{
  "id": 6830,
  "label": "well-differentiated liposarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005103",
  "properties": {
    "xrefs": [
      "EFO:0000736",
      "GARD:0019721",
      "ICDO:8851/3",
      "MEDGEN:237164",
      "NCIT:C4250",
      "ONCOTREE:WDLS",
      "Orphanet:99971",
      "UMLS:C1370889"
    ],
    "synonyms": [
      "atypical lipomatous tumor",
      "atypical lipomatous tumour",
      "ALT",
      "WDLS",
      "atypical lipoma",
      "well differentiated liposarcoma",
      "well differentiated liposarcoma of deep soft tissue",
      "well-differentiated liposarcoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A locally aggressive malignant neoplasm composed of mature adipocytes showing cell size variation and nuclear atypia. It is often associated with the presence of hyperchromatic multinucleated stromal cells, and varying numbers of lipoblasts. There are three histologic subtypes, sclerosing, inflammatory, and spindle cell liposarcoma. These tumors do not usually metastasize unless they undergo dedifferentiation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6790,
      "label": "liposarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4839,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3382",
          "EFO:0000569",
          "GARD:0006913",
          "ICD9:171.9",
          "ICDO:8850/3",
          "MEDGEN:44177",
          "MESH:D008080",
          "MedDRA:10024627",
          "NANDO:2200065",
          "NCIT:C3194",
          "NORD:1925",
          "ONCOTREE:LIPO",
          "Orphanet:69078",
          "SCTID:254829001",
          "UMLS:C0023827"
        ],
        "synonyms": [
          "lip sarcoma",
          "liposarcoma",
          "liposarcoma, malignant",
          "sarcoma of lip"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential is higher in less differentiated tumors."
      },
      "child_count": 38,
      "reference_id": "MONDO:0005060"
    }
  ],
  "children": [
    {
      "id": 5490,
      "label": "sclerosing liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6830
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5704",
          "GARD:0023579",
          "ICD9:171.9",
          "MEDGEN:137767",
          "NCIT:C6507",
          "SCTID:404068003",
          "UMLS:C0334469"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A morphologic variant of well differentiated liposarcoma occurring most often in the retroperitoneum and paratesticular area. It is characterized by the presence of bizarre hyperchromatic stromal cells and rare multivacuolated lipoblasts within a fibrous stroma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003595"
    },
    {
      "id": 5491,
      "label": "spindle cell liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4933,
        6830
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5705",
          "GARD:0023580",
          "ICD9:171.9",
          "MEDGEN:266156",
          "NCIT:C27489",
          "SCTID:404073009",
          "UMLS:C1275275"
        ],
        "synonyms": [
          "spindle cell liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A morphologic variant of well differentiated liposarcoma characterized by the presence of bland spindle cells and lipoblasts within a myxoid or fibrous stroma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003596"
    },
    {
      "id": 6312,
      "label": "inflammatory liposarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6830,
        7671
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8233",
          "GARD:0024042",
          "MEDGEN:234588",
          "NCIT:C6508",
          "UMLS:C1370890"
        ],
        "synonyms": [
          "inflammatory liposarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A rare morphologic variant of well differentiated liposarcoma occurring most often in the retroperitoneum. It is characterized by the presence of a predominant inflammatory infiltrate composed of lymphoplasmacytic aggregates."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004510"
    }
  ],
  "roots": [
    {
      "id": 6790,
      "label": "liposarcoma"
    }
  ]
}