{
  "id": 6969,
  "label": "allergic disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005271",
  "properties": {
    "xrefs": [
      "DOID:1205",
      "ICD9:995.3",
      "ICD9:V15.09",
      "MEDGEN:9370",
      "MESH:D006967",
      "NCIT:C114476",
      "SCTID:609328004",
      "UMLS:C0020517"
    ],
    "synonyms": [
      "allergic disease or disorder",
      "allergic form of disease or disorder",
      "allergic form of immune system disease",
      "allergic reaction",
      "allergic response",
      "allergy",
      "disorder of type I hypersensitivity",
      "type I hypersensitivity disease",
      "allergic hypersensitivity disease",
      "hypersensitivity"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060056",
          "EFO:1002003",
          "MEDGEN:759636",
          "NCIT:C3114",
          "SCTID:473010000",
          "UMLS:C3532523"
        ],
        "synonyms": [
          "allergic reaction",
          "sensitive",
          "sensitivity",
          "hypersensitive",
          "hypersensitivity",
          "hypersensitivity reaction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000605"
    }
  ],
  "children": [
    {
      "id": 3133,
      "label": "allergic respiratory disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6815,
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060496",
          "MEDGEN:734246",
          "UMLS:C1504369"
        ],
        "synonyms": [
          "allergic form of respiratory system disease",
          "allergic respiratory system disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A respiratory system disease with a basis in a pathological type I hypersensitivity reaction."
      },
      "child_count": 8,
      "reference_id": "MONDO:0000771"
    },
    {
      "id": 3135,
      "label": "drug allergy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060500",
          "EFO:0009482",
          "MEDGEN:41663",
          "MESH:D004342",
          "UMLS:C0013182"
        ],
        "synonyms": [
          "allergy of exposure to drug",
          "exposure to drug allergic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Immunologically mediated adverse reactions to medicinal substances used legally or illegally."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000775"
    },
    {
      "id": 3136,
      "label": "gastrointestinal allergy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060502",
          "MEDGEN:1843477",
          "UMLS:C0221034"
        ],
        "synonyms": [
          "allergic disease of digestive tract",
          "digestive tract allergic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A allergic disease that involves the digestive tract."
      },
      "child_count": 1,
      "reference_id": "MONDO:0000777"
    },
    {
      "id": 3137,
      "label": "latex allergy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060532",
          "ICD9:989.82",
          "ICD9:995.3",
          "ICD9:V15.07",
          "MEDGEN:107909",
          "MESH:D020315",
          "SCTID:300916003",
          "UMLS:C0577628"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (hypersensitivity, delayed) and IgE antibody-mediated (hypersensitivity, immediate) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000807"
    },
    {
      "id": 6721,
      "label": "atopic eczema",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4496,
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3310",
          "EFO:0000274",
          "HP:0001047",
          "ICD10CM:L20",
          "ICD9:691",
          "ICD9:691.8",
          "MEDGEN:41502",
          "MESH:D003876",
          "NCIT:C3001",
          "OMIM:603165",
          "SCTID:200775004",
          "SCTID:24079001",
          "UMLS:C0011615",
          "icd11.foundation:215767047"
        ],
        "synonyms": [
          "ATOD",
          "allergic form of dermatitis",
          "atopic dermatitis",
          "atopic eczema",
          "dermatitis, atopic",
          "eczema",
          "eczema, atopic",
          "eczematous dermatitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A common chronic pruritic inflammatory skin disease with a strong genetic component. Onset typically occurs during the first 2 years of life."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004980"
    },
    {
      "id": 6920,
      "label": "atopic IgE-mediated allergic disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0002686",
          "ICD9:995.3",
          "MEDGEN:739536",
          "SCTID:115665000",
          "UMLS:C1706410"
        ],
        "synonyms": [
          "Atopic allergy",
          "atopic state",
          "atopy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A genetic predisposition to form IgE antibodies in response to exposure to allergens and therefore, for the development of immediate (type I) hypersensitivity and atopic conditions, such as allergic rhinitis; bronchial asthma, atopic dermatitis, and food allergy. Mutations of specific alleles on the long arm of chromosome 5 have been associated with higher levels of IL-4 and IgE and are known as IL-4 promoter polymorphisms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005202"
    },
    {
      "id": 7201,
      "label": "eye allergy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6969,
        7019
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005751",
          "MEDGEN:1843485",
          "UMLS:C0852875"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "An allergic disease involving a pathogenic inflammatory response in the camera-type eye."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005551"
    },
    {
      "id": 9946,
      "label": "vulvovaginitis, allergic seminal",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6969,
        8440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:348089",
          "MESH:C565993",
          "OMIM:193450",
          "UMLS:C1860357"
        ],
        "synonyms": [
          "vulvovaginitis, allergic seminal"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008669"
    },
    {
      "id": 20420,
      "label": "allergic otitis media",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6969,
        7108
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:543352",
          "SCTID:26169004",
          "UMLS:C0271447"
        ],
        "synonyms": [
          "allergic form of otitis media (disease)",
          "allergic otitis media (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A otitis media (disease) with a basis in a pathological type I hypersensitivity reaction."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021202"
    },
    {
      "id": 23761,
      "label": "alpha-gal syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070659",
          "MEDGEN:1778444",
          "UMLS:C5442181"
        ],
        "synonyms": [
          "AGS",
          "allergic galactose-alpha-1,3-galactose disease",
          "alpha-gal allergy",
          "red meat allergy",
          "tick bite meat allergy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An IgE antibody response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100001"
    },
    {
      "id": 24381,
      "label": "venom allergy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1387536",
          "UMLS:C4510560"
        ],
        "synonyms": [
          "IgE-mediated venom hypersensitivity",
          "venom hypersensitivity"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An allergic disease involving venom."
      },
      "child_count": 0,
      "reference_id": "MONDO:0600005"
    },
    {
      "id": 24621,
      "label": "food allergy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6969
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3044",
          "EFO:1001890",
          "ICD9:995.3",
          "MEDGEN:1635115",
          "MESH:D005512",
          "SCTID:414285001",
          "UMLS:C4554344"
        ],
        "synonyms": [
          "allergic disease from food material",
          "allergy of food material",
          "food material allergic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700226"
    }
  ],
  "roots": [
    {
      "id": 3018,
      "label": "hypersensitivity reaction disease"
    }
  ]
}