{
  "id": 6862,
  "label": "lung carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005138",
  "properties": {
    "xrefs": [
      "DOID:3905",
      "EFO:0001071",
      "MEDGEN:195765",
      "NCIT:C4878",
      "UMLS:C0684249",
      "icd11.foundation:947165291"
    ],
    "synonyms": [
      "cancer of lung",
      "cancer of the lung",
      "lung cancer",
      "lung cancer, NOS",
      "carcinoma of lung",
      "carcinoma of the lung",
      "lung carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the lung"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    },
    {
      "id": 10167,
      "label": "lung cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2875,
        5215,
        20356
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1324",
          "ICD9:162.3",
          "ICD9:162.4",
          "ICD9:162.5",
          "ICD9:162.8",
          "ICD9:162.9",
          "MEDGEN:66885",
          "NCIT:C7377",
          "OMIM:211980",
          "SCTID:363358000",
          "UMLS:C0242379"
        ],
        "synonyms": [
          "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
          "adenocarcinoma of lung, somatic",
          "cancer of lung",
          "lung cancer",
          "lung cancer, protection against, autosomal dominant, somatic mutation",
          "lung cancer, resistance to, autosomal dominant, somatic mutation",
          "lung cancer, somatic",
          "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
          "malignant lung neoplasm",
          "malignant lung tumor",
          "malignant lung tumour",
          "malignant neoplasm of lung",
          "malignant neoplasm of the lung",
          "malignant tumor of lung",
          "malignant tumor of the lung",
          "malignant tumour of lung",
          "malignant tumour of the lung",
          "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
          "nonsmall cell lung cancer, somatic",
          "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
          "Nonsmall cell lung cancer",
          "alveolar cell carcinoma",
          "lung cancer, protection against"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the lung."
      },
      "child_count": 21,
      "reference_id": "MONDO:0008903"
    }
  ],
  "children": [
    {
      "id": 4832,
      "label": "bronchogenic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3865,
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2017-6052",
          "DOID:3904",
          "EFO:1001942",
          "ICD9:162.9",
          "MEDGEN:2872",
          "MESH:D002283",
          "NCIT:C35875",
          "SCTID:254622008",
          "UMLS:C0007121"
        ],
        "synonyms": [
          "bronchial carcinoma",
          "bronchiogenic carcinoma",
          "bronchogenic carcinoma",
          "bronchogenic lung cancer",
          "bronchogenic lung carcinoma",
          "bronchus carcinoma",
          "carcinoma of bronchus",
          "carcinoma, bronchial, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lung carcinoma arising from the bronchial epithelium."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002806"
    },
    {
      "id": 6112,
      "label": "asbestos-related lung carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7596",
          "MEDGEN:231080",
          "NCIT:C27925",
          "UMLS:C1332337"
        ],
        "synonyms": [
          "asbestos-related lung cancer",
          "asbestos-related lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma arising in the lung due to exposure to asbestos."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004295"
    },
    {
      "id": 6301,
      "label": "lung hilum carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6148,
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8207",
          "MEDGEN:235266",
          "NCIT:C7454",
          "UMLS:C1334445"
        ],
        "synonyms": [
          "lung hilum cancer",
          "carcinoma of lung hilus",
          "hilar lung carcinoma",
          "lung hilum carcinoma",
          "lung hilus carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lung carcinoma arising from the hilum of the lung."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004499"
    },
    {
      "id": 6444,
      "label": "lung carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8800",
          "ICD9:231.2",
          "MEDGEN:146894",
          "NCIT:C27467",
          "SCTID:92649001",
          "UMLS:C0685053"
        ],
        "synonyms": [
          "bronchial carcinoma in situ",
          "carcinoma in situ of lung",
          "lung in situ carcinoma",
          "stage 0 lung cancer",
          "stage 0 lung cancer aJCC v6",
          "stage 0 lung cancer aJCC v6 and v7",
          "stage 0 lung cancer aJCC v7",
          "stage 0 lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma in situ involving a lung."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004660"
    },
    {
      "id": 6824,
      "label": "squamous cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3907",
          "EFO:0000708",
          "ICD9:162.9",
          "MEDGEN:56202",
          "NCIT:C3493",
          "ONCOTREE:LUSC",
          "SCTID:254634000",
          "UMLS:C0149782"
        ],
        "synonyms": [
          "epidermoid cell carcinoma of lung",
          "epidermoid cell carcinoma of the lung",
          "epidermoid cell lung carcinoma",
          "lung squamous cell carcinoma",
          "squamous cell carcinoma of lung",
          "squamous cell carcinoma of the lung",
          "squamous cell lung cancer",
          "squamous cell lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A carcinoma arising from squamous bronchial epithelial cells. It may be keratinizing or non-keratinizing. Keratinizing squamous cell carcinoma is characterized by the presence of keratinization, pearl formation, and/or intercellular bridges. Non-keratinizing squamous cell carcinoma is characterized by the absence of keratinization, pearl formation, and intercellular bridges. Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005097"
    },
    {
      "id": 6944,
      "label": "non-small cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3908",
          "EFO:0003060",
          "HP:0030358",
          "MEDGEN:40104",
          "MESH:D002289",
          "NCIT:C2926",
          "ONCOTREE:NSCLC",
          "Orphanet:488201",
          "SCTID:254637007",
          "UMLS:C0007131"
        ],
        "synonyms": [
          "NSCLC",
          "NSCLC - non-small cell lung cancer",
          "non-small cell cancer of lung",
          "non-small cell cancer of the lung",
          "non-small cell carcinoma of lung",
          "non-small cell carcinoma of the lung",
          "non-small cell lung cancer",
          "non-small cell lung carcinoma",
          "non-small cell lung carcinoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005233"
    },
    {
      "id": 7728,
      "label": "combined lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        6862,
        7117,
        7464
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000200",
          "GARD:0024316",
          "MEDGEN:234166",
          "NCIT:C7591",
          "UMLS:C1333123"
        ],
        "synonyms": [
          "combined carcinoma of lung",
          "combined carcinoma of the lung",
          "combined lung cancer",
          "combined lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A lung carcinoma characterized by the presence of large or small neuroendocrine carcinoma cells in combination with malignant glandular or squamous epithelial cells."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006167"
    },
    {
      "id": 7819,
      "label": "lung inflammatory myofibroblastic tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6862,
        16551
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000333",
          "GARD:0024358",
          "ICDO:8827/1",
          "MEDGEN:273512",
          "NCIT:C39740",
          "ONCOTREE:IMTL",
          "UMLS:C1518038"
        ],
        "synonyms": [
          "lung inflammatory myofibroblastic tumor",
          "inflammatory myofibroblastic lung tumor",
          "inflammatory myofibroblastic lung tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An intermediate fibroblastic neoplasm arising from the lung. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006276"
    },
    {
      "id": 9726,
      "label": "small cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2894,
        6862,
        7117
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5409",
          "DOID:5411",
          "EFO:0000702",
          "GARD:0009344",
          "ICD9:162.9",
          "MEDGEN:57450",
          "MESH:D055752",
          "NCIT:C4917",
          "OMIM:182280",
          "ONCOTREE:SCLC",
          "Orphanet:70573",
          "SCTID:254632001",
          "UMLS:C0149925",
          "icd11.foundation:1800431439"
        ],
        "synonyms": [
          "SCLC",
          "oat cell carcinoma",
          "oat cell carcinoma (morphologic abnormality)",
          "poorly differentiated endocrine neoplasm",
          "Small cell lung cancer",
          "lung oat cell carcinoma",
          "lung small cell carcinoma",
          "lung small cell neuroendocrine carcinoma",
          "oat cell carcinoma of lung",
          "oat cell carcinoma of the lung",
          "oat cell lung carcinoma",
          "small cell cancer of the lung, somatic",
          "small cell carcinoma of lung",
          "small cell carcinoma of the lung",
          "small cell lung cancer",
          "small cell neuroendocrine carcinoma of lung",
          "small cell neuroendocrine carcinoma of the lung",
          "small-cell cancer of lung",
          "SCLC1",
          "small cell cancer of the lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized byrapid growth, and early metastasis. SCLC usually manifests as a large hilar mass with bulky mediastinal lymphadenopathy presenting clinically with chest pain, persistent cough, dyspnea, wheezing, hoarseness, hemoptysis, loss of appetite, weight loss, and neurological and endocrine paraneoplastic syndromes. SCLC is primarily reported in elderly people with a history of long-term tobacco exposure."
      },
      "child_count": 6,
      "reference_id": "MONDO:0008433"
    },
    {
      "id": 20105,
      "label": "lung epithelial-myoepithelial carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5321,
        6862
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027874",
          "MEDGEN:353868",
          "NCIT:C45545",
          "UMLS:C1708770"
        ],
        "synonyms": [
          "lung epithelial-myoepithelial cancer",
          "lung epithelial-myoepithelial carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lung carcinoma arising within the bronchi or bronchial tubes. It is characterized by the presence of myoepithelial cells, spindle cells, clear cells, and duct-forming epithelial cells. Surgical resection may be curative."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020697"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    },
    {
      "id": 10167,
      "label": "lung cancer"
    }
  ]
}