{
  "id": 6929,
  "label": "uterine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005213",
  "properties": {
    "xrefs": [
      "EFO:0002919",
      "MEDGEN:755620",
      "SCTID:446022000",
      "UMLS:C2960452"
    ],
    "synonyms": [
      "carcinoma of uterus",
      "uterus carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A carcinoma involving a uterus."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4754,
      "label": "uterine cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3637,
        20520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:363",
          "ICD9:179",
          "MEDGEN:57791",
          "MESH:D014594",
          "NCIT:C3552",
          "SCTID:371973000",
          "UMLS:C0153567",
          "icd11.foundation:1551596364"
        ],
        "synonyms": [
          "neoplasm of uterus",
          "tumor of uterus",
          "tumour of uterus",
          "uterine tumor",
          "uterine tumour",
          "uterus neoplasm",
          "cancer of the uterus",
          "cancer of uterus",
          "malignant neoplasm of the uterus",
          "malignant neoplasm of uterus",
          "malignant tumor of the uterus",
          "malignant tumor of uterus",
          "malignant tumour of the uterus",
          "malignant tumour of uterus",
          "malignant uterine neoplasm",
          "malignant uterine tumor",
          "malignant uterine tumour",
          "malignant uterus neoplasm",
          "uterine cancer",
          "uterus cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Primary or metastatic malignant neoplasm involving the uterine corpus and/or the cervix."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002715"
    },
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 4530,
      "label": "endometrial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6929,
        13033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2871",
          "EFO:1001512",
          "HP:0012114",
          "MEDGEN:96903",
          "NCIT:C7558",
          "ONCOTREE:UCEC",
          "SCTID:254878006",
          "UMLS:C0476089",
          "icd11.foundation:1123821211"
        ],
        "synonyms": [
          "endometrial cancer",
          "carcinoma of endometrium",
          "carcinoma of the endometrium",
          "carcinoma, endometrial, malignant",
          "endometrial carcinoma",
          "endometrial carcinoma (disease)",
          "endometrium carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002447"
    },
    {
      "id": 6489,
      "label": "uterus carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6433,
        6929
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9108",
          "ICD9:233.2",
          "MEDGEN:673127",
          "SCTID:92788005",
          "UMLS:C0686237"
        ],
        "synonyms": [
          "carcinoma in situ of uterus",
          "stage 0 uterus carcinoma",
          "uterus in situ carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma in situ involving a uterus."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004710"
    },
    {
      "id": 6855,
      "label": "cervical carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4978,
        6929
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2893",
          "EFO:0001061",
          "MEDGEN:86222",
          "NCIT:C9039",
          "SCTID:285432005",
          "UMLS:C0302592",
          "icd11.foundation:1743710977"
        ],
        "synonyms": [
          "cancer of cervix",
          "cancer of the cervix",
          "cancer of the uterine cervix",
          "cancer of uterine cervix",
          "cervical cancer",
          "cervical cancer, NOS",
          "cervix cancer",
          "uterine cervix cancer",
          "carcinoma of cervix",
          "carcinoma of cervix uteri",
          "carcinoma of the cervix",
          "carcinoma of the cervix uteri",
          "carcinoma of the uterine cervix",
          "carcinoma of uterine cervix",
          "cervical carcinoma",
          "cervix carcinoma",
          "cervix uteri carcinoma",
          "uterine cervix carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005131"
    },
    {
      "id": 7751,
      "label": "endometrial serous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        6974,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5750",
          "EFO:1000238",
          "MEDGEN:1659908",
          "NCIT:C27838",
          "ONCOTREE:USC",
          "UMLS:C0854924",
          "icd11.foundation:225222541"
        ],
        "synonyms": [
          "uterine serous adenocarcinoma",
          "uterine serous carcinoma",
          "body of uterus serous adenocarcinoma",
          "endometrial serous adenocarcinoma",
          "serous endometrial adenocarcinoma",
          "uterine corpus serous adenocarcinoma",
          "uterine papillary serous carcinoma",
          "uterine serous papillary adenocarcinoma",
          "uterine serous carcinoma/uterine papillary serous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A high grade, aggressive adenocarcinoma arising from the endometrium. It is characterized by the presence of complex papillary patterns with cellular budding. Atypical mitoses, necrosis, and psammoma bodies may be present. It is classified as type II endometrial carcinoma and it is not associated with endometrial hyperplasia. It tends to invade deeply into the myometrium and spreads into the lymphatic vessels. Patients frequently present with spread of the tumor beyond the uterus at the time of diagnosis. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006196"
    },
    {
      "id": 16829,
      "label": "squamous cell carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6823,
        6929,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020479",
          "MEDGEN:1633992",
          "Orphanet:213716",
          "UMLS:C4707099"
        ],
        "synonyms": [
          "body of uterus squamous cell carcinoma",
          "endometrial squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016266"
    },
    {
      "id": 16830,
      "label": "undifferentiated carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7257,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020480",
          "ICD10CM:C54.9",
          "MEDGEN:1638762",
          "Orphanet:213721",
          "UMLS:C4707822"
        ],
        "synonyms": [
          "body of uterus undifferentiated carcinoma",
          "endometrial undifferentiated carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Undifferentiated carcinoma of the corpus uteri is a rare cancer of corpus uteri presenting as a large, polypoid, intraluminal mass with necrosis, composed of small to intermediate-size, relatively uniform, dyshesive cells displaying no differentiation. It usually presents with dysfunctional bleeding or vaginal discharge and, less often, abdominal pain. Association with Lynch syndrome was reported."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016267"
    },
    {
      "id": 16831,
      "label": "papillary carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7594,
        8000
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020481",
          "MEDGEN:1805139",
          "Orphanet:213726",
          "UMLS:C5679804"
        ],
        "synonyms": [
          "body of uterus papillary carcinoma",
          "endometrial capillary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A papillary carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016268"
    },
    {
      "id": 16834,
      "label": "adenoid cystic carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6713,
        6929,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:213741",
          "icd11.foundation:350868040"
        ],
        "synonyms": [
          "body of uterus adenoid cystic carcinoma",
          "endometrial adenoid cystic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A adenoid cystic carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016271"
    },
    {
      "id": 16835,
      "label": "transitional cell carcinoma of the corpus uteri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        7594,
        7972
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020484",
          "MEDGEN:1676303",
          "Orphanet:213746",
          "UMLS:C5191668"
        ],
        "synonyms": [
          "body of uterus transitional cell carcinoma",
          "endometrial transitional cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A transitional cell carcinoma that involves the body of uterus."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016272"
    }
  ],
  "roots": [
    {
      "id": 4754,
      "label": "uterine cancer"
    },
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}