{
  "id": 6923,
  "label": "renal carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005206",
  "properties": {
    "xrefs": [
      "DOID:4451",
      "EFO:0002890",
      "MEDGEN:235133",
      "NCIT:C9384",
      "UMLS:C1378703",
      "icd11.foundation:1075394530"
    ],
    "synonyms": [
      "kidney (including renal cell) cancer",
      "kidney (renal) cancer",
      "kidney cancer",
      "renal cancer",
      "carcinoma of kidney",
      "kidney carcinoma",
      "renal carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A carcinoma arising from the epithelium of the renal parenchyma or the renal pelvis. The majority are renal cell carcinomas. Kidney carcinomas usually affect middle aged and elderly adults. Hematuria, abdominal pain, and a palpable mass are common symptoms."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4465,
      "label": "kidney cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7836,
        20396
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:263",
          "ICD9:189.0",
          "MEDGEN:149263",
          "MESH:D007680",
          "NCIT:C7548",
          "SCTID:363518003",
          "UMLS:C0740457"
        ],
        "synonyms": [
          "cancer of kidney",
          "kidney cancer",
          "malignant kidney neoplasm",
          "malignant kidney tumor",
          "malignant kidney tumour",
          "malignant neoplasm of kidney",
          "malignant neoplasm of the kidney",
          "malignant renal neoplasm",
          "malignant renal tumor",
          "malignant renal tumour",
          "malignant tumor of kidney",
          "malignant tumor of the kidney",
          "malignant tumour of the kidney"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Primary or metastatic malignant neoplasm involving the kidney."
      },
      "child_count": 16,
      "reference_id": "MONDO:0002367"
    },
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 6508,
      "label": "kidney carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        6923
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9234",
          "ICD9:233.9",
          "MEDGEN:673070",
          "SCTID:92624000",
          "UMLS:C0686172"
        ],
        "synonyms": [
          "carcinoma in situ of kidney",
          "kidney in situ carcinoma",
          "stage 0 kidney carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma in situ involving a kidney."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004732"
    },
    {
      "id": 6814,
      "label": "renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        6923
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4450",
          "EFO:0000681",
          "GARD:0013215",
          "HP:0005584",
          "ICD9:189.0",
          "MEDGEN:766",
          "MESH:D002292",
          "MedDRA:10067946",
          "NANDO:2200045",
          "NORD:1657",
          "ONCOTREE:RCC",
          "Orphanet:217071",
          "SCTID:702391001",
          "UMLS:C0007134"
        ],
        "synonyms": [
          "RCC",
          "renal cell carcinoma",
          "renal cell carcinoma (disease)",
          "kidney adenocarcinoma",
          "renal cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the kidney"
      },
      "child_count": 22,
      "reference_id": "MONDO:0005086"
    },
    {
      "id": 7174,
      "label": "renal pelvis carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6923,
        23480
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4919",
          "EFO:0005582",
          "ICD10CM:C65",
          "ICD9:189.1",
          "MEDGEN:235548",
          "NCIT:C6142",
          "SCTID:363457009",
          "UMLS:C1335749"
        ],
        "synonyms": [
          "cancer of renal pelvis",
          "malignant neoplasm of renal pelvis",
          "malignant renal pelvis neoplasm",
          "malignant tumour of renal pelvis",
          "renal pelvis cancer",
          "carcinoma of kidney pelvis",
          "carcinoma of renal pelvis",
          "carcinoma of the kidney pelvis",
          "carcinoma of the renal pelvis",
          "kidney pelvis carcinoma",
          "kidney renal pelvis cancer",
          "renal pelvis carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A carcinoma arising in the renal pelvis. The majority of renal pelvis carcinomas are transitional cell and less frequently squamous cell carcinomas."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005519"
    }
  ],
  "roots": [
    {
      "id": 4465,
      "label": "kidney cancer"
    },
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}