{
  "id": 6928,
  "label": "rhabdomyosarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005212",
  "properties": {
    "xrefs": [
      "DOID:3247",
      "EFO:0002918",
      "GARD:0011951",
      "HP:0002859",
      "ICD9:171.9",
      "ICDO:8900/3",
      "MEDGEN:20561",
      "MESH:D012208",
      "MedDRA:10039022",
      "NANDO:2200056",
      "NCIT:C3359",
      "ONCOTREE:RMS",
      "Orphanet:780",
      "SCTID:302847003",
      "UMLS:C0035412"
    ],
    "synonyms": [
      "rhabdomyosarcoma",
      "rhabdomyosarcoma (disease)",
      "rhabdomyosarcoma, malignant"
    ],
    "definition": "A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. It usually occurs in children and young adults. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomical sites."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 20,
  "parents": [
    {
      "id": 18239,
      "label": "soft tissue sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6816,
        21548
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070663",
          "EFO:1001968",
          "GARD:0004898",
          "MEDGEN:1642116",
          "NCIT:C9306",
          "NORD:1953",
          "Orphanet:3394",
          "SCTID:424952003",
          "UMLS:C4551687"
        ],
        "synonyms": [
          "malignant soft tissue tumor",
          "malignant soft tissue tumour",
          "connective tissue sarcoma",
          "malignant mesenchymal tumor",
          "malignant mesenchymal tumour",
          "non-Rhabdo. soft tissue sarcoma",
          "sarcoma of soft tissue",
          "sarcoma of the soft tissue",
          "soft part sarcoma",
          "soft tissue sarcoma"
        ],
        "definition": "A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones."
      },
      "child_count": 92,
      "reference_id": "MONDO:0018078"
    }
  ],
  "children": [
    {
      "id": 4641,
      "label": "orbit rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6689,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3259",
          "GARD:0023174",
          "MEDGEN:83419",
          "MESH:C537605",
          "NCIT:C4543",
          "SCTID:254994000",
          "UMLS:C0346347"
        ],
        "synonyms": [
          "orbital region rhabdomyosarcoma",
          "orbital region rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma (disease) of orbital region",
          "rhabdomyosarcoma of orbit",
          "rhabdomyosarcoma of the orbit"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A malignant mesenchymal neoplasm with skeletal muscle differentiation that arises from the orbit."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002580"
    },
    {
      "id": 4642,
      "label": "spindle cell rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4933,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3260",
          "GARD:0023175",
          "ICD9:171.9",
          "ICDO:8912/3",
          "MEDGEN:224766",
          "NCIT:C6519",
          "ONCOTREE:SCRMS",
          "SCTID:404055006",
          "UMLS:C1266134"
        ],
        "synonyms": [
          "spindle cell rhabdomyosarcoma (morphologic abnormality)",
          "SCRMS"
        ],
        "definition": "An uncommon variant of rhabdomyosarcoma characterized by the presence of whorls of spindle cells forming a storiform pattern. In children it usually arises in the paratesticular region. In adults it usually arises from the deep soft tissues in the head and neck."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002581"
    },
    {
      "id": 4863,
      "label": "liver rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4487,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4047",
          "GARD:0023267",
          "MEDGEN:232598",
          "NCIT:C5834",
          "UMLS:C1333975"
        ],
        "synonyms": [
          "hepatic rhabdomyosarcoma",
          "liver rhabdomyosarcoma",
          "liver rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma (disease) of liver",
          "rhabdomyosarcoma of liver",
          "rhabdomyosarcoma of the liver"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant mesenchymal tumor with skeletal muscle differentiation affecting the liver."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002849"
    },
    {
      "id": 4864,
      "label": "central nervous system rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4336,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4048",
          "GARD:0023268",
          "MEDGEN:232043",
          "NCIT:C5464",
          "UMLS:C1332891"
        ],
        "synonyms": [
          "CNS rhabdomyosarcoma",
          "central nervous system rhabdomyosarcoma",
          "central nervous system rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma (disease) of central nervous system",
          "rhabdomyosarcoma of CNS",
          "rhabdomyosarcoma of central nervous system",
          "rhabdomyosarcoma of the CNS",
          "rhabdomyosarcoma of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant mesenchymal neoplasm with skeletal muscle differentiation affecting the central nervous system."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002850"
    },
    {
      "id": 4865,
      "label": "mediastinum rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4866,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4049",
          "GARD:0023269",
          "MEDGEN:233686",
          "NCIT:C6617",
          "UMLS:C1334677"
        ],
        "synonyms": [
          "mediastinal rhabdomyosarcoma",
          "mediastinum rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma (disease) of mediastinum",
          "rhabdomyosarcoma of mediastinum",
          "rhabdomyosarcoma of the mediastinum"
        ],
        "definition": "A malignant mesenchymal tumor with skeletal muscle differentiation affecting the mediastinum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002851"
    },
    {
      "id": 4867,
      "label": "rectum rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4294,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4053",
          "GARD:0023271",
          "MEDGEN:235532",
          "NCIT:C5627",
          "UMLS:C1335687"
        ],
        "synonyms": [
          "rectal rhabdomyosarcoma",
          "rectum rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma (disease) of rectum",
          "rhabdomyosarcoma of rectum",
          "rhabdomyosarcoma of the rectum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant mesenchymal tumor with skeletal muscle differentiation affecting the rectum."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002853"
    },
    {
      "id": 4870,
      "label": "gallbladder rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4871,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4057",
          "GARD:0023273",
          "MEDGEN:234294",
          "NCIT:C5839",
          "UMLS:C1333756"
        ],
        "synonyms": [
          "gall bladder rhabdomyosarcoma",
          "gall bladder rhabdomyosarcoma (disease)",
          "gallbladder rhabdomyosarcoma",
          "rhabdomyosarcoma (disease) of gall bladder",
          "rhabdomyosarcoma of gallbladder",
          "rhabdomyosarcoma of the gallbladder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A rhabdomyosarcoma that is located in the gallbladder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002856"
    },
    {
      "id": 4872,
      "label": "ovary rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4344,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4059",
          "GARD:0023275",
          "MEDGEN:233277",
          "NCIT:C5236",
          "UMLS:C1335176"
        ],
        "synonyms": [
          "ovarian rhabdomyosarcoma",
          "ovary rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma (disease) of ovary",
          "rhabdomyosarcoma of ovary",
          "rhabdomyosarcoma of the ovary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant mesenchymal tumor with skeletal muscle differentiation affecting the ovaries."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002858"
    },
    {
      "id": 4873,
      "label": "breast rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4569,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4060",
          "GARD:0023276",
          "MEDGEN:231970",
          "NCIT:C5190",
          "UMLS:C1332637"
        ],
        "synonyms": [
          "breast rhabdomyosarcoma",
          "breast rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma (disease) of breast",
          "rhabdomyosarcoma of breast",
          "rhabdomyosarcoma of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A malignant mesenchymal tumor with skeletal muscle differentiation affecting the breast."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002859"
    },
    {
      "id": 4874,
      "label": "testis rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4875,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4061",
          "GARD:0023277",
          "MEDGEN:234942",
          "NCIT:C6378",
          "UMLS:C1336726"
        ],
        "synonyms": [
          "rhabdomyosarcoma (disease) of testis",
          "rhabdomyosarcoma of testis",
          "rhabdomyosarcoma of the testis",
          "testicular rhabdomyosarcoma",
          "testis rhabdomyosarcoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant mesenchymal tumor with skeletal muscle differentiation affecting the testis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002860"
    },
    {
      "id": 4877,
      "label": "rhabdomyosarcoma with mixed embryonal and alveolar features",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4065",
          "GARD:0023280",
          "ICDO:8902/3",
          "MEDGEN:313444",
          "NCIT:C4259",
          "UMLS:C1709053"
        ],
        "synonyms": [
          "mixed alveolar rhabdomyosarcoma",
          "mixed type alveolar rhabdomyosarcoma",
          "rhabdomyosarcoma with mixed embryonal and alveolar features"
        ],
        "definition": "A rhabdomyosarcoma composed of embryonic and alveolar components. It is characterized by the presence of spindle cells with myoblastic differentiation, a myxoid stroma, and fibrous septa. These tumors were previously considered variants of alveolar rhabdomyosarcoma. The lack of PAX3-FOXO1 fusions in most of these tumors suggests that are biologically and clinically related to embryonal rhabdomyosarcoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002863"
    },
    {
      "id": 7909,
      "label": "prostate rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4868,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3252",
          "EFO:1000498",
          "GARD:0024394",
          "MEDGEN:233356",
          "NCIT:C5522",
          "UMLS:C1335518"
        ],
        "synonyms": [
          "prostate gland rhabdomyosarcoma",
          "prostate gland rhabdomyosarcoma (disease)",
          "prostate rhabdomyosarcoma",
          "rhabdomyosarcoma (disease) of prostate gland",
          "rhabdomyosarcoma of prostate",
          "rhabdomyosarcoma of the prostate"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant mesenchymal neoplasm with skeletal muscle differentiation affecting the prostate."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006389"
    },
    {
      "id": 11190,
      "label": "embryonal rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3246",
          "EFO:0000437",
          "GARD:0004702",
          "HP:0006743",
          "ICD9:171.9",
          "ICDO:8910/3",
          "MEDGEN:104910",
          "MedDRA:10065868",
          "NCIT:C8971",
          "OMIM:268210",
          "ONCOTREE:ERMS",
          "Orphanet:99757",
          "SCTID:404051002",
          "UMLS:C0206656"
        ],
        "synonyms": [
          "ERMS",
          "embryonal rhabdomyosarcoma",
          "embryonal rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma, embryonal, type 1",
          "rhabdomyosarcoma, somatic",
          "RMSE1",
          "botryoid rhabdomyosarcoma (type of ERMS)",
          "rhabdomyosarcoma 1",
          "rhabdomyosarcoma chromosomal region",
          "rhabdomyosarcoma embryonal",
          "rhabdomyosarcoma, embryonal, 1",
          "spindle cell rhabdomyosarcomas (type of ERMS)"
        ],
        "definition": "A poorly circumscribed morphologic variant of rhabdomyosarcoma. It is characterized by the presence of primitive skeletal muscle differentiation in any stage of myogenesis."
      },
      "child_count": 5,
      "reference_id": "MONDO:0009993"
    },
    {
      "id": 11191,
      "label": "alveolar rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4051",
          "EFO:0000248",
          "GARD:0004701",
          "HP:0006779",
          "ICD9:171.9",
          "ICDO:8920/3",
          "MEDGEN:61651",
          "MESH:D018232",
          "MedDRA:10065867",
          "NCIT:C3749",
          "OMIM:268220",
          "ONCOTREE:ARMS",
          "Orphanet:99756",
          "SCTID:404053004",
          "UMLS:C0206655",
          "icd11.foundation:1742058067"
        ],
        "synonyms": [
          "ARMS",
          "alveolar rhabdomyosarcoma",
          "alveolar rhabdomyosarcoma (disease)",
          "alveolar rhabdomyosarcoma (morphologic abnormality)",
          "arms",
          "monomorphous round cell rhabdomyosarcoma",
          "paediatric alveolar rhabdomyosarcoma",
          "pediatric alveolar rhabdomyosarcoma",
          "rhabdomyosarcoma 2, alveolar, somatic mutation",
          "rhabdomyosarcoma type 2",
          "rhabdomyosarcoma, alveolar, somatic mutation",
          "RMS2",
          "rhabdomyosarcoma 2",
          "rhabdomyosarcoma alveolar",
          "rhabdomyosarcoma, alveolar"
        ],
        "definition": "A rapidly growing malignant mesenchymal neoplasm. It is characterized by the presence of round cells with myoblastic differentiation and a fibrovascular stroma resembling an alveolar growth pattern. The tumor usually presents in the extremities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009994"
    },
    {
      "id": 16722,
      "label": "vaginal rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4273,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020348",
          "MEDGEN:925567",
          "NCIT:C128080",
          "Orphanet:206492",
          "SCTID:766759009",
          "UMLS:C4288035"
        ],
        "synonyms": [
          "rhabdomyosarcoma (disease) of vagina",
          "vagina rhabdomyosarcoma",
          "vagina rhabdomyosarcoma (disease)",
          "vaginal rhabdomyosarcoma",
          "vulvovaginal rhabdomyosarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant mesenchymal neoplasm with skeletal muscle differentiation arising from the vagina."
      },
      "child_count": 2,
      "reference_id": "MONDO:0016095"
    },
    {
      "id": 16825,
      "label": "uterine corpus rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6327,
        6926,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020475",
          "MEDGEN:925579",
          "NCIT:C127058",
          "Orphanet:213615",
          "UMLS:C4288047"
        ],
        "synonyms": [
          "body of uterus rhabdomyosarcoma",
          "body of uterus rhabdomyosarcoma (disease)",
          "rhabdomyosarcoma (disease) of body of uterus",
          "uterine corpus rhabdomyosarcoma",
          "rhabdomyosarcoma of the corpus uteri"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare malignant heterologous neoplasm with skeletal muscle differentiation arising from the uterine corpus. It usually manifests with vaginal bleeding. The prognosis is poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016260"
    },
    {
      "id": 16841,
      "label": "rhabdomyosarcoma of the cervix uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6928,
        16839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020494",
          "MEDGEN:927341",
          "NCIT:C128048",
          "ONCOTREE:CERMS",
          "Orphanet:213802",
          "SCTID:763408003",
          "UMLS:C4289809"
        ],
        "synonyms": [
          "cervical rhabdomyosarcoma",
          "rhabdomyosarcoma (disease) of uterine cervix",
          "uterine cervix rhabdomyosarcoma",
          "uterine cervix rhabdomyosarcoma (disease)",
          "CERMS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare malignant neoplasm with skeletal muscle differentiation arising from the cervix."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016282"
    },
    {
      "id": 17695,
      "label": "pleomorphic rhabdomyosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3250",
          "GARD:0021165",
          "ICD9:171.9",
          "MEDGEN:137770",
          "NCIT:C4258",
          "ONCOTREE:PLRMS",
          "Orphanet:293199",
          "SCTID:404054005",
          "UMLS:C0334480"
        ],
        "synonyms": [
          "pleomorphic rhabdomyosarcoma"
        ],
        "definition": "An aggressive malignant mesenchymal neoplasm with skeletal muscle differentiation, occurring in adults and rarely in children. The tumor is characterized by the presence of bizarre round, spindle, and polygonal cells. Clinical presentation includes a rapidly enlarging painful mass usually of the lower extremities."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017386"
    },
    {
      "id": 25208,
      "label": "oral rhabdomyosarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6928,
        7170
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080900",
          "GARD:0026607"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A rhabdomyosarcoma located in the oral cavity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850346"
    },
    {
      "id": 25276,
      "label": "rhabdomyosarcoma, embryonal, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6928
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026652",
          "MEDGEN:357232",
          "OMIM:180295",
          "UMLS:C1867234"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0859046"
    }
  ],
  "roots": [
    {
      "id": 18239,
      "label": "soft tissue sarcoma"
    }
  ]
}