{
  "id": 6868,
  "label": "familial amyotrophic lateral sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005144",
  "properties": {
    "xrefs": [
      "EFO:0001356",
      "GARD:0024155",
      "MEDGEN:1642547",
      "OMIMPS:105400",
      "UMLS:C4551993"
    ],
    "synonyms": [
      "hereditary amyotrophic lateral sclerosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An instance of amyotrophic lateral sclerosis that is caused by an inherited modification of the individual's genome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 30,
  "parents": [
    {
      "id": 6718,
      "label": "amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5143,
        19749
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:332",
          "GARD:0005786",
          "HP:0007354",
          "ICD10CM:G12.21",
          "ICD9:335.20",
          "MEDGEN:274",
          "MESH:D000690",
          "MedDRA:10002026",
          "NANDO:1200002",
          "NCIT:C34373",
          "NORD:768",
          "Orphanet:803",
          "SCTID:86044005",
          "UMLS:C0002736",
          "birnlex:12566",
          "icd11.foundation:1982355687"
        ],
        "synonyms": [
          "ALS",
          "Charcot disease",
          "Lou Gehrig disease",
          "amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004976"
    },
    {
      "id": 21302,
      "label": "hereditary motor neuron disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19749,
        21292,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019478",
          "MEDGEN:78728",
          "Orphanet:98505",
          "SCTID:49793008",
          "UMLS:C0270763"
        ],
        "synonyms": [
          "genetic anterior horn cell disease",
          "genetic motor neuron disease",
          "hereditary motor neuron disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of motor neuron disease that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 27,
      "reference_id": "MONDO:0024257"
    }
  ],
  "children": [
    {
      "id": 8516,
      "label": "amyotrophic lateral sclerosis type 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060193",
          "GARD:0024523",
          "MEDGEN:400169",
          "MESH:C531617",
          "OMIM:105400",
          "UMLS:C1862939"
        ],
        "synonyms": [
          "ALS1",
          "amyotrophic lateral sclerosis 1",
          "amyotrophic lateral sclerosis type 1",
          "FALS",
          "amyotrophic lateral sclerosis 1, autosomal dominant",
          "amyotrophic lateral sclerosis 1, autosomal dominant amyotrophic lateral sclerosis 1, autosomal recessive, included",
          "amyotrophic lateral sclerosis 1, autosomal recessive",
          "amyotrophic lateral sclerosis 1, familial",
          "amyotrophic lateral sclerosis, autosomal dominant",
          "amyotrophic lateral sclerosis, familial",
          "amyotrophic lateral sclerosis, sporadic",
          "amyotrophic lateral sclerosis, sporadic, included",
          "amyotrophic lateral sclerosis, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007103"
    },
    {
      "id": 8518,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060213",
          "GARD:0018396",
          "MEDGEN:1830423",
          "NCIT:C168756",
          "OMIM:105550",
          "UMLS:C5779877"
        ],
        "synonyms": [
          "ALSFTD",
          "C9ORF72 frontotemporal dementia with motor neuron disease",
          "C9orf72 frontotemporal dementia with motor neuron disease",
          "FTDMND",
          "amyotrophic lateral sclerosis and/or frontotemporal dementia",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 1",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis type 1",
          "frontotemporal dementia and/or motor neuron disease",
          "frontotemporal dementia with motor neuron disease caused by mutation in C9ORF72",
          "frontotemporal dementia with motor neuron disease caused by mutation in C9orf72",
          "FTDALS1",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any frontotemporal dementia with motor neuron disease in which the cause of the disease is a mutation in the C9orf72 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007105"
    },
    {
      "id": 9750,
      "label": "spinocerebellar ataxia type 2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6868,
        16361,
        19535
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050955",
          "DOID:0060204",
          "GARD:0004072",
          "MEDGEN:155704",
          "NANDO:1200046",
          "NCIT:C148315",
          "OMIM:183090",
          "Orphanet:98756",
          "SCTID:715751004",
          "UMLS:C0752121",
          "icd11.foundation:1232187870"
        ],
        "synonyms": [
          "ATXN2 autosomal dominant cerebellar ataxia type I",
          "OPCA2",
          "SCA2",
          "autosomal dominant cerebellar ataxia type I caused by mutation in ATXN2",
          "spinocerebellar ataxia type 2",
          "ALS13",
          "SCA 2",
          "Wadia swami syndrome",
          "Wadia-swami syndrome",
          "amyotrophic lateral sclerosis 13",
          "amyotrophic lateral sclerosis type 13",
          "amyotrophic lateral sclerosis, susceptibility to, 13",
          "cerebellar Degeneration with slow eye movements",
          "olivopontocerebellar atrophy 2",
          "olivopontocerebellar atrophy Holguin type",
          "olivopontocerebellar atrophy, Holguin type",
          "spinocerebellar Degeneration with slow eye movements",
          "spinocerebellar ataxia 2",
          "spinocerebellar ataxia Cuban type",
          "spinocerebellar ataxia with slow eye movements",
          "spinocerebellar ataxia, Cuban type",
          "spinocerebellar atrophy 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A subtype of type I autosomal dominant cerebellar ataxia (ADCA type I) characterized by truncal ataxia, dysarthria, slowed saccades and less commonly ophthalmoparesis and chorea."
      },
      "child_count": 3,
      "reference_id": "MONDO:0008458"
    },
    {
      "id": 11618,
      "label": "amyotrophic lateral sclerosis type 15",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060206",
          "GARD:0015269",
          "MEDGEN:477090",
          "OMIM:300857",
          "UMLS:C3275459"
        ],
        "synonyms": [
          "ALS15",
          "UBQLN2 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 15, with or without frontotemporal dementia, X-linked dominant",
          "amyotrophic lateral sclerosis caused by mutation in UBQLN2",
          "amyotrophic lateral sclerosis type 15",
          "amyotrophic lateral sclerosis 15 with or without frontotemporal dementia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the UBQLN2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010459"
    },
    {
      "id": 12067,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17505,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060208",
          "DOID:0111227",
          "GARD:0015322",
          "ICD9:331.19",
          "MEDGEN:318833",
          "MESH:C563708",
          "MESH:C579991",
          "OMIM:600795",
          "OMIM:614696",
          "SCTID:702393003",
          "UMLS:C1833296"
        ],
        "synonyms": [
          "CHMP2B amyotrophic lateral sclerosis",
          "CHMP2B-related amyotrophic lateral sclerosis",
          "FTD3",
          "amyotrophic lateral sclerosis caused by mutation in CHMP2B",
          "amyotrophic lateral sclerosis, Chmp2B-related",
          "frontotemporal dementia, chromosome 3-linked",
          "Dmt1",
          "dementia, familial nonspecific"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the CHMP2B gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010936"
    },
    {
      "id": 12343,
      "label": "amyotrophic lateral sclerosis type 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060196",
          "GARD:0010502",
          "MEDGEN:355983",
          "MESH:C566550",
          "OMIM:602433",
          "Orphanet:357043",
          "UMLS:C1865409"
        ],
        "synonyms": [
          "ALS 4",
          "ALS4",
          "SETX amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 4, juvenile",
          "amyotrophic lateral sclerosis caused by mutation in SETX",
          "dHMN with upper motor neuron signs",
          "distal hereditary motor neuropathy with upper motor neuron signs",
          "neuronopathy, distal hereditary motor, with pyramidal features"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the SETX gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011223"
    },
    {
      "id": 12727,
      "label": "amyotrophic lateral sclerosis type 21",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060212",
          "GARD:0018619",
          "MEDGEN:813851",
          "NCIT:C168755",
          "OMIM:606070",
          "UMLS:C3807521"
        ],
        "synonyms": [
          "ALS21",
          "MATR3 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis caused by mutation in MATR3",
          "amyotrophic lateral sclerosis type 21",
          "amyotrophic lateral sclerosis 21",
          "myopathy, distal, 2",
          "myopathy, distal, 2, formerly",
          "vocal cord and pharyngeal dysfunction with distal myopathy",
          "vocal cord and pharyngeal dysfunction with distal myopathy, formerly"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the MATR3 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011632"
    },
    {
      "id": 12781,
      "label": "amyotrophic lateral sclerosis type 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060195",
          "GARD:0010501",
          "MEDGEN:339829",
          "MESH:C564688",
          "OMIM:606640",
          "UMLS:C1847735"
        ],
        "synonyms": [
          "amyotrophic lateral sclerosis 3",
          "ALS3"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011691"
    },
    {
      "id": 13023,
      "label": "amyotrophic lateral sclerosis type 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060198",
          "GARD:0009874",
          "MEDGEN:419901",
          "MESH:C567699",
          "OMIM:608030",
          "UMLS:C2931786"
        ],
        "synonyms": [
          "ALS6",
          "FUS amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis caused by mutation in FUS",
          "amyotrophic lateral sclerosis 6 with or without frontotemporal dementia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the FUS gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011951"
    },
    {
      "id": 13024,
      "label": "amyotrophic lateral sclerosis type 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060199",
          "GARD:0010500",
          "MEDGEN:334136",
          "MESH:C564300",
          "OMIM:608031",
          "UMLS:C1842674"
        ],
        "synonyms": [
          "ALS7",
          "amyotrophic lateral sclerosis 7"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011952"
    },
    {
      "id": 13143,
      "label": "amyotrophic lateral sclerosis type 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050752",
          "GARD:0010499",
          "MEDGEN:325237",
          "MESH:C563895",
          "OMIM:608627",
          "UMLS:C1837728"
        ],
        "synonyms": [
          "ALS8",
          "VAPB amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 8",
          "amyotrophic lateral sclerosis caused by mutation in VAPB",
          "amyotrophic lateral sclerosis type 8"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the VAPB gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012077"
    },
    {
      "id": 13793,
      "label": "amyotrophic lateral sclerosis type 9",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060200",
          "GARD:0010498",
          "MEDGEN:395629",
          "MESH:C567499",
          "OMIM:611895",
          "UMLS:C2678468"
        ],
        "synonyms": [
          "ALS9",
          "ANG amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 9",
          "amyotrophic lateral sclerosis caused by mutation in ANG",
          "amyotrophic lateral sclerosis type 9"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the ANG gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012753"
    },
    {
      "id": 13830,
      "label": "amyotrophic lateral sclerosis type 10",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060201",
          "GARD:0015540",
          "MEDGEN:383137",
          "MESH:C567429",
          "OMIM:612069",
          "UMLS:C2677565"
        ],
        "synonyms": [
          "ALS10",
          "TARDBP amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 10, with or without FTD",
          "amyotrophic lateral sclerosis caused by mutation in TARDBP",
          "amyotrophic lateral sclerosis type 10",
          "frontotemporal lobar degeneration, TARDBP-related",
          "Ftld-TDP, Tardbp-related",
          "amyotrophic lateral sclerosis 10 with or without frontotemporal dementia",
          "frontotemporal dementia with Tdp43 inclusions, Tardbp-related",
          "frontotemporal lobar Degeneration with Tdp43 inclusions, Tardbp-related"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the TARDBP gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012790"
    },
    {
      "id": 13985,
      "label": "amyotrophic lateral sclerosis type 11",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060202",
          "GARD:0010496",
          "MEDGEN:393399",
          "MESH:C567244",
          "OMIM:612577",
          "UMLS:C2675491"
        ],
        "synonyms": [
          "ALS11",
          "FIG4 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 11",
          "amyotrophic lateral sclerosis caused by mutation in FIG4",
          "amyotrophic lateral sclerosis type 11"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the FIG4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012945"
    },
    {
      "id": 14300,
      "label": "amyotrophic lateral sclerosis type 12",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060203",
          "GARD:0015663",
          "MEDGEN:462042",
          "OMIM:613435",
          "UMLS:C3150692"
        ],
        "synonyms": [
          "ALS12",
          "OPTN amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 12",
          "amyotrophic lateral sclerosis 12 with or without frontotemporal dementia",
          "amyotrophic lateral sclerosis caused by mutation in OPTN",
          "amyotrophic lateral sclerosis type 12"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the OPTN gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013264"
    },
    {
      "id": 14531,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060205",
          "GARD:0015733",
          "MEDGEN:1759760",
          "OMIM:613954",
          "UMLS:C5436279"
        ],
        "synonyms": [
          "VCP amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis caused by mutation in VCP"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the VCP gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013501"
    },
    {
      "id": 14903,
      "label": "amyotrophic lateral sclerosis type 18",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060209",
          "GARD:0015841",
          "MEDGEN:766633",
          "OMIM:614808",
          "UMLS:C3553719"
        ],
        "synonyms": [
          "ALS18",
          "PFN1 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 18",
          "amyotrophic lateral sclerosis caused by mutation in PFN1",
          "amyotrophic lateral sclerosis type 18"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the PFN1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013891"
    },
    {
      "id": 15188,
      "label": "amyotrophic lateral sclerosis type 20",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060211",
          "GARD:0015964",
          "MEDGEN:811608",
          "OMIM:615426",
          "UMLS:C3715156"
        ],
        "synonyms": [
          "ALS20",
          "HNRNPA1 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 20",
          "amyotrophic lateral sclerosis caused by mutation in HNRNPA1",
          "amyotrophic lateral sclerosis type 20"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the HNRNPA1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014181"
    },
    {
      "id": 15229,
      "label": "amyotrophic lateral sclerosis type 19",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060210",
          "GARD:0015980",
          "MEDGEN:811607",
          "OMIM:615515",
          "UMLS:C3715155"
        ],
        "synonyms": [
          "ALS19",
          "ERBB4 amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 19",
          "amyotrophic lateral sclerosis caused by mutation in ERBB4",
          "amyotrophic lateral sclerosis type 19"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the ERBB4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014223"
    },
    {
      "id": 15397,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060214",
          "GARD:0018397",
          "MEDGEN:863085",
          "OMIM:615911",
          "UMLS:C4014648"
        ],
        "synonyms": [
          "FTDALS2",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 2",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An amyotrophic lateral sclerosis that has material basis in mutation in the CHCHD10 gene on chromosome 22. It is characterized by adult onset of either frontotemporal dementia and/or amyotrophic lateral sclerosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014395"
    },
    {
      "id": 15530,
      "label": "amyotrophic lateral sclerosis type 22",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060355",
          "GARD:0016068",
          "MEDGEN:863949",
          "OMIM:616208",
          "UMLS:C4015512"
        ],
        "synonyms": [
          "ALS 22",
          "TUBA4A amyotrophic lateral sclerosis",
          "amyotrophic lateral sclerosis 22 with or without frontotemporal dementia",
          "amyotrophic lateral sclerosis caused by mutation in TUBA4A",
          "amyotrophic lateral sclerosis type 22",
          "ALS22"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the TUBA4A gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014531"
    },
    {
      "id": 15636,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17505,
        17506,
        22128,
        25050
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110068",
          "GARD:0016113",
          "MEDGEN:897127",
          "OMIM:616437",
          "UMLS:C4225326"
        ],
        "synonyms": [
          "FTDALS3",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 3",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis type 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An amyotrophic lateral sclerosis that has material basis in mutation in the SQSTM1 gene on chromosome 5q35."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014640"
    },
    {
      "id": 15637,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        17506,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0110069",
          "GARD:0018398",
          "MEDGEN:902979",
          "OMIM:616439",
          "UMLS:C4225325"
        ],
        "synonyms": [
          "FTDALS4",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 4",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis type 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An amyotrophic lateral sclerosis that has material basis in mutation in the TBK1 gene on chromosome 12q14."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014641"
    },
    {
      "id": 17873,
      "label": "juvenile amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0011901",
          "MEDGEN:923704",
          "Orphanet:300605",
          "SCTID:718555006",
          "UMLS:C3468114"
        ],
        "synonyms": [
          "JALS",
          "juvenile Charcot disease",
          "juvenile Lou Gehrig disease",
          "amyotrophic lateral sclerosis, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Juvenile amyotrophic lateral sclerosis (JALS) is a very rare severe motor neuron disease characterized by progressive upper and lower motor neuron degeneration causing facial spasticity, dysarthria, and gait disorders with onset before 25 years of age."
      },
      "child_count": 4,
      "reference_id": "MONDO:0017593"
    },
    {
      "id": 21766,
      "label": "amyotrophic lateral sclerosis type 23",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080225",
          "GARD:0016262",
          "MEDGEN:1645924",
          "OMIM:617839",
          "UMLS:C4693381"
        ],
        "synonyms": [
          "ALS23",
          "amyotrophic lateral sclerosis 23"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0027694"
    },
    {
      "id": 22086,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018395",
          "MEDGEN:1728824",
          "OMIM:619132",
          "UMLS:C5436881"
        ],
        "synonyms": [
          "FTDALS8",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 8"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0030872"
    },
    {
      "id": 22088,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868,
        22128
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016427",
          "MEDGEN:1756201",
          "OMIM:619141",
          "UMLS:C5436884"
        ],
        "synonyms": [
          "FTDALS5",
          "frontotemporal dementia and/or amyotrophic lateral sclerosis 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0030875"
    },
    {
      "id": 22095,
      "label": "amyotrophic lateral sclerosis 26 with or without frontotemporal dementia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081380",
          "GARD:0016425",
          "MEDGEN:1771903",
          "OMIM:619133",
          "UMLS:C5436882"
        ],
        "synonyms": [
          "ALS26"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0030885"
    },
    {
      "id": 25529,
      "label": "amyotrophic lateral sclerosis 27, juvenile",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081381",
          "GARD:0026740",
          "MEDGEN:1840995",
          "OMIM:620285",
          "UMLS:C5830359"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0859529"
    },
    {
      "id": 25710,
      "label": "amyotrophic lateral sclerosis 28",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6868
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081382",
          "GARD:0026858",
          "MEDGEN:1841278",
          "OMIM:620452",
          "UMLS:C5830642"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957538"
    }
  ],
  "roots": [
    {
      "id": 6718,
      "label": "amyotrophic lateral sclerosis"
    },
    {
      "id": 21302,
      "label": "hereditary motor neuron disease"
    }
  ]
}