonencapsulated sclerosing neoplasm",
          "nonencapsulated sclerosing papillary thyroid carcinoma",
          "nonencapsulated sclerosing tumor",
          "nonencapsulated sclerosing tumour",
          "thyroid gland diffuse sclerosing papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of papillary carcinoma of the thyroid gland that more often affects young patients and commonly metastasizing to the lungs. It is characterized by a diffuse infiltration of the thyroid gland by malignant follicular cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003701"
    },
    {
      "id": 5935,
      "label": "multicentric papillary thyroid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7086",
          "GARD:0023822",
          "MEDGEN:235340",
          "NCIT:C37304",
          "UMLS:C1334817"
        ],
        "synonyms": [
          "multicentric papillary thyroid carcinoma",
          "multicentric papillary thyroid gland carcinoma",
          "multicentric thyroid gland papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A papillary carcinoma arising from the thyroid gland from multiple foci."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004101"
    },
    {
      "id": 5936,
      "label": "columnar cell variant thyroid gland papillary carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7088",
          "GARD:0023823",
          "ICDO:8344/3",
          "MEDGEN:272499",
          "NCIT:C35830",
          "UMLS:C1333120"
        ],
        "synonyms": [
          "columnar cell variant papillary carcinoma",
          "columnar cell variant papillary thyroid gland carcinoma",
          "columnar cell variant thyroid gland papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of pseudostratified malignant follicular cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004102"
    },
    {
      "id": 5937,
      "label": "tall cell variant thyroid gland papillary carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7089",
          "GARD:0023824",
          "MEDGEN:234416",
          "NCIT:C35558",
          "UMLS:C1336695"
        ],
        "synonyms": [
          "tall cell variant papillary carcinoma",
          "tall cell variant thyroid gland papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of tall malignant follicular cells, arranged in papillary and trabecular patterns. Necrotic changes and high mitotic activity are present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004103"
    },
    {
      "id": 8324,
      "label": "thyroid gland papillary and follicular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6768,
        6803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3968",
          "EFO:1001083",
          "GARD:0024498",
          "MEDGEN:64631",
          "MESH:D018265",
          "NCIT:C7380",
          "UMLS:C0206683"
        ],
        "synonyms": [
          "papillary and follicular adenocarcinoma",
          "papillary and follicular carcinoma",
          "thyroid gland papillary and follicular carcinoma",
          "papillary follicular thyroid adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0006886"
    },
    {
      "id": 9854,
      "label": "thyroid cancer, nonmedullary, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6803,
        18106,
        24245
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024632",
          "MEDGEN:1648293",
          "OMIM:188550",
          "UMLS:C4721429"
        ],
        "synonyms": [
          "thyroid cancer, nonmedullary, 1",
          "thyroid cancer, nonmedullary, type 1",
          "NMTC1",
          "familial nonmedullary thyroid cancer, papillary",
          "nonmedullary thyroid carcinoma, papillary",
          "papillary carcinoma of thyroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008567"
    }
  ],
  "roots": [
    {
      "id": 4583,
      "label": "papillary adenocarcinoma"
    },
    {
      "id": 16290,
      "label": "differentiated thyroid carcinoma"
    },
    {
      "id": 21537,
      "label": "thyroid gland adenocarcinoma"
    }
  ]
}