{
  "id": 6877,
  "label": "cervical adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005153",
  "properties": {
    "xrefs": [
      "DOID:3702",
      "EFO:0001416",
      "GARD:0020488",
      "MEDGEN:79024",
      "NCIT:C4029",
      "ONCOTREE:CEAD",
      "Orphanet:213772",
      "SCTID:254887002",
      "UMLS:C0279672",
      "icd11.foundation:261293318"
    ],
    "synonyms": [
      "adenocarcinoma - cervix",
      "adenocarcinoma of cervix",
      "adenocarcinoma of cervix uteri",
      "adenocarcinoma of the cervix",
      "adenocarcinoma of the cervix uteri",
      "adenocarcinoma of the uterine cervix",
      "adenocarcinoma of uterine cervix",
      "cervical adenocarcinoma",
      "cervix adenocarcinoma",
      "cervix uteri adenocarcinoma",
      "uterine cervix adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "An adenocarcinoma arising from the cervical epithelium. It accounts for approximately 15% of invasive cervical carcinomas. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors. Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement. Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    },
    {
      "id": 6855,
      "label": "cervical carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4978,
        6929
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2893",
          "EFO:0001061",
          "MEDGEN:86222",
          "NCIT:C9039",
          "SCTID:285432005",
          "UMLS:C0302592",
          "icd11.foundation:1743710977"
        ],
        "synonyms": [
          "cancer of cervix",
          "cancer of the cervix",
          "cancer of the uterine cervix",
          "cancer of uterine cervix",
          "cervical cancer",
          "cervical cancer, NOS",
          "cervix cancer",
          "uterine cervix cancer",
          "carcinoma of cervix",
          "carcinoma of cervix uteri",
          "carcinoma of the cervix",
          "carcinoma of the cervix uteri",
          "carcinoma of the uterine cervix",
          "carcinoma of uterine cervix",
          "cervical carcinoma",
          "cervix carcinoma",
          "cervix uteri carcinoma",
          "uterine cervix carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005131"
    }
  ],
  "children": [
    {
      "id": 2993,
      "label": "endocervical adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6079,
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050940",
          "GARD:0022803",
          "MEDGEN:688039",
          "NCIT:C127907",
          "ONCOTREE:ECAD",
          "SCTID:123842006",
          "UMLS:C1263762"
        ],
        "synonyms": [
          "endocervical adenocarcinoma, usual type",
          "endocervix adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the endocervix. It is the most common type of endocervical adenocarcinoma. The neoplastic epithelium shows a pseudostratified architecture and the malignant cells have enlarged, elongated, and hyperchromatic nuclei."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000554"
    },
    {
      "id": 4777,
      "label": "uterine ligament adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5505,
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3700",
          "GARD:0023228",
          "MEDGEN:311429",
          "NCIT:C40135",
          "UMLS:C1519866"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare adenocarcinoma that arises from the uterine ligament."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002741"
    },
    {
      "id": 4778,
      "label": "cervical mucinous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6700,
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3701",
          "GARD:0023229",
          "MEDGEN:232048",
          "NCIT:C36095",
          "UMLS:C1332919"
        ],
        "synonyms": [
          "cervical mucinous adenocarcinoma",
          "uterine cervix mucinous adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A usually well to moderately differentiated cervical adenocarcinoma characterized by the presence of malignant glandular cells that contain significant amount of intracytoplasmic mucin."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002742"
    },
    {
      "id": 5341,
      "label": "Wolffian duct adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6814,
        6877,
        7253,
        21611
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5368",
          "GARD:0023507",
          "MEDGEN:273908",
          "NCIT:C40254",
          "UMLS:C1516419"
        ],
        "synonyms": [
          "cervical mesonephric adenocarcinoma",
          "mesonephric duct adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A cervical adenocarcinoma that arises from mesonephric remnants. It is usually characterized by the presence of tubular glands lined by cuboidal epithelial cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003410"
    },
    {
      "id": 5520,
      "label": "cervical serous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6877,
        6974
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5752",
          "GARD:0023593",
          "MEDGEN:308950",
          "NCIT:C40201",
          "UMLS:C1516431"
        ],
        "synonyms": [
          "cervical serous adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare adenocarcinoma that arises from the cervix. It is characterized by the presence of papillary patterns and cellular budding. Psammoma bodies are often seen."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003631"
    },
    {
      "id": 5551,
      "label": "cervical endometrioid adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6760,
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5830",
          "EFO:1000164",
          "GARD:0023611",
          "MEDGEN:272450",
          "NCIT:C6343",
          "ONCOTREE:CEEN",
          "UMLS:C1332913"
        ],
        "synonyms": [
          "cervical endometrioid adenocarcinoma",
          "cervical endometrioid carcinoma",
          "cervix endometrioid adenocarcinoma",
          "cervix endometrioid carcinoma",
          "cervix uteri endometrioid adenocarcinoma",
          "cervix uteri endometrioid carcinoma",
          "endometrioid adenocarcinoma of cervix",
          "endometrioid adenocarcinoma of cervix uteri",
          "endometrioid adenocarcinoma of the cervix",
          "endometrioid adenocarcinoma of the cervix uteri",
          "endometrioid adenocarcinoma of the uterine cervix",
          "endometrioid adenocarcinoma of uterine cervix",
          "endometrioid carcinoma of cervix",
          "endometrioid carcinoma of cervix uteri",
          "endometrioid carcinoma of the cervix",
          "endometrioid carcinoma of the cervix uteri",
          "endometrioid carcinoma of the uterine cervix",
          "endometrioid carcinoma of uterine cervix",
          "uterine cervix endometrioid adenocarcinoma",
          "uterine cervix endometrioid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A cervical adenocarcinoma with the histologic characteristics of the endometrioid adenocarcinoma of the endometrium."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003665"
    },
    {
      "id": 6330,
      "label": "early invasive cervical adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8307",
          "GARD:0024051",
          "MEDGEN:232144",
          "NCIT:C36096",
          "UMLS:C1333369"
        ],
        "synonyms": [
          "cervical microinvasive adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A cervical adenocarcinoma with minimal stromal invasion. The risk of local lymph node metastasis is insignificant and the prognosis is excellent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004530"
    },
    {
      "id": 7697,
      "label": "cervical adenoid cystic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4867",
          "EFO:1000161",
          "GARD:0020498",
          "MEDGEN:232337",
          "NCIT:C6346",
          "ONCOTREE:CACC",
          "Orphanet:213823",
          "UMLS:C1332911"
        ],
        "synonyms": [
          "adenoid cystic carcinoma of cervix",
          "adenoid cystic carcinoma of cervix uteri",
          "adenoid cystic carcinoma of the cervix",
          "adenoid cystic carcinoma of the cervix uteri",
          "adenoid cystic carcinoma of the uterine cervix",
          "adenoid cystic carcinoma of uterine cervix",
          "cervical adenoid cystic cancer",
          "cervical adenoid cystic carcinoma",
          "cervix uteri adenoid cystic carcinoma",
          "uterine cervix adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare carcinoma that arises from the cervix. It is characterized by the presence of cystic spaces surrounded by palisaded epithelial cells. The cystic spaces contain eosinophilic hyaline material or mucin. Nuclear pleomorphism, necrotic changes, and a high mitotic rate are also present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006133"
    },
    {
      "id": 7698,
      "label": "cervical adenosquamous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6877,
        7652,
        7706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5636",
          "EFO:1000162",
          "GARD:0024303",
          "MEDGEN:91091",
          "NCIT:C4519",
          "ONCOTREE:CEAS",
          "SCTID:254888007",
          "UMLS:C0346202"
        ],
        "synonyms": [
          "adenosquamous cell carcinoma of cervix",
          "adenosquamous cell carcinoma of cervix uteri",
          "adenosquamous cell carcinoma of the cervix",
          "adenosquamous cell carcinoma of the cervix uteri",
          "adenosquamous cell carcinoma of the uterine cervix",
          "adenosquamous cell carcinoma of uterine cervix",
          "cervical adenosquamous cancer",
          "cervical adenosquamous carcinoma",
          "cervical adenosquamous cell carcinoma",
          "cervix adenosquamous cell carcinoma",
          "cervix uteri adenosquamous cell carcinoma",
          "uterine cervix adenosquamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An uncommon carcinoma arising from the cervix. It is composed of malignant glandular epithelial cells and malignant squamous epithelial cells."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006134"
    },
    {
      "id": 7699,
      "label": "cervical clear cell adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6742,
        6877
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5303",
          "EFO:1000163",
          "GARD:0024304",
          "MEDGEN:234113",
          "NCIT:C6344",
          "ONCOTREE:CECC",
          "UMLS:C1332912"
        ],
        "synonyms": [
          "cervical clear cell adenocarcinoma",
          "cervical clear cell carcinoma",
          "cervix clear cell adenocarcinoma",
          "cervix clear cell carcinoma",
          "cervix uteri clear cell adenocarcinoma",
          "cervix uteri clear cell carcinoma",
          "clear cell adenocarcinoma of cervix",
          "clear cell adenocarcinoma of cervix uteri",
          "clear cell adenocarcinoma of the cervix",
          "clear cell adenocarcinoma of the cervix uteri",
          "clear cell adenocarcinoma of the uterine cervix",
          "clear cell adenocarcinoma of uterine cervix",
          "clear cell carcinoma of cervix",
          "clear cell carcinoma of cervix uteri",
          "clear cell carcinoma of the cervix",
          "clear cell carcinoma of the cervix uteri",
          "clear cell carcinoma of the uterine cervix",
          "clear cell carcinoma of uterine cervix",
          "uterine cervix clear cell adenocarcinoma",
          "uterine cervix clear cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare morphologic variant of cervical adenocarcinoma composed of clear and hobnail cells. It is associated with in utero exposure to diethylstilbestrol (DES)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006135"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    },
    {
      "id": 6855,
      "label": "cervical carcinoma"
    }
  ]
}