{
  "id": 6824,
  "label": "squamous cell lung carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005097",
  "properties": {
    "xrefs": [
      "DOID:3907",
      "EFO:0000708",
      "ICD9:162.9",
      "MEDGEN:56202",
      "NCIT:C3493",
      "ONCOTREE:LUSC",
      "SCTID:254634000",
      "UMLS:C0149782"
    ],
    "synonyms": [
      "epidermoid cell carcinoma of lung",
      "epidermoid cell carcinoma of the lung",
      "epidermoid cell lung carcinoma",
      "lung squamous cell carcinoma",
      "squamous cell carcinoma of lung",
      "squamous cell carcinoma of the lung",
      "squamous cell lung cancer",
      "squamous cell lung carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 6862,
      "label": "lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        10167
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3905",
          "EFO:0001071",
          "MEDGEN:195765",
          "NCIT:C4878",
          "UMLS:C0684249",
          "icd11.foundation:947165291"
        ],
        "synonyms": [
          "cancer of lung",
          "cancer of the lung",
          "lung cancer",
          "lung cancer, NOS",
          "carcinoma of lung",
          "carcinoma of the lung",
          "lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the lung"
      },
      "child_count": 20,
      "reference_id": "MONDO:0005138"
    }
  ],
  "children": [
    {
      "id": 5766,
      "label": "lung occult squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6824
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6510",
          "MEDGEN:235400",
          "NCIT:C6686",
          "UMLS:C1335100"
        ],
        "synonyms": [
          "occult squamous cell carcinoma of the lung",
          "occult squamous cell lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A squamous cell lung carcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003904"
    },
    {
      "id": 23667,
      "label": "non-small cell squamous lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6824,
        6944
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080521",
          "MEDGEN:1383559",
          "NCIT:C133254",
          "SCTID:723301009",
          "UMLS:C4509816"
        ],
        "synonyms": [
          "non-small cell squamous lung cancer",
          "non-small cell squamous lung carcinoma",
          "squamous non-small cell lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the lung. It is characterized by the presence of large malignant cells. It includes the clear cell and papillary variants of squamous cell carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0056806"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 6862,
      "label": "lung carcinoma"
    }
  ]
}