{
  "id": 6855,
  "label": "cervical carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005131",
  "properties": {
    "xrefs": [
      "DOID:2893",
      "EFO:0001061",
      "MEDGEN:86222",
      "NCIT:C9039",
      "SCTID:285432005",
      "UMLS:C0302592",
      "icd11.foundation:1743710977"
    ],
    "synonyms": [
      "cancer of cervix",
      "cancer of the cervix",
      "cancer of the uterine cervix",
      "cancer of uterine cervix",
      "cervical cancer",
      "cervical cancer, NOS",
      "cervix cancer",
      "uterine cervix cancer",
      "carcinoma of cervix",
      "carcinoma of cervix uteri",
      "carcinoma of the cervix",
      "carcinoma of the cervix uteri",
      "carcinoma of the uterine cervix",
      "carcinoma of uterine cervix",
      "cervical carcinoma",
      "cervix carcinoma",
      "cervix uteri carcinoma",
      "uterine cervix carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4978,
      "label": "cervical cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4754,
        20440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4362",
          "ICD10CM:C53",
          "ICD9:180",
          "ICD9:180.8",
          "ICD9:180.9",
          "MEDGEN:890252",
          "NCIT:C9311",
          "OMIM:603956",
          "SCTID:363354003",
          "UMLS:C4048328",
          "icd11.foundation:1256072522"
        ],
        "synonyms": [
          "cervical neoplasm",
          "tumor of the cervix uteri",
          "tumour of the cervix uteri",
          "uterine cervical neoplasm",
          "cancer of uterine cervix",
          "cervical cancer, somatic",
          "malignant cervical neoplasm",
          "malignant cervical tumor",
          "malignant cervical tumour",
          "malignant cervix neoplasm",
          "malignant cervix tumor",
          "malignant cervix tumour",
          "malignant cervix uteri neoplasm",
          "malignant cervix uteri tumor",
          "malignant cervix uteri tumour",
          "malignant neoplasm of cervix",
          "malignant neoplasm of cervix uteri",
          "malignant neoplasm of the cervix",
          "malignant neoplasm of the cervix uteri",
          "malignant neoplasm of the uterine cervix",
          "malignant neoplasm of uterine cervix",
          "malignant tumor of cervix",
          "malignant tumor of cervix uteri",
          "malignant tumor of the cervix",
          "malignant tumor of the cervix uteri",
          "malignant tumor of the uterine cervix",
          "malignant tumor of uterine cervix",
          "malignant tumour of cervix",
          "malignant tumour of cervix uteri",
          "malignant tumour of the cervix",
          "malignant tumour of the cervix uteri",
          "malignant tumour of the uterine cervix",
          "malignant tumour of uterine cervix",
          "malignant uterine cervix neoplasm",
          "malignant uterine cervix tumor",
          "malignant uterine cervix tumour",
          "uterine cervix cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the cervix."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002974"
    },
    {
      "id": 6929,
      "label": "uterine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4754,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002919",
          "MEDGEN:755620",
          "SCTID:446022000",
          "UMLS:C2960452"
        ],
        "synonyms": [
          "carcinoma of uterus",
          "uterus carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma involving a uterus."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005213"
    }
  ],
  "children": [
    {
      "id": 4537,
      "label": "exocervical carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2892",
          "MEDGEN:226967",
          "NCIT:C7453",
          "SCTID:372100004",
          "UMLS:C1299238"
        ],
        "synonyms": [
          "carcinoma of ectocervix",
          "carcinoma of exocervix",
          "carcinoma of the exocervix",
          "ectocervix carcinoma",
          "exocervical cancer",
          "exocervical carcinoma",
          "exocervix carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the squamous epithelium of the exocervix."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002455"
    },
    {
      "id": 6079,
      "label": "endocervical carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6855,
        20491
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7519",
          "MEDGEN:226966",
          "NCIT:C28327",
          "SCTID:372098004",
          "UMLS:C1299237"
        ],
        "synonyms": [
          "carcinoma of endocervix",
          "endocervical cancer",
          "endocervix carcinoma",
          "endocervical adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the endocervix."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004259"
    },
    {
      "id": 6877,
      "label": "cervical adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3702",
          "EFO:0001416",
          "GARD:0020488",
          "MEDGEN:79024",
          "NCIT:C4029",
          "ONCOTREE:CEAD",
          "Orphanet:213772",
          "SCTID:254887002",
          "UMLS:C0279672",
          "icd11.foundation:261293318"
        ],
        "synonyms": [
          "adenocarcinoma - cervix",
          "adenocarcinoma of cervix",
          "adenocarcinoma of cervix uteri",
          "adenocarcinoma of the cervix",
          "adenocarcinoma of the cervix uteri",
          "adenocarcinoma of the uterine cervix",
          "adenocarcinoma of uterine cervix",
          "cervical adenocarcinoma",
          "cervix adenocarcinoma",
          "cervix uteri adenocarcinoma",
          "uterine cervix adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the cervical epithelium. It accounts for approximately 15% of invasive cervical carcinomas. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors. Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement. Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type."
      },
      "child_count": 20,
      "reference_id": "MONDO:0005153"
    },
    {
      "id": 7696,
      "label": "cervical adenoid basal carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4956,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6428",
          "EFO:1000160",
          "GARD:0020499",
          "MEDGEN:275704",
          "NCIT:C40213",
          "ONCOTREE:CABC",
          "Orphanet:213828",
          "UMLS:C1516403"
        ],
        "synonyms": [
          "adenoid basal carcinoma of the cervix uteri",
          "cervical adenoid basal cancer",
          "cervical adenoid basal carcinoma",
          "skin adenoid basal cell carcinoma of uterine cervix",
          "uterine cervix skin adenoid basal cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare low grade carcinoma that arises from the cervix. It is characterized by the presence of nests of basaloid cells with focal glandular formations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006132"
    },
    {
      "id": 7701,
      "label": "cervical large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6787,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6659",
          "EFO:1000167",
          "GARD:0024306",
          "MEDGEN:275711",
          "NCIT:C40214",
          "ONCOTREE:CENE",
          "UMLS:C1516417"
        ],
        "synonyms": [
          "cervical large cell neuroendocrine carcinoma",
          "cervical neuroendocrine tumor",
          "cervical neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, aggressive neuroendocrine carcinoma that arises from the cervix and is characterized by the presence of malignant cells with abundant cytoplasm, large nuclei, and prominent nucleoli."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006138"
    },
    {
      "id": 7705,
      "label": "cervical small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6740",
          "EFO:1000171",
          "GARD:0024309",
          "MEDGEN:79025",
          "NCIT:C7982",
          "ONCOTREE:SCCE",
          "UMLS:C0279674"
        ],
        "synonyms": [
          "Cervical small cell cancer",
          "cervical small cell carcinoma",
          "cervix small cell carcinoma",
          "cervix uteri small cell carcinoma",
          "small cell carcinoma of cervix",
          "small cell carcinoma of cervix uteri",
          "small cell carcinoma of the cervix",
          "small cell carcinoma of the cervix uteri",
          "small cell carcinoma of the uterine cervix",
          "small cell carcinoma of uterine cervix",
          "uterine cervix small cell carcinoma",
          "SCCE"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A small cell carcinoma arising from the cervix."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006142"
    },
    {
      "id": 7706,
      "label": "cervical squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3744",
          "EFO:1000172",
          "GARD:0020487",
          "MEDGEN:124644",
          "NCIT:C4028",
          "ONCOTREE:CESC",
          "Orphanet:213767",
          "SCTID:254886006",
          "UMLS:C0279671",
          "icd11.foundation:1544785014"
        ],
        "synonyms": [
          "cervical squamous cell cancer",
          "cervical squamous cell carcinoma",
          "cervix squamous cell carcinoma",
          "cervix uteri squamous cell carcinoma",
          "squamous cell carcinoma of cervix",
          "squamous cell carcinoma of cervix uteri",
          "squamous cell carcinoma of the cervix",
          "squamous cell carcinoma of the cervix uteri",
          "squamous cell carcinoma of the uterine cervix",
          "squamous cell carcinoma of uterine cervix",
          "squamous cervical cancer",
          "uterine cervix squamous cell carcinoma",
          "CESC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis."
      },
      "child_count": 14,
      "reference_id": "MONDO:0006143"
    },
    {
      "id": 16844,
      "label": "papillary carcinoma of the cervix uteri",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6855,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020497",
          "Orphanet:213817"
        ],
        "synonyms": [
          "cervical papillary carcinoma",
          "uterine cervix papillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A papillary carcinoma that involves the uterine cervix."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016285"
    },
    {
      "id": 23061,
      "label": "uterine cervix carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6489,
        6855
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8991",
          "ICD9:233.1",
          "MEDGEN:163094",
          "MESH:D018290",
          "NCIT:C4000",
          "SCTID:254889004",
          "UMLS:C0851140"
        ],
        "synonyms": [
          "CIN 3 aJCC v6",
          "CIN grade 3 aJCC v6",
          "FIGO stage 0 carcinoma of cervix",
          "FIGO stage 0 carcinoma of cervix uteri",
          "FIGO stage 0 carcinoma of the cervix",
          "FIGO stage 0 carcinoma of the cervix uteri",
          "FIGO stage 0 carcinoma of the uterine cervix",
          "FIGO stage 0 carcinoma of uterine cervix",
          "FIGO stage 0 cervical carcinoma",
          "FIGO stage 0 cervix carcinoma",
          "FIGO stage 0 cervix uteri carcinoma",
          "FIGO stage 0 uterine cervix carcinoma",
          "carcinoma in situ of cervix aJCC v6",
          "carcinoma in situ of cervix uteri aJCC v6",
          "carcinoma in situ of the cervix aJCC v6",
          "carcinoma in situ of the cervix uteri aJCC v6",
          "carcinoma in situ of the uterine cervix aJCC v6",
          "carcinoma in situ of uterine cervix",
          "carcinoma in situ of uterine cervix aJCC v6",
          "cervical Severe dysplasia aJCC v6",
          "cervical cancer stage 0 aJCC v6",
          "cervical carcinoma in situ aJCC v6",
          "cervical intraepithelial neoplasia grade 3 aJCC v6",
          "cervix Severe dysplasia aJCC v6",
          "cervix carcinoma in situ aJCC v6",
          "cervix intraepithelial neoplasia grade 3 aJCC v6",
          "cervix uteri Severe dysplasia aJCC v6",
          "cervix uteri carcinoma in situ aJCC v6",
          "cervix uteri intraepithelial neoplasia grade 3 aJCC v6",
          "grade 3 cervical intraepithelial neoplasia aJCC v6",
          "intraepithelial neoplasia of cervix grade 3 aJCC v6",
          "intraepithelial neoplasia of cervix uteri grade 3 aJCC v6",
          "intraepithelial neoplasia of the cervix grade 3 aJCC v6",
          "intraepithelial neoplasia of the cervix uteri grade 3 aJCC v6",
          "intraepithelial neoplasia of the uterine cervix grade 3 aJCC v6",
          "intraepithelial neoplasia of uterine cervix grade 3 aJCC v6",
          "severe cervical dysplasia aJCC v6",
          "severe dysplasia of cervix aJCC v6",
          "severe dysplasia of cervix uteri aJCC v6",
          "severe dysplasia of the cervix aJCC v6",
          "severe dysplasia of the cervix uteri aJCC v6",
          "severe dysplasia of the uterine cervix aJCC v6",
          "severe dysplasia of uterine cervix aJCC v6",
          "stage 0 cervical cancer",
          "stage 0 cervical cancer aJCC v6",
          "stage 0 uterine cervix carcinoma",
          "uterine cervix Severe dysplasia aJCC v6",
          "uterine cervix carcinoma in situ aJCC v6",
          "uterine cervix intraepithelial neoplasia grade 3 aJCC v6",
          "cervix uteri carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003"
      },
      "child_count": 0,
      "reference_id": "MONDO:0042487"
    }
  ],
  "roots": [
    {
      "id": 4978,
      "label": "cervical cancer"
    },
    {
      "id": 6929,
      "label": "uterine carcinoma"
    }
  ]
}