{
  "id": 6892,
  "label": "myeloid neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005170",
  "properties": {
    "xrefs": [
      "DOID:0070004",
      "EFO:0002427",
      "GARD:0024160",
      "ICDO:9975/1",
      "MEDGEN:445430",
      "NCIT:C9290",
      "ONCOTREE:MYELOID",
      "UMLS:C2939461"
    ],
    "synonyms": [
      "myeloid malignancy",
      "myeloid neoplasm",
      "myeloid tumor",
      "myeloid tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Proliferation of myeloid cells originating from a primitive stem cell."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 23467,
      "label": "hematopoietic and lymphoid cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025916",
          "MEDGEN:91264",
          "NCIT:C27134",
          "UMLS:C0376544"
        ],
        "synonyms": [
          "HEMOLYMPHORETICULAR tumor, malignant",
          "haematological neoplasm",
          "haematological tumour",
          "haematopoietic and lymphoid neoplasms",
          "haematopoietic cancer",
          "haematopoietic cell tumour",
          "haematopoietic malignancy, NOS",
          "haematopoietic neoplasm",
          "haematopoietic neoplasms including lymphomas",
          "haematopoietic tumour",
          "hematologic cancer",
          "hematologic malignancy",
          "hematologic neoplasm",
          "hematological neoplasm",
          "hematological tumor",
          "hematopoietic and lymphoid cell neoplasm",
          "hematopoietic and lymphoid neoplasms",
          "hematopoietic cancer",
          "hematopoietic cell tumor",
          "hematopoietic malignancy, NOS",
          "hematopoietic neoplasm",
          "hematopoietic neoplasms including lymphomas",
          "hematopoietic tumor",
          "hematopoietic, Including myeloma",
          "malignant haematopoietic neoplasm",
          "malignant hematologic neoplasm",
          "malignant hematopoietic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes."
      },
      "child_count": 8,
      "reference_id": "MONDO:0044881"
    }
  ],
  "children": [
    {
      "id": 4762,
      "label": "mast cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6892
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3664",
          "EFO:0009000",
          "GARD:0023222",
          "ICD9:238.79",
          "MEDGEN:83178",
          "NCIT:C9295",
          "SCTID:414653009",
          "UMLS:C0334664"
        ],
        "synonyms": [
          "Mast cell proliferative disease",
          "Mast cell tumor",
          "Mast cell tumour",
          "mast cell neoplasm",
          "mast cell tumor",
          "mast cell tumour",
          "neoplasm of Mast cells",
          "neoplasm of the Mast cells",
          "tumor of Mast cells",
          "tumor of the Mast cells",
          "tumour of Mast cells",
          "tumour of the Mast cells"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A heterogeneous group of disorders characterized by the abnormal growth and accumulation of mast cells in one or more organ systems. Recent data suggest that most variants of mast cell neoplasms are clonal disorders. (WHO, 2001)"
      },
      "child_count": 2,
      "reference_id": "MONDO:0002724"
    },
    {
      "id": 10907,
      "label": "plasma cell myeloma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3028,
        6702,
        6892
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9538",
          "EFO:0001378",
          "GARD:0007108",
          "ICD10CM:C90.0",
          "ICD9:203.0",
          "ICDO:9732/3",
          "MEDGEN:10122",
          "MESH:D009101",
          "MedDRA:10028228",
          "NCIT:C3242",
          "NORD:1469",
          "OMIM:254500",
          "ONCOTREE:PCM",
          "Orphanet:29073",
          "UMLS:C0026764",
          "icd11.foundation:1582389689",
          "icd11.foundation:526287100"
        ],
        "synonyms": [
          "Kahler disease",
          "Kahler's disease",
          "Multiple Myeloma",
          "medullary plasmacytoma",
          "multiple myeloma",
          "multiple myeloma, resistance to, Somatic mutation",
          "multiple myeloma, susceptibility to, Somatic mutation",
          "multiple myeloma/plasma cell myeloma",
          "myeloid neoplasm of plasma cell",
          "myeloma",
          "myeloma, multiple",
          "myeloma, plasma cell, malignant",
          "myelomatosis",
          "plasma cell myeloid neoplasm",
          "plasma cell myeloma",
          "Al amyloidosis",
          "amyloidosis, systemic",
          "myeloma - multiple"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)"
      },
      "child_count": 9,
      "reference_id": "MONDO:0009693"
    },
    {
      "id": 19292,
      "label": "CD4+/CD56+ hematodermic neoplasm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4907,
        6892,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081076",
          "EFO:0010580",
          "GARD:0010556",
          "ICD10CM:C86.4",
          "ICD9:202.80",
          "ICDO:9727/3",
          "MEDGEN:220972",
          "NCIT:C7203",
          "ONCOTREE:BPDCN",
          "Orphanet:86870",
          "SCTID:445105005",
          "UMLS:C1301363",
          "icd11.foundation:783045723"
        ],
        "synonyms": [
          "BPDCN",
          "CD4+/CD56+ hematodermic neoplasm",
          "agranular CD4+ CD56+ hematodermic neoplasm/tumor",
          "agranular CD4+ natural Killer cell leukaemia",
          "agranular CD4+ natural Killer cell leukemia",
          "blastic NK-cell lymphoma",
          "blastic natural Killer leukemia/lymphoma",
          "blastic plasmacytoid Dendritic cell neoplasm",
          "blastic plasmacytoid dendritic cell neoplasm",
          "early plasmacytoid Dendritic cell leukemia/lymphoma",
          "lymphoblastoid variant of NK-cell lymphoma",
          "monomorphic NK-cell lymphoma",
          "primary cutaneous CD4+/CD56+ hematolymphoid neoplasm",
          "blastic plasmacytoid dendritic cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aggressive immature hematologic neoplasm formerly known as blastic NK cell lymphoma, composed of cells with a lymphoblast-like morphology. Recent evidence suggests derivation from a plasmacytoid monocyte. Patients present with cutaneous tumors and bone marrow involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019467"
    },
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6892,
        16513,
        20376
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2226",
          "EFO:0002428",
          "GARD:0009319",
          "ICD9:238.79",
          "ICDO:9960/3",
          "ICDO:9975/1",
          "MEDGEN:220955",
          "MedDRA:10028576",
          "NCIT:C4345",
          "ONCOTREE:MPN",
          "Orphanet:98274",
          "SCTID:425333006",
          "UMLS:C1292778"
        ],
        "synonyms": [
          "CMPD",
          "MPD",
          "MPN",
          "chronic myeloproliferative disease",
          "chronic myeloproliferative disorder",
          "chronic myeloproliferative neoplasm",
          "myeloproliferative disorder",
          "myeloproliferative neoplasm",
          "myeloproliferative neoplasm, chronic",
          "myeloproliferative tumor",
          "myeloproliferative tumour",
          "CMPD, U",
          "chronic myeloproliferative disorders",
          "myeloproliferative neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)"
      },
      "child_count": 39,
      "reference_id": "MONDO:0020076"
    }
  ],
  "roots": [
    {
      "id": 23467,
      "label": "hematopoietic and lymphoid cell neoplasm"
    }
  ]
}