{
  "id": 6838,
  "label": "malignant pleural mesothelioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005112",
  "properties": {
    "xrefs": [
      "DOID:7474",
      "EFO:0000770",
      "GARD:0024150",
      "MEDGEN:208810",
      "NCIT:C7376",
      "SCTID:254645002",
      "UMLS:C0812413"
    ],
    "synonyms": [
      "pleura mesothelioma",
      "malignant mesothelioma of pleura",
      "malignant mesothelioma of the pleura",
      "malignant pleural mesothelioma",
      "pleural diffuse malignant mesothelioma",
      "pleural malignant mesothelioma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A malignant neoplasm that arises from mesothelial cells in the pleura and shows a diffuse growth pattern. It arises on the parietal and sometimes visceral pleura as multiple small nodules that later become confluent and invade the chest wall adipose tissue and muscle. Asbestos exposure is the main cause for the development of pleural malignant mesothelioma. It usually affects patients over sixty years of age. The latency period is long. Patients usually present with pleural effusion, dyspnea and chest wall pain. Additional signs and symptoms include chills, sweating, weight loss, and weakness. Morphologic variants include epithelioid, desmoplastic, sarcomatoid, and biphasic mesothelioma. The clinical course is usually aggressive."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5249,
      "label": "pleural mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6794,
        20306
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5157",
          "EFO:1000485",
          "HP:0100002",
          "ICD10CM:C45.0",
          "MEDGEN:237179",
          "NCIT:C9351",
          "ONCOTREE:PLMESO",
          "SCTID:109372009",
          "UMLS:C1377913"
        ],
        "synonyms": [
          "mesothelioma of pleura",
          "mesothelioma of the pleura",
          "pleura mesothelioma",
          "pleural mesothelioma",
          "pleural mesothelioma (disease)",
          "benign pleural mesothelioma",
          "pleural mesothelioma (disease), benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003308"
    },
    {
      "id": 7834,
      "label": "malignant mesothelioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6794
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1790",
          "EFO:1000355",
          "GARD:0007026",
          "HP:0100001",
          "ICD9:199.1",
          "ICDO:9050/3",
          "MEDGEN:91062",
          "MESH:C562839",
          "MedDRA:10027406",
          "NCIT:C4456",
          "OMIM:156240",
          "Orphanet:50251",
          "SCTID:109378008",
          "UMLS:C0345967",
          "icd11.foundation:369414280"
        ],
        "synonyms": [
          "malignant mesothelial tumor",
          "malignant mesothelial tumour",
          "malignant mesothelioma",
          "malignant mesothelioma (disease)",
          "malignant neoplasm of mesothelium",
          "malignant neoplasm of the mesothelium",
          "malignant tumor of mesothelium",
          "malignant tumor of the mesothelium",
          "malignant tumour of mesothelium",
          "malignant tumour of the mesothelium",
          "mesothelioma, malignant",
          "mesothelioma, somatic",
          "advanced malignant mesothelioma",
          "asbestos-related malignant mesothelioma",
          "diffuse malignant mesothelioma",
          "malignant mesothelial neoplasm",
          "MESOM"
        ],
        "definition": "A malignant neoplasm of the pleura or peritoneum, arising from mesothelial cells. It is associated with exposure to asbestos."
      },
      "child_count": 22,
      "reference_id": "MONDO:0006292"
    },
    {
      "id": 7835,
      "label": "pleural cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2875,
        5215,
        20306
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5158",
          "EFO:1000362",
          "ICD10CM:C38.4",
          "ICD9:163",
          "ICD9:163.8",
          "ICD9:163.9",
          "MEDGEN:56307",
          "NCIT:C3547",
          "SCTID:363433009",
          "UMLS:C0153494"
        ],
        "synonyms": [
          "neoplasm of pleura",
          "pleural tumor",
          "pleural tumour",
          "cancer of pleura",
          "cancer of the pleura",
          "malignant neoplasm of pleura",
          "malignant neoplasm of the pleura",
          "malignant pleura neoplasm",
          "malignant pleural neoplasm",
          "malignant pleural tumor",
          "malignant pleural tumour",
          "malignant tumor of pleura",
          "malignant tumor of the pleura",
          "malignant tumour of pleura",
          "malignant tumour of the pleura",
          "pleura cancer",
          "pleural cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm affecting the pleura. A representative example of primary malignant pleural neoplasm is the malignant pleural mesothelioma. A representative example of metastatic malignant neoplasm to the pleura is metastatic carcinoma that has spread to the pleura from another anatomic site."
      },
      "child_count": 12,
      "reference_id": "MONDO:0006294"
    }
  ],
  "children": [
    {
      "id": 7900,
      "label": "pleural epithelioid mesothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6838,
        7243
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000484",
          "GARD:0024387",
          "MEDGEN:318031",
          "NCIT:C45662",
          "UMLS:C1709574"
        ],
        "synonyms": [
          "malignant epithelioid mesothelioma of pleura",
          "pleura malignant epithelioid mesothelioma",
          "pleural epithelioid mesothelioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Malignant mesothelioma that arises from the pleura and is characterized by the presence of cells with epithelioid morphology. The epithelioid cells usually have eosinophilic cytoplasm, bland nuclei, and form tubulopapillary, microglandular, or sheet-like patterns."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006378"
    },
    {
      "id": 7901,
      "label": "pleural sarcomatoid mesothelioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6838,
        7926
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000486",
          "GARD:0024388",
          "MEDGEN:354059",
          "NCIT:C45663",
          "UMLS:C1709578"
        ],
        "synonyms": [
          "pleura sarcomatoid mesothelioma",
          "pleural sarcomatoid mesothelioma",
          "sarcomatoid mesothelioma of pleura"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Malignant mesothelioma that arises from the pleura and is characterized by the presence of spindle-shaped cells forming fascicles, or that are distributed haphazardly resembling a sarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006380"
    }
  ],
  "roots": [
    {
      "id": 5249,
      "label": "pleural mesothelioma"
    },
    {
      "id": 7834,
      "label": "malignant mesothelioma"
    },
    {
      "id": 7835,
      "label": "pleural cancer"
    }
  ]
}