{
  "id": 6891,
  "label": "neoplasm of mature T-cells or NK-cells",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005169",
  "properties": {
    "xrefs": [
      "EFO:0002426",
      "GARD:0024159",
      "MEDGEN:233675",
      "NCIT:C27909",
      "ONCOTREE:MTNN",
      "UMLS:C1334640"
    ],
    "synonyms": [
      "mature T and NK neoplasms",
      "mature T-cell and NK-cell neoplasm",
      "mature T-cell neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 21530,
      "label": "T-cell and NK-cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009622",
          "MEDGEN:277781",
          "NCIT:C27908",
          "UMLS:C1336554"
        ],
        "synonyms": [
          "T-cell and NK-cell neoplasm",
          "T-cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0024615"
    }
  ],
  "children": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6891,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050743",
          "DOID:0050749",
          "GARD:0007368",
          "ICD10CM:C84.4",
          "ICDO:9702/3",
          "MEDGEN:1790498",
          "MESH:D016411",
          "NCIT:C3468",
          "SCTID:109977009",
          "UMLS:C5551485"
        ],
        "synonyms": [
          "PTCL",
          "mature T-and NK-cell lymphoma",
          "mature T-cell and NK-cell lymphoma",
          "mature T-cell and NK-cell non-Hodgkin lymphoma",
          "mature T-cell and NK-cell non-Hodgkin's lymphoma",
          "mature T-cell lymphoma",
          "mature T-cell non-Hodgkin's lymphoma",
          "peripheral T-cell lymphoma",
          "NK-T cell lymphoma",
          "mature T-cell and natural killer cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000430"
    },
    {
      "id": 6055,
      "label": "chronic lymphoproliferative disorder of NK-cells",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6891
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7465",
          "GARD:0022072",
          "ICDO:9831/3",
          "MEDGEN:268922",
          "NCIT:C39591",
          "Orphanet:512017",
          "SCTID:722955006",
          "UMLS:C1512709",
          "icd11.foundation:921755282"
        ],
        "synonyms": [
          "CLPD-NK",
          "CNKL",
          "NK-LGL leukaemia",
          "NK-LGL leukemia",
          "NK-LGLL",
          "NK-cell large granular lymphocyte lymphocytosis",
          "NK-cell lineage granular lymphocyte proliferative disorder",
          "NK-type lymphoproliferative disorder of granular lymphocytes",
          "chronic NK lymphocytosis",
          "chronic NK-LGL lymphoproliferative disorder",
          "chronic NK-cell lymphocytosis",
          "chronic NK-large granular lymphocyte lymphoproliferative disorder",
          "chronic lymphoproliferative disorder of NK-cells",
          "indolent NK-cell lymphoproliferative disorder",
          "indolent large granular NK-cell lymphoproliferative disorder",
          "natural killer-cell large granular lymphocyte leukaemia",
          "natural killer-cell large granular lymphocyte leukemia",
          "chronic lymphoproliferative disorder of natural killer cells"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An Epstein-Barr virus negative disorder with a chronic clinical course affecting predominantly adults and characterized by the proliferation of large granular lymphocytes with natural killer cell immunophenotype. The T-cell receptor genes are not rearranged."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004234"
    },
    {
      "id": 6707,
      "label": "peripheral T-cell lymphoma, not otherwise specified",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6792,
        6891
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000211",
          "GARD:0027711",
          "NANDO:2200028",
          "NCIT:C4340",
          "ONCOTREE:PTCL",
          "icd11.foundation:855224800"
        ],
        "synonyms": [
          "peripheral T-cell lymphoma, not otherwise specified",
          "PTCL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Aggressive nodal or extranodal mature (peripheral) T-cell lymphomas that do not belong to the better defined entities of the remainder of mature T-cell lymphomas. This category includes the following variants: lymphoepithelioid cell variant (Lennert's lymphoma), follicular variant, and T-zone variant."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004964"
    },
    {
      "id": 7744,
      "label": "EBV-positive T-cell lymphoproliferative disorder of childhood",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6569,
        6891
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024323",
          "MEDGEN:397515",
          "NCIT:C80373",
          "UMLS:C2699838"
        ],
        "synonyms": [
          "EBV-positive T-cell lymphoproliferative disease of childhood",
          "EBV-positive T-cell lymphoproliferative disorder of childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An Epstein-Barr virus-associated mature T-cell lymphoproliferative group of disorders affecting children. It occurs with increased frequency in Asians and Native Americans. It includes the systemic EBV-positive T-cell lymphoma of childhood and the hydroa vacciniforme-like lymphoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006188"
    }
  ],
  "roots": [
    {
      "id": 21530,
      "label": "T-cell and NK-cell neoplasm"
    }
  ]
}