{
  "id": 6817,
  "label": "schizophrenia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005090",
  "properties": {
    "xrefs": [
      "DOID:5419",
      "HP:0100753",
      "ICD10CM:F20",
      "ICD10WHO:F20",
      "ICD9:295",
      "ICD9:295.8",
      "ICD9:295.80",
      "ICD9:295.85",
      "ICD9:295.9",
      "ICD9:295.90",
      "MEDGEN:48574",
      "NCIT:C3362",
      "OMIM:181500",
      "Orphanet:3140",
      "SCTID:58214004",
      "UMLS:C0036341",
      "birnlex:2104",
      "icd11.foundation:1683919430"
    ],
    "synonyms": [
      "schizophrenia 12",
      "schizophrenia",
      "schizophrenia (disease)",
      "SCZD",
      "schizoaffective disorder",
      "schizophrenia with or without an affective disorder",
      "schizophrenia, susceptibility to"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 18,
  "parents": [
    {
      "id": 7141,
      "label": "psychotic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4186,
        6812
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2468",
          "EFO:0005407",
          "HP:0000709",
          "ICD9:298.8",
          "ICD9:298.9",
          "MEDGEN:19568",
          "NCIT:C78576",
          "SCTID:69322001",
          "UMLS:C0033975"
        ],
        "synonyms": [
          "mental or behavioral disorder",
          "mental or behavioural disorder",
          "psychosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An abnormal condition of the mind that involves a loss of contact with reality. People experiencing psychosis may exhibit personality changes and thought disorder. Depending on its severity, this may be accompanied by unusual or bizarre behavior, as well as difficulty with social interaction and impairment in carrying out daily life activities."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005485"
    }
  ],
  "children": [
    {
      "id": 3696,
      "label": "paranoid schizophrenia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1229",
          "ICD10CM:F20.0",
          "ICD9:295.3",
          "ICD9:295.30",
          "ICD9:295.31",
          "ICD9:295.32",
          "MEDGEN:20664",
          "MESH:D012563",
          "NCIT:C35006",
          "SCTID:31658008",
          "UMLS:C0036349"
        ],
        "synonyms": [
          "paranoid type schizophrenia",
          "paraphrenic schizophrenia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A subtype of schizophrenia characterized by prominent delusions (typically persecutory or grandiose) or hallucinations in the context of a relative preservation of cognitive functioning and affect."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001484"
    },
    {
      "id": 7088,
      "label": "treatment-refractory schizophrenia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004609",
          "MEDGEN:1786789",
          "UMLS:C3544321"
        ],
        "synonyms": [
          "TRS",
          "refractory schizophrenia",
          "treatment-refractory schizophrenia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Schizophrenia which does not respond to commonly used treatments."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005414"
    },
    {
      "id": 9710,
      "label": "schizophrenia 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070077",
          "MEDGEN:65084",
          "OMIM:181510",
          "UMLS:C0220702"
        ],
        "synonyms": [
          "SCZD1",
          "schizophrenia 1",
          "schizophrenia 1 with or without an affective disorder",
          "schizophrenia susceptibility locus, chromosome 5-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in an autosomal dominant mutation of SCZD1 on chromosome 5q23-q35."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008414"
    },
    {
      "id": 12030,
      "label": "schizophrenia 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070079",
          "MEDGEN:324936",
          "OMIM:600511",
          "UMLS:C1838069"
        ],
        "synonyms": [
          "SCZD3",
          "schizophrenia 3",
          "schizophrenia 3 with or without an affective disorder",
          "schizophrenia susceptibility locus, chromosome 6-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in an autosomal dominant mutation of SCZD3 on chromosome 6p23."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010897"
    },
    {
      "id": 12410,
      "label": "schizophrenia 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070081",
          "MEDGEN:350351",
          "OMIM:603175",
          "UMLS:C1864153"
        ],
        "synonyms": [
          "SCZD5",
          "schizophrenia 5",
          "schizophrenia 5 with or without an affective disorder",
          "schizophrenia susceptibility locus, chromosome 6Q-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in a mutation on chromosome 6q13-q26."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011294"
    },
    {
      "id": 12411,
      "label": "schizophrenia 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070083",
          "MEDGEN:350350",
          "OMIM:603176",
          "UMLS:C1864152"
        ],
        "synonyms": [
          "SCZD7",
          "schizophrenia 7",
          "schizophrenia 7 with or without an affective disorder",
          "schizophrenia susceptibility locus, chromosome 13Q-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in an autosomal dominant mutation of SCZD7 on chromosome 13q32."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011295"
    },
    {
      "id": 12414,
      "label": "schizophrenia 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070084",
          "MEDGEN:400456",
          "OMIM:603206",
          "UMLS:C1864124"
        ],
        "synonyms": [
          "SCZD8",
          "schizophrenia 8",
          "schizophrenia 8 with or without an affective disorder",
          "schizophrenia susceptibility locus, chromosome 18-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in an autosomal dominant mutation of SCZD8 on chromosome 18p."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011298"
    },
    {
      "id": 12423,
      "label": "schizophrenia 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070078",
          "MEDGEN:350323",
          "OMIM:603342",
          "UMLS:C1864010"
        ],
        "synonyms": [
          "SCZD2",
          "schizophrenia 2",
          "schizophrenia susceptibility locus, chromosome 11Q-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in an autosomal dominant mutation of SCZD2 on chromosome 11q14-q21."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011307"
    },
    {
      "id": 12649,
      "label": "schizophrenia 10",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070086",
          "MEDGEN:107776",
          "MESH:D012560",
          "OMIM:605419",
          "UMLS:C0543918"
        ],
        "synonyms": [
          "SCZD10",
          "schizophrenia 10",
          "catatonia, periodic",
          "schizophrenia susceptibility locus, chromosome 15Q15-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in an autosomal dominant mutation of SCZD10 on chromosome 15q15."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011552"
    },
    {
      "id": 13032,
      "label": "schizophrenia 11",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070087",
          "MEDGEN:334205",
          "OMIM:608078",
          "UMLS:C1842605"
        ],
        "synonyms": [
          "SCZD11",
          "schizophrenia 11",
          "schizophrenia type 11",
          "Sczd11",
          "schizophrenia susceptibility locus, chromosome 10Q-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in a mutation on chromosome 10q22.3."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011960"
    },
    {
      "id": 13122,
      "label": "schizophrenia 12",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070088",
          "MEDGEN:373838",
          "OMIM:608543",
          "UMLS:C1837893"
        ],
        "synonyms": [
          "SCZD12",
          "schizophrenia 12",
          "schizophrenia type 12",
          "Sczd12",
          "schizophrenia susceptibility locus, chromosome 1P-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in a mutation on chromosome 1p36.2."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012054"
    },
    {
      "id": 14528,
      "label": "schizophrenia 15",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070091",
          "MEDGEN:462730",
          "OMIM:613950",
          "UMLS:C3151380"
        ],
        "synonyms": [
          "SCZD15",
          "schizophrenia 15",
          "schizophrenia type 15",
          "schizophrenia 15 with or without an affective disorder",
          "schizophrenia susceptibility locus, chromosome 22Q13-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A schizophrenia that has material basis in a mutation of SHANK3 on chromosome 22q13.33."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013498"
    },
    {
      "id": 14536,
      "label": "schizophrenia 16",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3606,
        6817,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070092",
          "MEDGEN:462758",
          "OMIM:613959",
          "UMLS:C3151408"
        ],
        "synonyms": [
          "SCZD16",
          "schizophrenia 16",
          "schizophrenia type 16",
          "chromosome 7Q36.3 Duplication syndrome, 362-Kb",
          "schizophrenia susceptibility locus, chromosome 7Q36.3-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A schizophrenia that has material basis in a mutation on chromosome 7q36.3."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013506"
    },
    {
      "id": 14718,
      "label": "chromosome 2p16.3 deletion syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817,
        17309
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024940",
          "MEDGEN:814824",
          "OMIM:614332",
          "UMLS:C3808494"
        ],
        "synonyms": [
          "chromosome 2P16.3 deletion syndrome",
          "schizophrenia, susceptibility to, 17"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013696"
    },
    {
      "id": 19657,
      "label": "early-onset schizophrenia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019352",
          "MEDGEN:1800824",
          "Orphanet:96369",
          "UMLS:C1656427"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0019939"
    },
    {
      "id": 22640,
      "label": "schizophrenia 19",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080281",
          "MEDGEN:1613937",
          "OMIM:617629",
          "UMLS:C4539944"
        ],
        "synonyms": [
          "schizophrenia 19",
          "SCZD19",
          "schizophrenia 19 with or without an affective disorder",
          "schizophrenia 19, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0033312"
    },
    {
      "id": 24950,
      "label": "schizophrenia 17",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:482154",
          "OMIM:621407",
          "UMLS:C3280524"
        ],
        "synonyms": [
          "SCZD17"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0800358"
    },
    {
      "id": 25671,
      "label": "childhood-onset schizophrenia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6817
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004766",
          "MEDGEN:48576",
          "Orphanet:641496",
          "UMLS:C0036346"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957430"
    }
  ],
  "roots": [
    {
      "id": 7141,
      "label": "psychotic disorder"
    }
  ]
}