{
  "id": 6920,
  "label": "atopic IgE-mediated allergic disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005202",
  "properties": {
    "xrefs": [
      "EFO:0002686",
      "ICD9:995.3",
      "MEDGEN:739536",
      "SCTID:115665000",
      "UMLS:C1706410"
    ],
    "synonyms": [
      "Atopic allergy",
      "atopic state",
      "atopy"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A genetic predisposition to form IgE antibodies in response to exposure to allergens and therefore, for the development of immediate (type I) hypersensitivity and atopic conditions, such as allergic rhinitis; bronchial asthma, atopic dermatitis, and food allergy. Mutations of specific alleles on the long arm of chromosome 5 have been associated with higher levels of IL-4 and IgE and are known as IL-4 promoter polymorphisms."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6969,
      "label": "allergic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3018
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1205",
          "ICD9:995.3",
          "ICD9:V15.09",
          "MEDGEN:9370",
          "MESH:D006967",
          "NCIT:C114476",
          "SCTID:609328004",
          "UMLS:C0020517"
        ],
        "synonyms": [
          "allergic disease or disorder",
          "allergic form of disease or disorder",
          "allergic form of immune system disease",
          "allergic reaction",
          "allergic response",
          "allergy",
          "disorder of type I hypersensitivity",
          "type I hypersensitivity disease",
          "allergic hypersensitivity disease",
          "hypersensitivity"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005271"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6969,
      "label": "allergic disease"
    }
  ]
}