{
  "id": 6864,
  "label": "ovarian carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005140",
  "properties": {
    "xrefs": [
      "DOID:4001",
      "EFO:0001075",
      "GARD:0024154",
      "MEDGEN:1648335",
      "NCIT:C4908",
      "UMLS:C4721610"
    ],
    "synonyms": [
      "ovarian cancer",
      "ovarian epithelial cancer",
      "carcinoma of ovary",
      "carcinoma of the ovary",
      "epithelial ovarian cancer",
      "ovarian carcinoma",
      "ovary carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 18447,
      "label": "malignant epithelial tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4347,
        6734,
        9481
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2151",
          "GARD:0009362",
          "MEDGEN:577291",
          "MESH:C538090",
          "NCIT:C40026",
          "Orphanet:398934",
          "SCTID:254849005",
          "UMLS:C0346161"
        ],
        "synonyms": [
          "epithelial cancer of ovary",
          "malignant ovarian epithelial tumor",
          "malignant ovarian epithelial tumour",
          "malignant ovarian surface epithelial-stromal neoplasm",
          "malignant ovarian surface epithelial-stromal tumor",
          "malignant ovarian surface epithelial-stromal tumour",
          "ovarian epithelial cancer",
          "ovarian epithelial tumor, malignant",
          "ovarian malignant epithelial tumor",
          "ovarian malignant epithelial tumour",
          "ovarian stromal cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An invasive malignant tumor that originates from the surface epithelium of the ovary. It is composed of malignant epithelial cells and stroma. Representative examples include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, clear cell adenocarcinoma, and malignant Brenner tumor."
      },
      "child_count": 18,
      "reference_id": "MONDO:0018364"
    }
  ],
  "children": [
    {
      "id": 4787,
      "label": "ovarian adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6864
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3713",
          "EFO:0006460",
          "GARD:0020466",
          "MEDGEN:181757",
          "MedDRA:10051938",
          "NCIT:C7700",
          "Orphanet:213504",
          "UMLS:C0948216"
        ],
        "synonyms": [
          "adenocarcinoma of ovary",
          "adenocarcinoma of the ovary",
          "ovarian adenocarcinoma",
          "ovary adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the ovary. It is the most common type of ovarian carcinoma. It includes the serous adenocarcinoma, mucinous adenocarcinoma, clear cell adenocarcinoma, and endometrioid adenocarcinoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002752"
    },
    {
      "id": 5039,
      "label": "ovarian large-cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4561,
        6787,
        6864
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4555",
          "GARD:0023345",
          "MEDGEN:233809",
          "NCIT:C5238",
          "UMLS:C1335174"
        ],
        "synonyms": [
          "large cell neuroendocrine carcinoma of ovary",
          "large cell neuroendocrine carcinoma of the ovary",
          "large-cell neuroendocrine carcinoma of ovary",
          "large-cell neuroendocrine carcinoma of the ovary",
          "non-small-cell type neuroendocrine carcinoma of ovary",
          "non-small-cell type neuroendocrine carcinoma of the ovary",
          "ovarian large cell NEC",
          "ovarian large cell neuroendocrine carcinoma",
          "ovarian non-small-cell type neuroendocrine carcinoma",
          "ovary large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the ovary and is characterized by the presence of large malignant cells exhibiting neuroendocrine differentiation. The prognosis is poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003049"
    },
    {
      "id": 5410,
      "label": "ovarian squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5411,
        6823,
        6864
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5531",
          "EFO:1000432",
          "GARD:0023529",
          "MEDGEN:384474",
          "NCIT:C40093",
          "UMLS:C2019443"
        ],
        "synonyms": [
          "ovarian squamous cell cancer",
          "ovarian squamous cell carcinoma",
          "ovary squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually high grade squamous cell carcinoma that arises from the ovary and is not associated with a germ cell tumor. The prognosis is poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003494"
    },
    {
      "id": 5671,
      "label": "ovarian carcinosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4934,
        5685,
        6864
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6170",
          "EFO:1000412",
          "GARD:0007296",
          "MEDGEN:140705",
          "NCIT:C9192",
          "ONCOTREE:OCS",
          "Orphanet:213512",
          "SCTID:702368000",
          "UMLS:C0392998"
        ],
        "synonyms": [
          "MMMT of the ovary",
          "carcinosarcoma of ovary",
          "carcinosarcoma of the ovary",
          "malignant mixed mesodermal Mullerian neoplasm of ovary",
          "malignant mixed mesodermal Mullerian neoplasm of the ovary",
          "malignant mixed mesodermal Mullerian tumor of ovary",
          "malignant mixed mesodermal Mullerian tumor of the ovary",
          "malignant mixed mesodermal Mullerian tumour of ovary",
          "malignant mixed mesodermal Mullerian tumour of the ovary",
          "malignant mixed mesodermal Müllerian neoplasm of ovary",
          "malignant mixed mesodermal Müllerian neoplasm of the ovary",
          "malignant mixed mesodermal Müllerian tumor of ovary",
          "malignant mixed mesodermal Müllerian tumor of the ovary",
          "malignant mixed mesodermal Müllerian tumour of ovary",
          "malignant mixed mesodermal Müllerian tumour of the ovary",
          "ovarian MMMT",
          "ovarian carcinosarcoma",
          "ovarian malignant mesodermal (Mullerian) mixed tumor",
          "ovarian malignant mesodermal (Mullerian) mixed tumour",
          "ovarian malignant mesodermal (Müllerian) mixed tumor",
          "ovarian malignant mesodermal (Müllerian) mixed tumour",
          "ovarian malignant mesodermal (mullerian) mixed tumor",
          "ovarian malignant mesodermal (mullerian) mixed tumour",
          "ovarian malignant mixed Mullerian neoplasm",
          "ovarian malignant mixed Mullerian tumor",
          "ovarian malignant mixed Mullerian tumour",
          "ovarian malignant mixed Müllerian neoplasm",
          "ovarian malignant mixed Müllerian tumor",
          "ovarian malignant mixed Müllerian tumour",
          "ovarian malignant mixed epithelial mesenchymal tumor",
          "ovarian malignant mixed epithelial mesenchymal tumour",
          "ovarian malignant mixed mesodermal (Mullerian) tumor",
          "ovarian malignant mixed mesodermal (Mullerian) tumour",
          "ovarian malignant mixed mesodermal (Müllerian) tumor",
          "ovarian malignant mixed mesodermal (Müllerian) tumour",
          "ovarian malignant mixed mesodermal Mullerian neoplasm",
          "ovarian malignant mixed mesodermal Mullerian tumor",
          "ovarian malignant mixed mesodermal Mullerian tumour",
          "ovarian malignant mixed mesodermal Müllerian neoplasm",
          "ovarian malignant mixed mesodermal Müllerian tumor",
          "ovarian malignant mixed mesodermal Müllerian tumour",
          "ovary carcinosarcoma",
          "malignant mixed Müllerian tumor of the ovary",
          "malignant mixed Müllerian tumour of the ovary",
          "ovarian carcinosarcoma/malignant mixed mesodermal tumor",
          "ovarian carcinosarcoma/malignant mixed mesodermal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A highly aggressive malignant neoplasm arising from the ovary. Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003792"
    },
    {
      "id": 5672,
      "label": "ovarian small cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2894,
        4561,
        6864
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6179",
          "EFO:1000431",
          "GARD:0010411",
          "MEDGEN:389177",
          "NCIT:C27390",
          "ONCOTREE:SCCO",
          "Orphanet:370396",
          "UMLS:C2212006"
        ],
        "synonyms": [
          "SCCO",
          "ovarian small cell NEC",
          "ovarian small cell cancer",
          "ovarian small cell carcinoma",
          "ovarian small cell neuroendocrine carcinoma",
          "ovary small cell carcinoma",
          "small cell carcinoma of ovary",
          "small cell carcinoma of the ovary",
          "small cell ovarian carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the ovary and is characterized by the presence of small malignant cells. It includes small cell carcinoma, hypercalcemic type and small cell carcinoma, pulmonary type."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003795"
    },
    {
      "id": 5875,
      "label": "ovarian seromucinous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5684,
        6864,
        7464
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6898",
          "DOID:6899",
          "GARD:0023786",
          "MEDGEN:1651770",
          "NCIT:C40090",
          "ONCOTREE:MXOV",
          "ONCOTREE:OSMCA",
          "UMLS:C0279392"
        ],
        "synonyms": [
          "malignant ovarian mixed epithelial neoplasm",
          "malignant ovarian mixed epithelial tumor",
          "malignant ovarian mixed epithelial tumour",
          "mixed epithelial carcinoma of the ovary",
          "ovarian Seromucinous carcinoma",
          "ovarian mixed epithelial carcinoma",
          "ovary mixed epithelial carcinoma",
          "mixed ovarian carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant mixed epithelial neoplasm that arises from the ovary and is composed predominantly of serous and endocervical-type mucinous epithelium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004032"
    },
    {
      "id": 7869,
      "label": "ovarian transitional cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6864,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4000",
          "EFO:1000435",
          "GARD:0024373",
          "MEDGEN:233811",
          "NCIT:C5240",
          "UMLS:C1335184"
        ],
        "synonyms": [
          "ovarian transitional cell cancer",
          "ovarian transitional cell carcinoma",
          "ovary transitional cell carcinoma",
          "transitional cell carcinoma of ovary",
          "transitional cell carcinoma of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that resemble malignant urothelial cells. There is no morphologic evidence of a benign or borderline Brenner tumor component present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006343"
    },
    {
      "id": 7974,
      "label": "undifferentiated ovarian carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6864,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000605",
          "GARD:0024428",
          "MEDGEN:83410",
          "NCIT:C4509",
          "SCTID:254856004",
          "UMLS:C0346167"
        ],
        "synonyms": [
          "anaplastic carcinoma of ovary",
          "anaplastic carcinoma of the ovary",
          "anaplastic ovarian carcinoma",
          "ovarian undifferentiated carcinoma",
          "ovary undifferentiated carcinoma",
          "undifferentiated carcinoma of ovary",
          "undifferentiated carcinoma of the ovary",
          "undifferentiated ovarian cancer",
          "undifferentiated ovarian carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive carcinoma arising from the ovary. Most patients present with advanced disease. Microscopically, it is characterized by significant cytologic atypia, increased mitotic activity, and necrosis. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006477"
    },
    {
      "id": 24239,
      "label": "familial ovarian carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6864,
        16819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6901",
          "GARD:0026259",
          "MEDGEN:272713",
          "NCIT:C36102",
          "UMLS:C1333992"
        ],
        "synonyms": [
          "hereditary ovarian cancer",
          "familial ovarian carcinoma",
          "hereditary ovarian carcinoma",
          "familiar ovarian carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Ovarian carcinoma that has developed in relatives of patients that have a history of ovarian carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100514"
    }
  ],
  "roots": [
    {
      "id": 18447,
      "label": "malignant epithelial tumor of ovary"
    }
  ]
}