{
  "id": 6901,
  "label": "Parkinson disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005180",
  "properties": {
    "xrefs": [
      "DOID:14330",
      "ICD10CM:G20",
      "ICD10WHO:G20",
      "ICD9:332",
      "ICD9:332.0",
      "MEDGEN:10590",
      "MESH:D010300",
      "NANDO:1200010",
      "NCIT:C26845",
      "OMIMPS:168600",
      "Orphanet:319705",
      "SCTID:49049000",
      "UMLS:C0030567",
      "birnlex:2098",
      "icd11.foundation:296066191"
    ],
    "synonyms": [
      "PD",
      "Parkinson disease",
      "Parkinson's disease",
      "paralysis agitans"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 20335,
      "label": "parkinsonian disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5849
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080855",
          "MEDGEN:66079",
          "MESH:D020734",
          "UMLS:C0242422"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA."
      },
      "child_count": 21,
      "reference_id": "MONDO:0021095"
    },
    {
      "id": 24270,
      "label": "hereditary neurological disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6799
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "neurogenetic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology characterized by abnormalities in the brain, spinal cord, nerves, or muscles."
      },
      "child_count": 528,
      "reference_id": "MONDO:0100545"
    }
  ],
  "children": [
    {
      "id": 9508,
      "label": "late-onset Parkinson disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6901
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060892",
          "GARD:0017684",
          "MEDGEN:463618",
          "OMIM:168600",
          "Orphanet:411602",
          "SCTID:716662004",
          "UMLS:C3160718"
        ],
        "synonyms": [
          "LOPD",
          "PARK",
          "PD",
          "Parkinson disease, age of onset, modifier, Multifactorial",
          "Parkinson disease, late-onset",
          "Parkinson disease, late-onset, susceptibility to, Multifactorial",
          "Parkinson disease, susceptibility to, Multifactorial",
          "autosomal dominant late-onset Parkinson disease",
          "hereditary late onset Parkinson disease",
          "hereditary late-onset Parkinson disease",
          "late-onset Parkinson disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A Parkinson disease that begins after around the age of 50."
      },
      "child_count": 7,
      "reference_id": "MONDO:0008199"
    },
    {
      "id": 11034,
      "label": "parkinsonian-pyramidal syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6901
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060372",
          "GARD:0009175",
          "MEDGEN:337969",
          "MESH:C538104",
          "OMIM:260300",
          "Orphanet:171695",
          "UMLS:C1850100",
          "icd11.foundation:1128311778"
        ],
        "synonyms": [
          "Pallidopyramidal syndrome",
          "Parkinson disease 15, autosomal recessive",
          "autosomal recessive early-onset Parkinson disease type 15",
          "pallidopyramidal syndrome",
          "parkinsonian-pyramidal syndrome",
          "PARK15",
          "Parkinson disease 15, autosomal recessive early-onset",
          "autosomal recessive early-onset Parkinson's disease 15",
          "pallido-pyramidal disease",
          "pallido-pyramidal syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A Parkinson's disease that has material basis in mutation in the FBXO7 gene on chromosome 22q12.3."
      },
      "child_count": 1,
      "reference_id": "MONDO:0009830"
    },
    {
      "id": 11933,
      "label": "Parkinson disease, mitochondrial",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6901
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:333199",
          "MESH:C564015",
          "OMIM:556500",
          "UMLS:C1838867"
        ],
        "synonyms": [
          "Parkinson disease, mitochondrial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0010796"
    },
    {
      "id": 14203,
      "label": "Parkinson disease 16",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6901
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:442620",
          "MESH:C567726",
          "OMIM:613164",
          "UMLS:C2751012"
        ],
        "synonyms": [
          "PARK16",
          "Parkinson disease 16"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0013167"
    },
    {
      "id": 17603,
      "label": "young-onset Parkinson disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6901
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060894",
          "GARD:0016610",
          "MEDGEN:907947",
          "Orphanet:2828",
          "SCTID:715345007",
          "UMLS:C4275179"
        ],
        "synonyms": [
          "YOPD",
          "early-onset Parkinson disease",
          "early-onset Parkinson's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms."
      },
      "child_count": 9,
      "reference_id": "MONDO:0017279"
    },
    {
      "id": 25726,
      "label": "Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6901
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070486",
          "MEDGEN:1845571",
          "OMIM:620482",
          "UMLS:C5882680"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0957576"
    }
  ],
  "roots": [
    {
      "id": 20335,
      "label": "parkinsonian disorder"
    },
    {
      "id": 24270,
      "label": "hereditary neurological disease"
    }
  ]
}