{
  "id": 6873,
  "label": "pulmonary hypertension",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005149",
  "properties": {
    "xrefs": [
      "DOID:6432",
      "GARD:0027347",
      "MEDGEN:9376",
      "MESH:D006976",
      "MedDRA:10037400",
      "SCTID:70995007",
      "UMLS:C0020542",
      "icd11.foundation:1496633964"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Increased pressure within the pulmonary circulation due to lung or heart disorder."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 6776,
      "label": "hypertensive disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2933
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10763",
          "EFO:0000537",
          "HP:0000822",
          "ICD10CM:I10-I16",
          "ICD10CM:I15",
          "ICD9:401-405",
          "ICD9:997.91",
          "MEDGEN:6969",
          "MESH:D006973",
          "NCIT:C3117",
          "SCTID:38341003",
          "UMLS:C0020538"
        ],
        "synonyms": [
          "HTN",
          "blood pressure, high",
          "blood pressure, increased",
          "high blood pressure",
          "hypertensive disease",
          "increased blood pressure",
          "pressure, high blood",
          "vascular hypertensive disorder",
          "hypertension"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005044"
    }
  ],
  "children": [
    {
      "id": 13100,
      "label": "Braddock syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6873,
        16089
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016652",
          "MEDGEN:333986",
          "MESH:C564244",
          "OMIM:608406",
          "Orphanet:52047",
          "SCTID:720575002",
          "UMLS:C1842082"
        ],
        "synonyms": [
          "Vater-like syndrome with pulmonary hypertension, abnormal ears and growth deficiency",
          "VATER-like defects with pulmonary hypertension, laryngeal webs, and growth deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Braddock syndrome is a rare malformation syndrome with multiple congenital abnormalities, described in 2 siblings, that is characterized by VACTERL -like association in combination with pulmonary hypertension, laryngeal webs, blue sclerae, abnormal ears, persistent growth deficiency and normal intellect."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012032"
    },
    {
      "id": 14062,
      "label": "chronic thromboembolic pulmonary hypertension",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013124",
          "ICD10CM:I27.24",
          "ICD9:415.19",
          "ICD9:416.8",
          "MEDGEN:440560",
          "MedDRA:10068739",
          "NANDO:1200429",
          "OMIM:612862",
          "Orphanet:70591",
          "SCTID:233947005",
          "UMLS:C2748504",
          "icd11.foundation:1567490107"
        ],
        "synonyms": [
          "CTEPH",
          "Cteph, Dvt-negative, susceptibility to",
          "pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by the persistence of thromboemboli in the form of organized tissue obstructing the pulmonary arteries. The consequence is an increase in pulmonary vascular resistance (PVR) resulting in pulmonary hypertension (PH) and progressive right heart failure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013024"
    },
    {
      "id": 14489,
      "label": "hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6873,
        16626,
        16918
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017569",
          "MEDGEN:462559",
          "OMIM:613845",
          "Orphanet:363694",
          "UMLS:C3151209"
        ],
        "synonyms": [
          "HUPRA syndrome",
          "hyperuricemia, pulmonary hypertension, renal failure, and alkalosis",
          "HUPRAS",
          "Hupra syndrome",
          "hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013458"
    },
    {
      "id": 16614,
      "label": "pulmonary arterial hypertension",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001361",
          "GARD:0007501",
          "MEDGEN:425404",
          "MESH:D000081029",
          "MedDRA:10064911",
          "NANDO:1200425",
          "NANDO:2100103",
          "NANDO:2200298",
          "NORD:1634",
          "Orphanet:182090",
          "Orphanet:422",
          "SCTID:11399002",
          "UMLS:C2973725",
          "icd11.foundation:1931148955"
        ],
        "synonyms": [
          "PAH",
          "pulmonary arterial hypertension",
          "PAH with overt features of venous/capillaries involvement",
          "PVOD/PCH",
          "PPH",
          "idiopathic pulmonary hypertension"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Pulmonary arterial hypertension (PAH) is a group of diseases characterized by mean pulmonary artery pressure >20 mmHg and elevated pulmonary arterial resistance leading to right heart failure. PAH is progressive and potentially fatal. PAH may be idiopathic and/ or familial, have overt features of venous/capillary involvement (pulmonary veno-occlusive disease, PVOD/pulmonary capillary hemangiomatosis, PCH), induced by drug or toxin (drug-or toxin-induced PAH), or associated with other diseases like congenital heart disease, connective tissue disease, HIV, schistosomiasis, portal hypertension (PAH associated with other disease)."
      },
      "child_count": 5,
      "reference_id": "MONDO:0015924"
    },
    {
      "id": 17504,
      "label": "pulmonary hypertension owing to lung disease and/or hypoxia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021034",
          "ICD9:416.8",
          "MEDGEN:785400",
          "Orphanet:275837",
          "SCTID:697910001",
          "UMLS:C3698136"
        ],
        "synonyms": [
          "PH due to lung disease and/or hypoxia",
          "PH owing to lung disease and/or hypoxia",
          "pulmonary hypertension due to lung disease and/or hypoxia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017157"
    },
    {
      "id": 23901,
      "label": "pulmonary hypertension, neonatal",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6873
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027371",
          "NCIT:C4732"
        ],
        "synonyms": [
          "persistent pulmonary hypertension in the newborn"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Abnormally high blood pressure in a newborn child."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100159"
    }
  ],
  "roots": [
    {
      "id": 6776,
      "label": "hypertensive disorder"
    }
  ]
}