{
  "id": 6876,
  "label": "hypopituitarism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005152",
  "properties": {
    "xrefs": [
      "DOID:9406",
      "EFO:0001380",
      "ICD10CM:E23.0",
      "MEDGEN:9386",
      "MESH:D007018",
      "NANDO:1200387",
      "NANDO:2100110",
      "NCIT:C62591",
      "SCTID:74728003",
      "UMLS:C0020635",
      "icd11.foundation:768216194"
    ],
    "synonyms": [
      "pituitary insufficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5314,
      "label": "pituitary gland disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772,
        6875,
        7209
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:53",
          "EFO:0009607",
          "ICD9:253.1",
          "ICD9:253.8",
          "ICD9:253.9",
          "MEDGEN:45934",
          "MESH:D010900",
          "NCIT:C26854",
          "SCTID:399244003",
          "UMLS:C0032002"
        ],
        "synonyms": [
          "disease of pituitary gland",
          "disease or disorder of pituitary gland",
          "disorder of pituitary gland",
          "pituitary gland disease",
          "pituitary gland disease or disorder",
          "pituitary gland disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A disease involving the pituitary gland."
      },
      "child_count": 27,
      "reference_id": "MONDO:0003381"
    }
  ],
  "children": [
    {
      "id": 14137,
      "label": "combined pituitary hormone deficiencies, genetic form",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4427,
        6876,
        16526,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010602",
          "MEDGEN:906592",
          "OMIMPS:613038",
          "Orphanet:95494",
          "SCTID:718182008",
          "UMLS:C4273747"
        ],
        "synonyms": [
          "familial congenital hypopituitarism",
          "genetic hypopituitarism",
          "multiple pituitary hormone deficiencies, genetic forms",
          "pituitary hormone deficiency, combined",
          "combined pituitary hormone deficiencies, genetic forms",
          "familial hypopituitarism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Congenital hypopituitarism is characterized by multiple pituitary hormone deficiency, including somatotroph, thyrotroph, lactotroph, corticotroph or gonadotroph deficiencies, due to mutations of pituitary transcription factors involved in pituitary ontogenesis. Congenital hypopituitarism is rare compared with the high incidence of hypopituitarism induced by pituitary adenomas, transsphenoidal surgery or radiotherapy."
      },
      "child_count": 36,
      "reference_id": "MONDO:0013099"
    },
    {
      "id": 19567,
      "label": "acquired pituitary hormone deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6876,
        16072
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019278",
          "MEDGEN:1843262",
          "NANDO:2200313",
          "Orphanet:95502",
          "UMLS:C5681569"
        ],
        "synonyms": [
          "acquired hypopituitarism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of hypopituitarism that is acquired during the lifetime of the individual."
      },
      "child_count": 8,
      "reference_id": "MONDO:0019832"
    },
    {
      "id": 21225,
      "label": "Kaplowitz-Bodurtha syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6876,
        20367
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:444037",
          "MESH:C536893",
          "UMLS:C2931361"
        ],
        "synonyms": [
          "congenital hypopituitarism and microphthalmia",
          "hypopituitarism microphthalmia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0023538"
    }
  ],
  "roots": [
    {
      "id": 5314,
      "label": "pituitary gland disorder"
    }
  ]
}