{
  "id": 6886,
  "label": "fibrosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005164",
  "properties": {
    "xrefs": [
      "DOID:3355",
      "EFO:0002087",
      "GARD:0002327",
      "HP:0100244",
      "ICD9:171.9",
      "ICDO:8810/3",
      "MEDGEN:5178",
      "MESH:D005354",
      "MedDRA:10016632",
      "NANDO:2200060",
      "NCIT:C3043",
      "ONCOTREE:FIBS",
      "Orphanet:2030",
      "SCTID:443250000",
      "UMLS:C0016057"
    ],
    "synonyms": [
      "fibrocytic tumor",
      "fibrocytic tumour",
      "fibrosarcoma",
      "fibrosarcoma (disease)",
      "fibrosarcoma (excluding infantile fibrosarcoma)",
      "fibrosarcoma - not infantile",
      "fibrosarcoma, malignant",
      "malignant fibromatous neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A malignant mesenchymal fibroblastic neoplasm affecting the soft tissue and bone."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 7762,
      "label": "fibroblastic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4667,
        20678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000255",
          "MEDGEN:60198",
          "NCIT:C7075",
          "UMLS:C0206643"
        ],
        "synonyms": [
          "fibroblastic neoplasm",
          "fibroblastic tumor",
          "fibroblastic tumour",
          "fibrocytic neoplasm",
          "fibrocytic tumor",
          "fibrocytic tumour",
          "fibrogenic neoplasm",
          "fibrogenicTumor",
          "fibrous neoplasm",
          "fibrous tumor",
          "fibrous tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A benign, intermediate, or malignant mesenchymal neoplasm characterized by the presence of neoplastic fibroblasts."
      },
      "child_count": 14,
      "reference_id": "MONDO:0006209"
    },
    {
      "id": 18239,
      "label": "soft tissue sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816,
        21548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070663",
          "EFO:1001968",
          "GARD:0004898",
          "MEDGEN:1642116",
          "NCIT:C9306",
          "NORD:1953",
          "Orphanet:3394",
          "SCTID:424952003",
          "UMLS:C4551687"
        ],
        "synonyms": [
          "malignant soft tissue tumor",
          "malignant soft tissue tumour",
          "connective tissue sarcoma",
          "malignant mesenchymal tumor",
          "malignant mesenchymal tumour",
          "non-Rhabdo. soft tissue sarcoma",
          "sarcoma of soft tissue",
          "sarcoma of the soft tissue",
          "soft part sarcoma",
          "soft tissue sarcoma"
        ],
        "definition": "A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones."
      },
      "child_count": 92,
      "reference_id": "MONDO:0018078"
    }
  ],
  "children": [
    {
      "id": 4670,
      "label": "bone fibrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6886,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3354",
          "GARD:0023191",
          "MEDGEN:404782",
          "NCIT:C6604",
          "UMLS:C2733623"
        ],
        "synonyms": [
          "bone fibrosarcoma",
          "bone tissue fibrosarcoma (disease)",
          "fibrosarcoma of bone",
          "fibrosarcoma of the bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive malignant neoplasm arising from the bone. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002619"
    },
    {
      "id": 4724,
      "label": "conventional fibrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3517",
          "GARD:0023210",
          "MEDGEN:232393",
          "NCIT:C9429",
          "UMLS:C1333156"
        ],
        "synonyms": [
          "classic fibrosarcoma",
          "classical fibrosarcoma",
          "conventional fibrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant mesenchymal neoplasm composed of fibroblasts, and characterized by collagen production and usually a herringbone architectural pattern."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002677"
    },
    {
      "id": 4725,
      "label": "pediatric fibrosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6886,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3520",
          "GARD:0023211",
          "MEDGEN:124685",
          "NANDO:2200060",
          "NCIT:C8088",
          "UMLS:C0279981"
        ],
        "synonyms": [
          "fibrosarcoma",
          "childhood fibrosarcoma",
          "pediatric fibrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant neoplasm arising from the deep soft tissues in children. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002678"
    },
    {
      "id": 5601,
      "label": "kidney fibrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4936,
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5982",
          "GARD:0023631",
          "MEDGEN:116050",
          "NCIT:C7726",
          "UMLS:C0238208"
        ],
        "synonyms": [
          "fibrosarcoma of kidney",
          "fibrosarcoma of the kidney",
          "kidney fibrosarcoma",
          "kidney fibrosarcoma (disease)",
          "renal fibrosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive malignant neoplasm arising from the kidney. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003720"
    },
    {
      "id": 5608,
      "label": "breast fibrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4569,
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6001",
          "GARD:0023634",
          "MEDGEN:272385",
          "NCIT:C5185",
          "UMLS:C1332630"
        ],
        "synonyms": [
          "breast fibrosarcoma",
          "breast fibrosarcoma (disease)",
          "fibrosarcoma of breast",
          "fibrosarcoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive malignant neoplasm arising from the breast. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003728"
    },
    {
      "id": 5622,
      "label": "heart fibrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5289,
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6033",
          "GARD:0023645",
          "MEDGEN:232022",
          "NCIT:C5361",
          "UMLS:C1332844"
        ],
        "synonyms": [
          "Cardiac fibrosarcoma",
          "cardiac fibrosarcoma",
          "fibrosarcoma of heart",
          "fibrosarcoma of the heart",
          "heart fibrosarcoma",
          "heart fibrosarcoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A usually aggressive malignant neoplasm arising from the heart. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003742"
    },
    {
      "id": 5745,
      "label": "central nervous system fibrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4336,
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6451",
          "GARD:0023713",
          "MEDGEN:232039",
          "NCIT:C5465",
          "UMLS:C1332879"
        ],
        "synonyms": [
          "CNS fibrosarcoma",
          "central nervous system fibrosarcoma",
          "central nervous system fibrosarcoma (disease)",
          "fibrosarcoma of CNS",
          "fibrosarcoma of central nervous system",
          "fibrosarcoma of the CNS",
          "fibrosarcoma of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A usually aggressive malignant neoplasm arising from the central nervous system. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003882"
    },
    {
      "id": 5873,
      "label": "small intestinal fibrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5296,
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6880",
          "GARD:0023784",
          "MEDGEN:234788",
          "NCIT:C5336",
          "UMLS:C1335994"
        ],
        "synonyms": [
          "fibrosarcoma of small bowel",
          "fibrosarcoma of small intestine",
          "fibrosarcoma of the small bowel",
          "fibrosarcoma of the small intestine",
          "fibrosarcoma, small intestine",
          "small bowel fibrosarcoma",
          "small intestinal fibrosarcoma",
          "small intestine fibrosarcoma",
          "small intestine fibrosarcoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A usually aggressive malignant neoplasm arising from the small intestine. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004028"
    },
    {
      "id": 6242,
      "label": "liver fibrosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4487,
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8022",
          "GARD:0024003",
          "MEDGEN:232274",
          "NCIT:C5832",
          "UMLS:C1333966"
        ],
        "synonyms": [
          "fibrosarcoma of liver",
          "fibrosarcoma of the liver",
          "hepatic fibrosarcoma",
          "liver fibrosarcoma",
          "liver fibrosarcoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually aggressive malignant neoplasm arising from the liver. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004435"
    },
    {
      "id": 7815,
      "label": "low grade fibromyxoid sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024355",
          "ICD9:171.9",
          "MEDGEN:224814",
          "NCIT:C45202",
          "ONCOTREE:LGFMS",
          "SCTID:404088004",
          "UMLS:C1275282"
        ],
        "synonyms": [
          "low grade fibromyxoid sarcoma",
          "low-grade fibromyxoid sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A low grade, late-metastasizing variant of fibrosarcoma characterized by alternating fibrous and myxoid areas and a whorling growth pattern. The neoplastic cells have a spindle morphology, and lack hyperchromasia or significant nuclear atypia. Approximately 40% of cases show the focal presence of collagen rosettes. A t(7;16)(q33;p11) translocation has been identified in the majority of cases, associated with the presence of FUS-CREB3L2 fusion protein. Rare cases carry the t(11;16)(p11;p11) translocation which is associated with the presence of the FUS-CREB3L1 fusion protein."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006272"
    },
    {
      "id": 13008,
      "label": "dermatofibrosarcoma protuberans",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6886
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3507",
          "GARD:0009569",
          "ICDO:8832/3",
          "MEDGEN:811326",
          "MESH:D018223",
          "MedDRA:10057070",
          "NCIT:C4683",
          "OMIM:607907",
          "ONCOTREE:DFSP",
          "Orphanet:31112",
          "SCTID:276799004",
          "UMLS:C3693482",
          "icd11.foundation:1579898301"
        ],
        "synonyms": [
          "DFSP",
          "dermatofibrosarcoma",
          "dermatofibrosarcoma protuberans",
          "familial dermatofibrosarcoma protuberans (subtype)",
          "giant cell fibroblastoma",
          "metastatic dermatofibrosarcoma protuberans (subtype)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Dermatofibrosarcoma protuberans (DFSP) is a rare infiltrating soft tissue sarcoma, generally of low grade malignancy, arising from the dermis of the skin and characteristically associated with a specific chromosomal translocation t(17;22)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0011934"
    }
  ],
  "roots": [
    {
      "id": 7762,
      "label": "fibroblastic neoplasm"
    },
    {
      "id": 18239,
      "label": "soft tissue sarcoma"
    }
  ]
}