{
  "id": 6819,
  "label": "signet ring cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005092",
  "properties": {
    "xrefs": [
      "DOID:3493",
      "EFO:0000698",
      "ICDO:8490/3",
      "MEDGEN:61663",
      "MESH:D018279",
      "NCIT:C3774",
      "UMLS:C0206696"
    ],
    "synonyms": [
      "signet ring carcinoma NOS (morphologic abnormality)",
      "signet ring cell adenocarcinoma",
      "signet ring cell carcinoma",
      "signet ring cell carcinoma (morphologic abnormality)"
    ],
    "definition": "A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    }
  ],
  "children": [
    {
      "id": 4713,
      "label": "extrahepatic bile duct signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3494",
          "GARD:0023204",
          "MEDGEN:163667",
          "NCIT:C5776",
          "UMLS:C0861859"
        ],
        "synonyms": [
          "bile duct signet Ring cell carcinoma",
          "bile duct signet ring cell carcinoma",
          "extrahepatic bile duct signet Ring cell carcinoma",
          "signet Ring cell bile duct carcinoma",
          "signet Ring cell carcinoma of bile duct",
          "signet Ring cell carcinoma of the bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of signet ring malignant epithelial cells."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002664"
    },
    {
      "id": 4715,
      "label": "pancreatic signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6819,
        6905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3497",
          "GARD:0027610",
          "MEDGEN:233834",
          "NCIT:C5720",
          "UMLS:C1335317"
        ],
        "synonyms": [
          "pancreas signet ring cell carcinoma",
          "pancreatic signet Ring cell carcinoma",
          "pancreatic signet ring cell carcinoma",
          "signet Ring cell carcinoma of pancreas",
          "signet Ring cell carcinoma of the pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare pancreatic ductal adenocarcinoma with poor prognosis. It is characterized by the presence of malignant signet ring cells infiltrating the pancreatic parenchyma in an individual cell pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002666"
    },
    {
      "id": 4716,
      "label": "gallbladder signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6819,
        7768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3499",
          "GARD:0023206",
          "MEDGEN:232228",
          "NCIT:C5745",
          "UMLS:C1333758"
        ],
        "synonyms": [
          "gall bladder signet ring cell carcinoma",
          "gallbladder signet Ring cell carcinoma",
          "signet Ring cell carcinoma of gallbladder",
          "signet Ring cell carcinoma of the gallbladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the gallbladder. It is characterized by the presence of signet ring malignant epithelial cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002667"
    },
    {
      "id": 4719,
      "label": "signet ring cell breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6729,
        6819,
        7803
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3503",
          "MEDGEN:236816",
          "NCIT:C5175",
          "ONCOTREE:BRSRCC",
          "UMLS:C1335964"
        ],
        "synonyms": [
          "SRC breast carcinoma",
          "SRC carcinoma of breast",
          "SRC carcinoma of the breast",
          "breast signet ring cell carcinoma",
          "mammary signet Ring cell carcinoma",
          "primary SRC breast carcinoma",
          "primary SRC carcinoma of breast",
          "primary SRC carcinoma of the breast",
          "primary mammary signet Ring cell carcinoma",
          "primary signet Ring cell breast carcinoma",
          "primary signet Ring cell carcinoma of breast",
          "primary signet Ring cell carcinoma of the breast",
          "signet Ring cell breast carcinoma",
          "signet Ring cell carcinoma of breast",
          "signet Ring cell carcinoma of the breast",
          "breast carcinoma with signet ring",
          "breast signet ring cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "An invasive breast adenocarcinoma characterized by the presence of malignant epithelial cells with signet ring appearance."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002671"
    },
    {
      "id": 4720,
      "label": "acinar prostate adenocarcinoma, signet ring variant",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4572,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3504",
          "GARD:0027611",
          "MEDGEN:1835069",
          "NCIT:C5535",
          "UMLS:C5787291"
        ],
        "synonyms": [
          "acinar prostate adenocarcinoma, signet Ring variant",
          "prostate gland signet ring cell carcinoma",
          "signet Ring cell carcinoma of the prostate",
          "prostate signet ring cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A morphologic variant of acinar adenocarcinoma of the prostate gland characterized by the presence of signet ring malignant cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002672"
    },
    {
      "id": 5648,
      "label": "signet ring cell variant cervical mucinous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4778,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6101",
          "GARD:0023660",
          "MEDGEN:273126",
          "NCIT:C40205",
          "ONCOTREE:SCEMU",
          "UMLS:C1516424"
        ],
        "synonyms": [
          "cervical mucinous adenocarcinoma, signet Ring cell type",
          "cervical mucinous adenocarcinoma, signet Ring cell variant",
          "signet ring mucinous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare cervical mucinous adenocarcinoma characterized by the presence of signet ring cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003768"
    },
    {
      "id": 5753,
      "label": "bladder signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4786,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6481",
          "MEDGEN:231949",
          "NCIT:C6163",
          "UMLS:C1332563"
        ],
        "synonyms": [
          "bladder signet ring cell adenocarcinoma",
          "urinary bladder signet Ring adenocarcinoma",
          "urinary bladder signet ring cell carcinoma",
          "signet Ring cell adenocarcinoma of the bladder",
          "signet Ring cell adenocarcinoma of the urinary bladder",
          "signet Ring cell adenocarcinoma of urinary bladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A signet ring cell carcinoma that involves the urinary bladder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003891"
    },
    {
      "id": 6587,
      "label": "Krukenberg carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4787,
        6819,
        21603
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9597",
          "EFO:1000316",
          "GARD:0008627",
          "MEDGEN:9652",
          "MESH:D007725",
          "NCIT:C3153",
          "SCTID:359987004",
          "UMLS:C0022790"
        ],
        "synonyms": [
          "Krukenberg neoplasm",
          "Krukenberg tumor",
          "Krukenberg tumour",
          "Krukenberg’s tumor",
          "Krukenberg’s tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Metastatic signet-ring cell carcinoma to the ovary. The primary site is the gastrointestinal tract or breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004829"
    },
    {
      "id": 7824,
      "label": "lung signet ring cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6791,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080305",
          "EFO:1000338",
          "GARD:0024359",
          "ICD9:162.9",
          "MEDGEN:310950",
          "NCIT:C45514",
          "SCTID:707407001",
          "UMLS:C1708782"
        ],
        "synonyms": [
          "lung signet ring cell carcinoma",
          "signet ring lung adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A morphologic variant of lung adenocarcinoma characterized by the presence of signet ring cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006281"
    },
    {
      "id": 7928,
      "label": "signet ring cell gastric adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6770,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8025",
          "EFO:1000524",
          "GARD:0027754",
          "MEDGEN:234782",
          "NCIT:C5250",
          "ONCOTREE:SSRCC",
          "UMLS:C1335965"
        ],
        "synonyms": [
          "gastric signet Ring cell adenocarcinoma",
          "gastric signet ring cell adenocarcinoma",
          "signet Ring cell adenocarcinoma of stomach",
          "signet Ring cell adenocarcinoma of the stomach",
          "signet Ring cell stomach adenocarcinoma",
          "signet ring cell gastric adenocarcinoma",
          "signet ring cell carcinoma of the stomach"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006409"
    },
    {
      "id": 23338,
      "label": "colorectal signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6746,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:313040",
          "NCIT:C43586",
          "UMLS:C1707440"
        ],
        "synonyms": [
          "colorectal signet Ring cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive colorectal adenocarcinoma characterized by the presence of malignant glandular epithelial cells with prominent intracytoplasmic mucin resulting in the displacement of the nuclei. The malignant glandular cells with intracytoplasmic mucin constitute more than 50% of the malignant cellular infiltrate."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044336"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    }
  ]
}