{
  "id": 6943,
  "label": "large cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005232",
  "properties": {
    "xrefs": [
      "DOID:4552",
      "ICDO:8012/3",
      "MEDGEN:61665",
      "MESH:D018287",
      "NCIT:C3780",
      "UMLS:C0206704"
    ],
    "synonyms": [
      "carcinoma, large cell",
      "large cell carcinoma"
    ],
    "definition": "A malignant epithelial neoplasm composed of large, atypical cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 5040,
      "label": "lung large cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6943,
        6944
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4556",
          "EFO:0003050",
          "ICD9:162.9",
          "MEDGEN:91060",
          "NCIT:C4450",
          "ONCOTREE:LCLC",
          "SCTID:254629004",
          "UMLS:C0345958"
        ],
        "synonyms": [
          "anaplastic lung carcinoma",
          "large cell carcinoma of lung",
          "large cell carcinoma of the lung",
          "large cell lung cancer",
          "large cell lung carcinoma",
          "large cell undifferentiated lung carcinoma",
          "lung large cell carcinoma",
          "LCLC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection."
      },
      "child_count": 14,
      "reference_id": "MONDO:0003050"
    },
    {
      "id": 5471,
      "label": "nasopharyngeal type undifferentiated carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6943
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5660",
          "ICDO:8082/3",
          "MEDGEN:87199",
          "NCIT:C4107",
          "UMLS:C0334254"
        ],
        "synonyms": [
          "Schmincke tumor",
          "Schmincke tumour",
          "Schminke tumor",
          "Schminke tumour",
          "lymphoepithelial carcinoma",
          "lymphoepithelioma",
          "lymphoepithelioma-like carcinoma",
          "nasopharyngeal type undifferentiated carcinoma"
        ],
        "definition": "A nonkeratinizing carcinoma which occurs predominantly in the nasopharynx but also in the tonsils and rarely in other anatomic sites. It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003572"
    },
    {
      "id": 6787,
      "label": "large cell neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        6943
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050872",
          "EFO:0000563",
          "GARD:0024145",
          "ICDO:8013/3",
          "MEDGEN:220402",
          "NCIT:C6875",
          "ONCOTREE:LUNE",
          "UMLS:C1265996",
          "icd11.foundation:1278312485"
        ],
        "synonyms": [
          "LCNEC",
          "large cell NEC",
          "large cell neuroendocrine carcinoma",
          "large-cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005057"
    },
    {
      "id": 7923,
      "label": "salivary gland large cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2972,
        6943,
        7257
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000517",
          "GARD:0027753",
          "MEDGEN:810975",
          "NCIT:C35735",
          "UMLS:C2111671"
        ],
        "synonyms": [
          "large cell salivary gland carcinoma",
          "large cell undifferentiated salivary gland carcinoma",
          "saliva-secreting gland large cell carcinoma",
          "salivary gland large cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A rare, highly aggressive carcinoma that arises from the salivary gland, predominantly the parotid gland. It is characterized by the presence of large pleomorphic malignant cells with abundant cytoplasm. Patients usually present with a rapidly growing mass."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006404"
    },
    {
      "id": 7968,
      "label": "thyroid gland undifferentiated (anaplastic) carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6943,
        7257,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080522",
          "EFO:1000595",
          "GARD:0000664",
          "HP:0011779",
          "MEDGEN:116064",
          "MESH:D065646",
          "MedDRA:10002240",
          "NCIT:C3878",
          "ONCOTREE:THAP",
          "Orphanet:142",
          "SCTID:255031003",
          "UMLS:C0238461",
          "icd11.foundation:320540024"
        ],
        "synonyms": [
          "Dedifferentiated thyroid gland carcinoma",
          "anaplastic carcinoma of the thyroid",
          "anaplastic carcinoma of the thyroid gland",
          "anaplastic carcinoma of thyroid",
          "anaplastic carcinoma of thyroid gland",
          "anaplastic thyroid cancer",
          "anaplastic thyroid carcinoma",
          "anaplastic thyroid gland carcinoma",
          "metaplastic thyroid gland carcinoma",
          "pleomorphic thyroid gland carcinoma",
          "sarcomatoid thyroid gland carcinoma",
          "thyroid gland carcinosarcoma",
          "thyroid gland undifferentiated (anaplastic) carcinoma",
          "thyroid gland undifferentiated carcinoma",
          "undifferentiated (anaplastic) thyroid gland cancer",
          "undifferentiated (anaplastic) thyroid gland carcinoma",
          "undifferentiated carcinoma of the thyroid",
          "undifferentiated carcinoma of the thyroid gland",
          "undifferentiated carcinoma of thyroid",
          "undifferentiated carcinoma of thyroid gland",
          "undifferentiated thyroid carcinoma",
          "undifferentiated thyroid gland carcinoma",
          "undifferentiated thyroid tumor",
          "undifferentiated thyroid tumour",
          "THAP",
          "thyroid cancer, anaplastic",
          "thyroid carcinoma, anaplastic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006468"
    }
  ],
  "roots": [
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}