{
  "id": 6912,
  "label": "exocrine pancreatic carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005192",
  "properties": {
    "xrefs": [
      "DOID:4905",
      "EFO:0002618",
      "GARD:0027717",
      "MEDGEN:65917",
      "NCIT:C3850",
      "SCTID:372142002",
      "UMLS:C0235974"
    ],
    "synonyms": [
      "cancer of pancreas",
      "cancer of the pancreas",
      "exocrine cancer",
      "pancreas cancer",
      "pancreatic cancer",
      "carcinoma of exocrine pancreas",
      "carcinoma of the pancreas",
      "exocrine pancreas carcinoma",
      "pancreas carcinoma",
      "pancreatic cancer (not islets)",
      "pancreatic carcinoma, familial"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the exocrine pancreas"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4251,
      "label": "malignant exocrine pancreas neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11035,
        20317
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1795",
          "GARD:0027598",
          "MEDGEN:91108",
          "NCIT:C7430",
          "SCTID:255088001",
          "UMLS:C0346648"
        ],
        "synonyms": [
          "pancreatic exocrine tumor",
          "pancreatic exocrine tumour",
          "cancer of exocrine pancreas",
          "exocrine pancreas cancer",
          "malignant exocrine pancreas neoplasm",
          "malignant exocrine pancreas tumor",
          "malignant exocrine pancreas tumour",
          "malignant neoplasm of exocrine pancreas",
          "malignant neoplasm of the exocrine pancreas",
          "malignant tumor of exocrine pancreas",
          "malignant tumor of the exocrine pancreas",
          "malignant tumour of the exocrine pancreas",
          "tumor of exocrine pancreas",
          "tumour of exocrine pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the epithelial cells of the exocrine pancreatic tissue."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002116"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4587,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050922",
          "EFO:1000218",
          "HP:0002672",
          "MEDGEN:57467",
          "NCIT:C96963",
          "UMLS:C0151544"
        ],
        "synonyms": [
          "carcinoma of digestive system",
          "carcinoma of the gastrointestinal system",
          "digestive system carcinoma",
          "gastrointestinal carcinoma",
          "gastrointestinal carcinoma (disease)",
          "gastrointestinal system carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0006181"
    }
  ],
  "children": [
    {
      "id": 6102,
      "label": "pancreatic intraductal papillary-mucinous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6912
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7574",
          "GARD:0021779",
          "MEDGEN:235451",
          "NCIT:C5725",
          "Orphanet:424058",
          "UMLS:C1335304",
          "icd11.foundation:2086328209"
        ],
        "synonyms": [
          "intraductal papillary mucinous carcinoma of pancreas",
          "intraductal papillary-mucinous carcinoma of pancreas",
          "pancreatic intraductal papillary mucinous carcinoma",
          "pancreatic intraductal papillary-mucinous carcinoma",
          "intraductal papillary-colloid carcinoma of pancreas",
          "intraductal papillary-colloid carcinoma of the pancreas",
          "intraductal papillary-colloidal carcinoma of pancreas",
          "intraductal papillary-colloidal carcinoma of the pancreas",
          "intraductal papillary-mucinous carcinoma of the pancreas",
          "pancreatic intraductal papillary-colloid carcinoma",
          "pancreatic intraductal papillary-colloidal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant glandular neoplasm arising from the exocrine pancreas. Microscopically it is characterized by the presence of mucoid stroma formation, papillary patterns, and cystic changes. It has been associated with KRAS and Tp53 gene mutations."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004285"
    },
    {
      "id": 7633,
      "label": "pancreatic adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6912
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4074",
          "EFO:1000044",
          "GARD:0027736",
          "MEDGEN:83800",
          "NCIT:C8294",
          "ONCOTREE:PAAD",
          "SCTID:700423003",
          "UMLS:C0281361",
          "icd11.foundation:1663659989"
        ],
        "synonyms": [
          "adenocarcinoma - pancreas",
          "adenocarcinoma of pancreas",
          "adenocarcinoma of the pancreas",
          "pancreas adenocarcinoma",
          "pancreatic adenocarcinoma",
          "PAAD"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the pancreas"
      },
      "child_count": 10,
      "reference_id": "MONDO:0006047"
    },
    {
      "id": 7873,
      "label": "pancreatic large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6787,
        6912,
        7497
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000442",
          "GARD:0024376",
          "MEDGEN:459465",
          "NCIT:C95582",
          "UMLS:C2987239"
        ],
        "synonyms": [
          "large cell neuroendocrine carcinoma of pancreas",
          "pancreas large cell neuroendocrine carcinoma",
          "pancreatic large cell NEC",
          "pancreatic large cell NEC G3",
          "pancreatic large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant large cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006347"
    },
    {
      "id": 16160,
      "label": "familial pancreatic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6912
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004206",
          "MEDGEN:419700",
          "MESH:C535837",
          "NCIT:C43298",
          "OMIM:260350",
          "Orphanet:1333",
          "SCTID:715414009",
          "UMLS:C2931038",
          "icd11.foundation:1385362916"
        ],
        "synonyms": [
          "familial pancreatic cancer",
          "familial pancreatic carcinoma",
          "hereditary exocrine pancreatic carcinoma",
          "hereditary pancreatic cancer",
          "hereditary pancreatic carcinoma",
          "pancreatic cancer, somatic",
          "pancreatic carcinoma, somatic",
          "pancreatic acinar carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Familial pancreatic carcinoma is defined by the presence of pancreatic cancer (PC) in two or more first-degree relatives."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015278"
    },
    {
      "id": 18547,
      "label": "squamous cell carcinoma of pancreas",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        6912
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080323",
          "GARD:0021776",
          "MEDGEN:393937",
          "NCIT:C173813",
          "Orphanet:424039",
          "UMLS:C2675993"
        ],
        "synonyms": [
          "pancreas squamous cell carcinoma",
          "pancreatic squamous cell carcinoma",
          "squamous cell carcinoma of the pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the pancreas."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018521"
    },
    {
      "id": 18548,
      "label": "pancreatic mucinous cystadenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4835,
        6912,
        8302,
        20031
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7235",
          "DOID:7735",
          "GARD:0021778",
          "MEDGEN:277492",
          "NCIT:C5718",
          "Orphanet:424053",
          "UMLS:C1335309"
        ],
        "synonyms": [
          "pancreas mucinous cystadenoma",
          "pancreatic mucinous cystadenoma",
          "colloid cystadenoma of pancreas",
          "colloid cystadenoma of the pancreas",
          "colloidal cystadenoma of pancreas",
          "colloidal cystadenoma of the pancreas",
          "mucinous cystadenocarcinoma of the pancreas",
          "mucinous cystadenoma of the pancreas",
          "pancreatic colloid cystadenoma",
          "pancreatic colloidal cystadenoma",
          "pancreatic mucinous cystadenocarcinoma",
          "pancreatic mucinous cystic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-metastasizing cystic epithelial neoplasm arising from the exocrine pancreas. It is composed of columnar, mucin-producing epithelial cells. It occurs almost exclusively in women. Large tumors are often accompanied by a palpable abdominal mass."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018523"
    },
    {
      "id": 18549,
      "label": "solid pseudopapillary carcinoma of pancreas",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6912
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6827",
          "GARD:0021780",
          "ICDO:8452/3",
          "MEDGEN:236832",
          "NCIT:C5728",
          "Orphanet:424065",
          "UMLS:C1336029"
        ],
        "synonyms": [
          "solid pseudopapillary neoplasm of the pancreas",
          "pancreatic solid pseudopapillary carcinoma",
          "solid pseudopapillary carcinoma of pancreas",
          "solid pseudopapillary carcinoma of the pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm arising from the exocrine pancreas. It occurs predominantly in young women. It is characterized by the presence of extensive necrosis and hemorrhage and is composed of polyhedral cells forming solid and pseudopapillary patterns. There is morphologic evidence of perineural invasion, vascular invasion, or extensive invasion into the surrounding tissues."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018525"
    },
    {
      "id": 23412,
      "label": "pancreatic carcinoma with mixed differentiation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6912,
        7739
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022057",
          "MEDGEN:353935",
          "NCIT:C45843",
          "Orphanet:506112",
          "UMLS:C1709050"
        ],
        "synonyms": [
          "MiNEN of pancreas",
          "mixed exocrine-endocrine carcinoma of the pancreas",
          "pancreatic MiNEN",
          "pancreatic carcinoma with mixed differentiation",
          "pancreatic mixed neuroendocrine-nonneuroendocrine neoplasm",
          "mixed neuroendocrine-nonneuroendocrine neoplasm of pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare carcinoma with a poor prognosis, characterized by the presence of a mixture of exocrine and neuroendocrine malignant epithelial cells in both the pancreas and metastatic sites. Symptoms include jaundice, abdominal pain, and weight loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044727"
    }
  ],
  "roots": [
    {
      "id": 4251,
      "label": "malignant exocrine pancreas neoplasm"
    },
    {
      "id": 7738,
      "label": "digestive system carcinoma"
    }
  ]
}