{
  "id": 6905,
  "label": "pancreatic ductal adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005184",
  "properties": {
    "xrefs": [
      "DOID:3498",
      "DOID:3587",
      "EFO:0002517",
      "GARD:0027716",
      "ICD9:157.3",
      "MEDGEN:277490",
      "MESH:D021441",
      "NCIT:C9120",
      "UMLS:C1335302",
      "icd11.foundation:581089833"
    ],
    "synonyms": [
      "ductal adenocarcinoma of pancreas",
      "ductal adenocarcinoma of the pancreas",
      "pancreas ductal adenocarcinoma",
      "pancreas tubular adenocarcinoma",
      "pancreatic duct adenocarcinoma",
      "pancreatic ductal adenocarcinoma",
      "pancreatic ductal carcinoma",
      "pancreatic tubular adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An infiltrating adenocarcinoma that arises from the epithelial cells of the pancreas. It affects males more often than females and the patients are usually over 50 years of age. Microscopically it is characterized by the presence of glandular (ductal) differentiation and desmoplastic stroma formation. Signs and symptoms include pain, loss of weight, and jaundice. It grows rapidly and is usually detected after it has metastasized to other anatomic sites. The prognosis is usually poor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 7247,
      "label": "tubular adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4929",
          "EFO:0006500",
          "ICDO:8211/3",
          "MEDGEN:61428",
          "NCIT:C65192",
          "UMLS:C0205645"
        ],
        "synonyms": [
          "carcinoma, tubular cell, malignant",
          "tubular adenocarcinoma",
          "tubular adenocarcinoma (morphologic abnormality)"
        ],
        "definition": "An infiltrating adenocarcinoma in which the malignant cells form tubular structures. Representative examples include the tubular breast carcinoma and the gastric tubular adenocarcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005606"
    },
    {
      "id": 7633,
      "label": "pancreatic adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6912
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4074",
          "EFO:1000044",
          "GARD:0027736",
          "MEDGEN:83800",
          "NCIT:C8294",
          "ONCOTREE:PAAD",
          "SCTID:700423003",
          "UMLS:C0281361",
          "icd11.foundation:1663659989"
        ],
        "synonyms": [
          "adenocarcinoma - pancreas",
          "adenocarcinoma of pancreas",
          "adenocarcinoma of the pancreas",
          "pancreas adenocarcinoma",
          "pancreatic adenocarcinoma",
          "PAAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the pancreas"
      },
      "child_count": 10,
      "reference_id": "MONDO:0006047"
    }
  ],
  "children": [
    {
      "id": 4715,
      "label": "pancreatic signet ring cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6819,
        6905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3497",
          "GARD:0027610",
          "MEDGEN:233834",
          "NCIT:C5720",
          "UMLS:C1335317"
        ],
        "synonyms": [
          "pancreas signet ring cell carcinoma",
          "pancreatic signet Ring cell carcinoma",
          "pancreatic signet ring cell carcinoma",
          "signet Ring cell carcinoma of pancreas",
          "signet Ring cell carcinoma of the pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare pancreatic ductal adenocarcinoma with poor prognosis. It is characterized by the presence of malignant signet ring cells infiltrating the pancreatic parenchyma in an individual cell pattern."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002666"
    },
    {
      "id": 6104,
      "label": "pancreatic foamy gland adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7577",
          "GARD:0027674",
          "MEDGEN:235450",
          "NCIT:C37256",
          "UMLS:C1335303"
        ],
        "synonyms": [
          "pancreatic foamy gland adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pancreatic ductal adenocarcinoma characterized by the presence of adenocarcinoma cells with foamy cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004287"
    },
    {
      "id": 6156,
      "label": "mixed ductal-endocrine carcinoma of pancreas",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7716",
          "GARD:0027676",
          "MEDGEN:266254",
          "NCIT:C6879",
          "UMLS:C1301048"
        ],
        "synonyms": [
          "mixed ductal-endocrine carcinoma of the pancreas",
          "mixed ductal-neuroendocrine carcinoma of the pancreas",
          "mixed ductal-endocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the pancreas showing a mixture of ductal and neuroendocrine malignant cells in both the primary tumor and in the metastatic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004340"
    },
    {
      "id": 6157,
      "label": "colloid carcinoma of the pancreas",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6700,
        6905
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7717",
          "GARD:0027677",
          "MEDGEN:232082",
          "NCIT:C37214",
          "UMLS:C1333081"
        ],
        "synonyms": [
          "colloid carcinoma of the pancreas",
          "mucinous Noncystic carcinoma",
          "pancreatic mucinous Noncystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An infiltrating pancreatic ductal adenocarcinoma, characterized by the presence of malignant cells floating in pools of mucin. It has a more favorable prognosis than the conventional infiltrating ductal adenocarcinoma. It often arises in association with intraductal pancreatic mucinous neoplasms and in some cases it may result in the development of pseudomyxoma peritonei."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004341"
    },
    {
      "id": 7975,
      "label": "undifferentiated pancreatic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6905,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000606",
          "GARD:0027757",
          "MEDGEN:237030",
          "NCIT:C5722",
          "ONCOTREE:UCP",
          "UMLS:C1336861"
        ],
        "synonyms": [
          "pancreas undifferentiated carcinoma",
          "pancreatic carcinosarcoma",
          "pleomorphic large cell pancreatic carcinoma",
          "sarcomatoid pancreatic carcinoma",
          "spindle cell pancreatic carcinoma",
          "undifferentiated (anaplastic) pancreatic carcinoma",
          "undifferentiated carcinoma of pancreas",
          "undifferentiated carcinoma of the pancreas",
          "undifferentiated pancreatic carcinoma",
          "UCP"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma with poor prognosis that arises from the pancreas. It is characterized by the presence of a significant malignant component that does not show differentiation. The malignant cells represent a mixture of large, pleomorphic cells and giant cells, or adenocarcinoma cells and spindle cells, or spindle cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006478"
    }
  ],
  "roots": [
    {
      "id": 7247,
      "label": "tubular adenocarcinoma"
    },
    {
      "id": 7633,
      "label": "pancreatic adenocarcinoma"
    }
  ]
}