{
  "id": 6882,
  "label": "prostate carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005159",
  "properties": {
    "xrefs": [
      "DOID:10286",
      "EFO:0001663",
      "MEDGEN:108657",
      "NCIT:C4863",
      "UMLS:C0600139"
    ],
    "synonyms": [
      "carcinoma of prostate",
      "carcinoma of prostate gland",
      "carcinoma of the prostate",
      "prostate carcinoma",
      "prostate gland carcinoma",
      "cancer of prostate",
      "cancer of the prostate",
      "prostate cancer",
      "prostate cancer, NOS"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the prostate gland."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    },
    {
      "id": 9621,
      "label": "prostate cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7450,
        20463
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10283",
          "ICD10CM:C61",
          "ICD9:185",
          "MEDGEN:138169",
          "MESH:D011471",
          "NCIT:C7378",
          "SCTID:399068003",
          "UMLS:C0376358"
        ],
        "synonyms": [
          "prostate neoplasm",
          "prostatic neoplasm",
          "tumor of the prostate",
          "tumour of the prostate",
          "cancer of prostate gland",
          "malignant neoplasm of prostate",
          "malignant neoplasm of prostate gland",
          "malignant neoplasm of the prostate",
          "malignant prostate gland neoplasm",
          "malignant prostate neoplasm",
          "malignant prostate tumor",
          "malignant prostate tumour",
          "malignant tumor of prostate",
          "malignant tumor of the prostate",
          "malignant tumour of prostate",
          "malignant tumour of the prostate",
          "prostate gland cancer",
          "hereditary prostate cancer",
          "prostate cancer, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant tumor involving the prostate gland. The vast majority are carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0008315"
    }
  ],
  "children": [
    {
      "id": 3259,
      "label": "prostate squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        6882
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10287",
          "MEDGEN:226996",
          "NCIT:C5536",
          "ONCOTREE:PRSC",
          "SCTID:399590005",
          "UMLS:C1302530"
        ],
        "synonyms": [
          "prostate gland squamous cell carcinoma",
          "prostate squamous cell carcinoma",
          "squamous cell carcinoma of prostate",
          "squamous cell carcinoma of the prostate",
          "PRSC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An invasive prostate carcinoma characterized by the presence of squamous differentiation of the malignant cellular infiltrate. There is no evidence of glandular differentiation."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000993"
    },
    {
      "id": 4852,
      "label": "primary prostate urothelial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6882,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4011",
          "GARD:0023261",
          "MEDGEN:271382",
          "NCIT:C39898",
          "UMLS:C1514430"
        ],
        "synonyms": [
          "primary prostate urothelial cancer",
          "primary prostate urothelial carcinoma",
          "prostate gland transitional cell carcinoma",
          "prostate transitional cell carcinoma",
          "prostate urothelial carcinoma",
          "transitional cell carcinoma of prostate",
          "transitional cell carcinoma of the prostate"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An urothelial carcinoma that arises from the urothelial lining of the prostatic ducts or the prostatic urethra."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002834"
    },
    {
      "id": 6699,
      "label": "metastatic prostate carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6882
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000196",
          "ICD9:199.1",
          "MEDGEN:215232",
          "NCIT:C8946",
          "SCTID:314994000",
          "UMLS:C0936223"
        ],
        "synonyms": [
          "metastatic prostate cancer",
          "metastatic prostate carcinoma",
          "prostate cancer metastatic",
          "prostate carcinoma metastatic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the prostate gland and has spread to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004956"
    },
    {
      "id": 6810,
      "label": "prostate adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6882
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2526",
          "EFO:0000673",
          "MEDGEN:764",
          "NCIT:C2919",
          "ONCOTREE:PRAD",
          "SCTID:399490008",
          "UMLS:C0007112"
        ],
        "synonyms": [
          "adenocarcinoma of prostate",
          "adenocarcinoma of the prostate",
          "prostate adenocarcinoma",
          "prostate gland adenocarcinoma",
          "prad"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the prostate gland"
      },
      "child_count": 4,
      "reference_id": "MONDO:0005082"
    },
    {
      "id": 7787,
      "label": "grade III prostatic intraepithelial neoplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6433,
        6882,
        6913
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8634",
          "EFO:1000283",
          "ICD10CM:D07.5",
          "ICD9:233.4",
          "MEDGEN:1684800",
          "NCIT:C3642",
          "SCTID:92691004",
          "UMLS:C5200982"
        ],
        "synonyms": [
          "PIN III",
          "adenocarcinoma in situ of prostate",
          "adenocarcinoma in situ of the prostate",
          "carcinoma in situ of prostate",
          "carcinoma in situ of prostate gland",
          "grade 3 pin",
          "grade 3 prostatic intraepithelial neoplasia",
          "grade III pin",
          "pin III",
          "prostate adenocarcinoma in situ",
          "prostate carcinoma in situ",
          "prostate gland carcinoma in situ",
          "prostate gland in situ carcinoma",
          "stage 0 prostate gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "High grade prostatic intraepithelial neoplasia characterized by the presence of severe architectural and cytologic abnormalities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006234"
    },
    {
      "id": 7910,
      "label": "prostate small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        4557,
        6882
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7141",
          "EFO:1000499",
          "GARD:0024395",
          "MEDGEN:266251",
          "NCIT:C6766",
          "ONCOTREE:PRSCC",
          "SCTID:396198006",
          "UMLS:C1300585"
        ],
        "synonyms": [
          "Oat cell carcinoma of prostate",
          "Oat cell carcinoma of the prostate",
          "prostate Oat cell carcinoma",
          "prostate gland small cell carcinoma",
          "prostate oat cell carcinoma",
          "prostate small cell NEC",
          "prostate small cell carcinoma",
          "prostate small cell neuroendocrine carcinoma",
          "small cell carcinoma of prostate",
          "small cell carcinoma of prostate gland",
          "small cell carcinoma of the prostate",
          "PRSCC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine carcinoma of the prostate gland with unfavorable prognosis, composed of small cells containing neurosecretory granules. Approximately half of the cases show a mixture of small cells and adenocarcinoma cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006390"
    },
    {
      "id": 21143,
      "label": "familial prostate carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6882,
        24670
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004520",
          "GTR:AN0101368",
          "GTR:AN0101369",
          "MEDGEN:1667326",
          "NCIT:C103817",
          "UMLS:C4722328"
        ],
        "synonyms": [
          "hereditary prostate carcinoma",
          "prostate cancer, familial",
          "prostate cancer, hereditary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0023122"
    },
    {
      "id": 23669,
      "label": "hormone-resistant prostate carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6882
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:858471",
          "NCIT:C114933",
          "UMLS:C3898877"
        ],
        "synonyms": [
          "hormone-resistant prostate cancer",
          "hormone-resistant prostate carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Prostate carcinoma that does not respond to hormone therapy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0056814"
    },
    {
      "id": 25212,
      "label": "castration-resistant prostate carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6882
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080909",
          "MEDGEN:730224",
          "NCIT:C130234",
          "UMLS:C1328504"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A prostate carcinoma that is characterized by continued growth and spread despite the surgical removal of the testes or medical intervention to block androgen production."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850353"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    },
    {
      "id": 9621,
      "label": "prostate cancer"
    }
  ]
}