{ "id": 6931, "label": "vulvar carcinoma", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0005215", "properties": { "xrefs": [ "DOID:1294", "EFO:0002921", "GARD:0009349", "MEDGEN:146159", "NCIT:C4866", "Orphanet:494418", "SCTID:447882007", "UMLS:C0677055" ], "synonyms": [ "cancer of the vulva", "cancer of vulva", "vulva cancer", "vulvar cancer", "carcinoma of mammalian vulva", "carcinoma of the vulva", "carcinoma of vulva", "mammalian vulva carcinoma", "vulva carcinoma", "vulvar carcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from epithelial cells of the mammalian vulva" }, "isLeaf": false, "isRoot": false, "child_count": 9, "parents": [ { "id": 3735, "label": "vulva cancer", "isLeaf": false, "isRoot": false, "parents": [ 3637, 20293 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1245", "GARD:0027581", "ICD10CM:C51", "ICD9:184.4", "MEDGEN:91196", "MESH:D014846", "NCIT:C7502", "SCTID:363367000", "UMLS:C0375071", "icd11.foundation:1530443809" ], "synonyms": [ "neoplasm of vulva", "vulval neoplasm", "vulvar tumour", "cancer of mammalian vulva", "malignant mammalian vulva neoplasm", "malignant neoplasm of mammalian vulva", "malignant neoplasm of the vulva", "malignant neoplasm of vulva", "malignant neoplasm of vulva unspecified", "malignant neoplasm of vulva, unspecified", "malignant tumor of the vulva", "malignant tumor of vulva", "malignant tumour of the vulva", "malignant tumour of vulva", "malignant vulva neoplasm", "malignant vulva tumor", "malignant vulva tumour", "malignant vulvar neoplasm", "malignant vulvar tumor", "malignant vulvar tumour", "mammalian vulva cancer", "vulval cancer", "vulvar cancer" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A primary or metastatic malignant neoplasm involving the vulva." }, "child_count": 16, "reference_id": "MONDO:0001528" }, { "id": 6734, "label": "carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 6733, 7265 ], "type_id": 0, "properties": { "xrefs": [ "CSP:2000-1867", "DOID:305", "EFO:0000313", "ICDO:8010/3", "ICDO:8011/3", "MEDGEN:2867", "MESH:D002277", "NCIT:C2916", "SCTID:722688002", "UMLS:C0007097" ], "synonyms": [ "epithelioma", "Other carcinoma", "carcinoma", "carcinoma, malignant", "epithelial carcinoma", "epithelioma malignant", "malignant epithelial neoplasm", "malignant epithelial tumor", "malignant epithelial tumour", "malignant epithelioma" ], "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas." }, "child_count": 98, "reference_id": "MONDO:0004993" } ], "children": [ { "id": 3800, "label": "labia minora carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 3733, 4707, 6931 ], "type_id": 0, "properties": { "xrefs": [ "DOID:1293", "GARD:0022971", "MEDGEN:233605", "NCIT:C9364", "UMLS:C1334357" ], "synonyms": [ "labia minora cancer", "carcinoma of labia minora", "carcinoma of labium minora", "carcinoma of the labia minora", "labia minora carcinoma", "labium minora carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from the labia minora." }, "child_count": 0, "reference_id": "MONDO:0001602" }, { "id": 3890, "label": "labia majora carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 3624, 4707, 6931 ], "type_id": 0, "properties": { "xrefs": [ "DOID:13389", "GARD:0022990", "MEDGEN:235247", "NCIT:C9363", "UMLS:C1334356" ], "synonyms": [ "carcinoma of labia majora", "carcinoma of labium majora", "carcinoma of the labia majora", "labia majora cancer", "labia majora carcinoma", "labium majora carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from the labia majora." }, "child_count": 0, "reference_id": "MONDO:0001702" }, { "id": 4848, "label": "bartholin gland carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 3053, 6931, 20353 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3999", "DOID:60003", "EFO:1000103", "GARD:0023257", "HP:0030419", "MEDGEN:83888", "NCIT:C9055", "SCTID:276876007", "UMLS:C0349561" ], "synonyms": [ "Bartholin gland cancer", "Bartholin gland carcinoma (disease)", "Bartholin's gland cancer", "Bartholin's gland carcinoma", "bartholin gland carcinoma", "carcinoma of Bartholin's gland", "carcinoma of major vestibular gland", "carcinoma of the Bartholin's gland", "major vestibular gland carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from the Bartholin gland. It usually affects women over fifty and presents with enlargement of the Bartholin gland. Various histologic subtypes have been identified and include adenocarcinoma, squamous cell carcinoma, adenoid cystic carcinoma, adenosquamous carcinoma, transitional cell carcinoma, and small cell carcinoma." }, "child_count": 12, "reference_id": "MONDO:0002829" }, { "id": 4960, "label": "vulva basal cell carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 6931, 7027 ], "type_id": 0, "properties": { "xrefs": [ "DOID:4301", "GARD:0022006", "MEDGEN:234481", "NCIT:C6381", "Orphanet:494451", "SCTID:717731002", "UMLS:C1336977", "icd11.foundation:247568702" ], "synonyms": [ "basal cell carcinoma of the vulva", "basal cell carcinoma of vulva", "mammalian vulva skin basal cell carcinoma", "skin basal cell carcinoma of mammalian vulva", "vulvar basal cell cancer", "vulvar basal cell carcinoma" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A slow growing, locally infiltrating carcinoma that arises from the vulva. It is characterized by the presence of malignant cells that resemble the basal cells that are present in the epidermis." }, "child_count": 0, "reference_id": "MONDO:0002955" }, { "id": 8097, "label": "vulvar seborrheic keratosis", "isLeaf": false, "isRoot": false, "parents": [ 4318, 4707, 6931, 9715 ], "type_id": 0, "properties": { "xrefs": [ "DOID:6944", "GARD:0024446", "MEDGEN:237055", "NCIT:C6375", "UMLS:C1336981" ], "synonyms": [ "mammalian vulva seborrheic keratosis", "seborrheic keratosis of mammalian vulva", "seborrheic keratosis of the vulva", "seborrheic keratosis of vulva" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A benign squamous neoplasm that arises from the vulva. It is characterized by the proliferation of the basal cells in the squamous epithelium, acanthosis, hyperkeratosis, and cysts formation." }, "child_count": 4, "reference_id": "MONDO:0006622" }, { "id": 21365, "label": "vulvar adenocarcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4321, 6712, 6931 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2098", "GARD:0022007", "MEDGEN:234480", "NCIT:C6380", "Orphanet:494454", "UMLS:C1336975" ], "synonyms": [ "adenocarcinoma of the vulva", "adenocarcinoma of vulva", "mammalian vulva adenocarcinoma", "vulva adenocarcinoma", "vulvar adenocarcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "An adenocarcinoma that arises from the vulva. Representative examples include Bartholin gland adenocarcinoma, eccrine adenocarcinoma, apocrine adenocarcinoma, and sebaceous carcinoma." }, "child_count": 21, "reference_id": "MONDO:0024336" }, { "id": 21524, "label": "vulvar squamous cell carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4318, 6823, 6931 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2101", "EFO:1000624", "GARD:0022005", "MEDGEN:79201", "NCIT:C4052", "Orphanet:494448", "SCTID:254895003", "UMLS:C0280856", "icd11.foundation:146824338" ], "synonyms": [ "epidermoid carcinoma of the vulva", "epidermoid carcinoma of vulva", "epidermoid cell carcinoma of the vulva", "epidermoid cell carcinoma of vulva", "mammalian vulva squamous cell carcinoma", "squamous cell carcinoma of the vulva", "squamous cell carcinoma of vulva", "vulva epidermoid carcinoma", "vulva epidermoid cell carcinoma", "vulva squamous cell carcinoma", "vulvar epidermoid carcinoma", "vulvar epidermoid cell carcinoma", "vulvar squamous cell cancer", "vulvar squamous cell carcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003)" }, "child_count": 18, "reference_id": "MONDO:0024609" }, { "id": 21599, "label": "clitoral carcinoma", "isLeaf": true, "isRoot": false, "parents": [ 4402, 6931 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025470", "MEDGEN:234155", "NCIT:C9362", "UMLS:C1333070" ], "synonyms": [ "clitoral cancer", "carcinoma of clitoris", "carcinoma of the clitoris", "clitoral carcinoma", "clitoris carcinoma" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" } ], "definition": "A carcinoma that arises from the clitoris." }, "child_count": 0, "reference_id": "MONDO:0024873" }, { "id": 23671, "label": "vulvar neuroendocrine carcinoma", "isLeaf": false, "isRoot": false, "parents": [ 4255, 6931 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025992", "MEDGEN:925534", "NCIT:C128243", "UMLS:C4288002" ], "synonyms": [ "mammalian vulva neuroendocrine carcinoma", "neuroendocrine carcinoma of mammalian vulva", "vulvar Neuroendocrine cancer", "vulvar Neuroendocrine carcinoma", "vulvar high grade Neuroendocrine carcinoma", "vulvar high grade Neuroendocrine neoplasm" ], "categories": [ { "ref": "MONDO:0005039", "name": "reproductive system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "A neuroendocrine carcinoma that arises from the vulva. This category includes small cell and large cell neuroendocrine carcinoma. Most small cell neuroendocrine carcinomas of the vulva are Merkel cell carcinomas." }, "child_count": 2, "reference_id": "MONDO:0056816" } ], "roots": [ { "id": 3735, "label": "vulva cancer" }, { "id": 6734, "label": "carcinoma" } ] }