{
  "id": 6814,
  "label": "renal cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005086",
  "properties": {
    "xrefs": [
      "DOID:4450",
      "EFO:0000681",
      "GARD:0013215",
      "HP:0005584",
      "ICD9:189.0",
      "MEDGEN:766",
      "MESH:D002292",
      "MedDRA:10067946",
      "NANDO:2200045",
      "NORD:1657",
      "ONCOTREE:RCC",
      "Orphanet:217071",
      "SCTID:702391001",
      "UMLS:C0007134"
    ],
    "synonyms": [
      "RCC",
      "renal cell carcinoma",
      "renal cell carcinoma (disease)",
      "kidney adenocarcinoma",
      "renal cell adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A carcinoma that arises from glandular epithelial cells of the kidney"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 6923,
      "label": "renal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4465,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4451",
          "EFO:0002890",
          "MEDGEN:235133",
          "NCIT:C9384",
          "UMLS:C1378703",
          "icd11.foundation:1075394530"
        ],
        "synonyms": [
          "kidney (including renal cell) cancer",
          "kidney (renal) cancer",
          "kidney cancer",
          "renal cancer",
          "carcinoma of kidney",
          "kidney carcinoma",
          "renal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005206"
    }
  ],
  "children": [
    {
      "id": 5009,
      "label": "mucinous tubular and spindle renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6814,
        20667
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4472",
          "GARD:0021418",
          "ICDO:0000/0",
          "MEDGEN:1640204",
          "NCIT:C39807",
          "ONCOTREE:MTSCC",
          "Orphanet:319322",
          "SCTID:764990003",
          "UMLS:C4707257"
        ],
        "synonyms": [
          "carcinoma, renal, tubular, malignant",
          "mucinous tubular and spindle cell carcinoma of the kidney",
          "mucinous tubular and spindle cell renal carcinoma",
          "renal mucinous tubular spindle cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A low grade carcinoma of the kidney characterized by the presence of tubules which are separated by mucinous stroma. Often the tubular structures have a spindle cell appearance. Patients are usually asymptomatic and occasionally they may present with hematuria or flank pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003011"
    },
    {
      "id": 5162,
      "label": "renal pelvis adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6814,
        7174
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4918",
          "GARD:0023410",
          "MEDGEN:277590",
          "NCIT:C6143",
          "UMLS:C1335748"
        ],
        "synonyms": [
          "adenocarcinoma of kidney pelvis",
          "adenocarcinoma of renal pelvis",
          "adenocarcinoma of the kidney pelvis",
          "adenocarcinoma of the renal pelvis",
          "kidney pelvis adenocarcinoma",
          "kidney renal pelvis adenocarcinoma",
          "renal pelvis adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the renal pelvis"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003205"
    },
    {
      "id": 5341,
      "label": "Wolffian duct adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6814,
        6877,
        7253,
        21611
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5368",
          "GARD:0023507",
          "MEDGEN:273908",
          "NCIT:C40254",
          "UMLS:C1516419"
        ],
        "synonyms": [
          "cervical mesonephric adenocarcinoma",
          "mesonephric duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A cervical adenocarcinoma that arises from mesonephric remnants. It is usually characterized by the presence of tubular glands lined by cuboidal epithelial cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003410"
    },
    {
      "id": 6935,
      "label": "collecting duct carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4464",
          "EFO:0003016",
          "GARD:0009573",
          "ICDO:8319/3",
          "MEDGEN:266092",
          "NCIT:C6194",
          "ONCOTREE:CDRCC",
          "Orphanet:247203",
          "UMLS:C1266044",
          "icd11.foundation:1481495173"
        ],
        "synonyms": [
          "BDC",
          "Bellini carcinoma",
          "Bellini duct carcinoma",
          "CDC",
          "cDC",
          "carcinoma of collecting duct of renal tubule",
          "carcinoma of collecting ducts of Bellini",
          "carcinoma of kidney collecting duct",
          "carcinoma of renal collecting duct",
          "carcinoma of the collecting ducts of Bellini",
          "carcinoma of the kidney collecting duct",
          "carcinoma of the renal collecting duct",
          "collecting duct carcinoma",
          "collecting duct of renal tubule carcinoma",
          "collecting duct renal cancer",
          "collecting duct renal cell carcinoma",
          "kidney collecting duct carcinoma",
          "renal carcinoma, collecting duct type",
          "renal collecting duct carcinoma",
          "Bellini’s duct carcinoma",
          "collecting duct carcinoma of the kidney",
          "renal medullary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the collecting duct of renal tubule"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005220"
    },
    {
      "id": 7199,
      "label": "renal cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005708",
          "GARD:0024205",
          "ICDO:8311/1",
          "ICDO:8312/3",
          "NANDO:2200045",
          "NCIT:C9385"
        ],
        "synonyms": [
          "renal cell carcinoma",
          "RCC",
          "adenocarcinoma of kidney",
          "adenocarcinoma of the kidney",
          "carcinoma, renal cell, malignant",
          "kidney adenocarcinoma",
          "renal cell adenocarcinoma",
          "renal cell cancer",
          "renal cell carcinoma, stage unspecified"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma arising from the renal parenchyma. There is a strong correlation between cigarette smoking and the development of renal cell carcinoma. The clinical presentation includes : hematuria, flank pain and a palpable lumbar mass. A high percentage of renal cell carcinomas are diagnosed when an ultrasound is performed for other purposes. Radical nephrectomy is the standard intervention procedure. Renal cell carcinoma is generally considered to be resistant to radiation treatment and chemotherapy."
      },
      "child_count": 9,
      "reference_id": "MONDO:0005549"
    },
    {
      "id": 7241,
      "label": "cystic renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006388",
          "PMID:3739121"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Cystic renal cell carcinoma includes any malignant neoplasm of renal tubular epithelium which presents as a fluid-filled mass. Approximately 15 per cent of cases of renal cell carcinoma will be cystic on radiologic and pathologic examination. The clinical features of cystic renal cell carcinoma are similar to those which are solid. The radiographic and pathologic findings of cystic renal cell carcinoma are often more confusing and less specific than the findings of renal cell carcinoma which are predominantly solid. There are four basic pathologic mechanisms resulting in cystic renal cell carcinoma: intrinsic multiloculated growth; intrinsic unilocular growth (cystadenocarcinoma); cystic necrosis; and origin from the epithelial lining of a preexisting simple cyst. There are three basic radiologic patterns of cystic renal cell carcinoma: unilocular cystic mass, multiloculated cystic mass, and discrete mural nodule in a cystic mass. Cystic renal cell carcinoma is often extremely difficult to differentiate from non-neoplastic, benign neoplastic, and other malignant neoplastic masses utilizing radiologic studies alone. This review presents the clinical, pathologic, and radiographic features of cystic renal cell carcinoma and discusses its radiologic differential diagnosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005597"
    },
    {
      "id": 7806,
      "label": "kidney medullary carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070475",
          "EFO:1000314",
          "GARD:0013175",
          "MEDGEN:888108",
          "MedDRA:10064886",
          "NCIT:C7572",
          "NORD:1999",
          "ONCOTREE:MRC",
          "Orphanet:319319",
          "UMLS:C4049328"
        ],
        "synonyms": [
          "Renal Medullary Carcinoma",
          "carcinoma of renal medulla",
          "kidney medullary carcinoma",
          "renal medulla carcinoma",
          "renal medullary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A type of renal carcinoma affecting mostly young African-Americans. It is located in the medulla of the kidney, and follows an aggressive clinical course. Most reported cases have shown metastatic disease at the time of diagnosis."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006260"
    },
    {
      "id": 8111,
      "label": "adrenal cortex carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4233,
        4840,
        6814,
        20494
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3948",
          "DOID:3959",
          "DOID:660",
          "EFO:1000796",
          "GARD:0000558",
          "HP:0006744",
          "ICDO:8370/3",
          "MEDGEN:104917",
          "MedDRA:10001388",
          "NANDO:2200073",
          "NCIT:C9325",
          "NORD:733",
          "ONCOTREE:ACC",
          "Orphanet:1501",
          "SCTID:255035007",
          "UMLS:C0206686",
          "icd11.foundation:114092945"
        ],
        "synonyms": [
          "adrenal cortex cancer",
          "adrenal cortical tumors",
          "adrenal cortical tumours",
          "adrenocortical cancer",
          "cancer of the adrenal cortex",
          "malignant adrenocortical tumor",
          "malignant adrenocortical tumour",
          "malignant neoplasm of adrenal cortex",
          "malignant tumor of adrenal cortex",
          "malignant tumour of adrenal cortex",
          "ACC",
          "Adenoid Cystic Carcinoma",
          "adenocarcinoma, adrenocortical, malignant",
          "adrenal cortex adenocarcinoma",
          "adrenal cortex carcinoma",
          "adrenal cortical adenocarcinoma",
          "adrenal cortical carcinoma",
          "adrenal cortical carcinoma (morphologic abnormality)",
          "adrenocortical carcinoma",
          "adrenocortical carcinoma (disease)",
          "carcinoma of adrenal cortex",
          "carcinoma of the adrenal cortex",
          "carcinoma, adrenocortical, malignant",
          "cortical cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells. Symptoms are usually related to the excessive production of hormones, and include Cushing's syndrome and virilism in women. Common sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced radiologic procedures have enabled the detection of small tumors, resulting in the improvement of the 5-year survival."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006639"
    },
    {
      "id": 9112,
      "label": "nonpapillary renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050387",
          "GARD:0024575",
          "OMIM:144700"
        ],
        "synonyms": [
          "renal cell carcinoma",
          "renal carcinoma, chromophobe, somatic",
          "renal cell carcinoma, clear cell",
          "renal cell carcinoma, clear cell, somatic",
          "renal cell carcinoma, somatic",
          "CCRCC",
          "clear cell renal cell adenocarcinoma",
          "clear cell renal cell carcinoma",
          "RCC",
          "adenocarcinoma of kidney",
          "hypernephroma",
          "nonpapillary renal carcinoma 1 locus",
          "renal cell carcinoma, nonpapillary"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0007763"
    },
    {
      "id": 18099,
      "label": "MIT family translocation renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081413",
          "GARD:0017446",
          "MEDGEN:1376834",
          "NCIT:C154494",
          "Orphanet:319308",
          "SCTID:764694005",
          "UMLS:C4518356"
        ],
        "synonyms": [
          "carcinoma associated with MITF/TFE translocation",
          "translocation renal cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "MiT family translocation renal cell carcinoma (t-RCC) is a rare subtype of renal cell carcinoma with recurrent genetic abnormalities, harboring rearrangements of the TFE3 (Xp11 t-RCC) or TFEB [t(6;11) t-RCC] genes. The t(6;11) t-RCC has distinctive histologic features of biphasic appearance with larger epitheloid and smaller eosinophilic cells. The symptoms are usually non-specific and include hematuria, flank pain, palpable abdominal mass and/or systemic symptoms of anemia, fatigue and fever."
      },
      "child_count": 3,
      "reference_id": "MONDO:0017886"
    },
    {
      "id": 18495,
      "label": "acquired cystic disease-associated renal cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6814
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021722",
          "MEDGEN:1644241",
          "NCIT:C157718",
          "Orphanet:404514",
          "UMLS:C4707179"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Acquired cystic disease-associated renal cell carcinoma is a rare subtype of renal cell carcinoma, occurring in the context of end-stage kidney disease and acquired cystic kidney disease, characterized by a usually well circumscribed, solid, multifocal, bilateral tumor with inter- or intracellular microlumen formation (leading to cribiform architecture). Tumors are often diagnosed incidentally in early stages, although complications caused by renal cysts (dull flank or abdominal pain, fever) or renal parenchymal bleeding may mask the underlying neoplastic process. Most have an indolent behavior."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018449"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 6923,
      "label": "renal carcinoma"
    }
  ]
}