{
  "id": 6974,
  "label": "serous adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005278",
  "properties": {
    "xrefs": [
      "DOID:3114",
      "EFO:0003825",
      "NCIT:C40101"
    ],
    "synonyms": [
      "serous adenocarcinoma",
      "serous carcinoma",
      "serous cystadenocarcinoma",
      "serous cystadenocarcinoma, NOS (morphologic abnormality)"
    ],
    "definition": "An adenocarcinoma that is characterized by the presence of papillary patterns and cellular budding. Psammoma bodies may be present. Representative examples include cervical serous adenocarcinoma, endometrial serous adenocarcinoma, ovarian serous adenocarcinoma, and primary peritoneal serous adenocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    }
  ],
  "children": [
    {
      "id": 5154,
      "label": "peritoneal serous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4249,
        6974
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4901"
        ],
        "synonyms": [
          "peritoneum serous adenocarcinoma",
          "primary peritoneal serous adenocarcinoma"
        ],
        "definition": "A rare, serous adenocarcinoma that arises from the lining of the peritoneum. It affects females. The clinical behavior and pathologic characteristics are similar to the serous adenocarcinoma that arises from the ovary."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003195"
    },
    {
      "id": 5520,
      "label": "cervical serous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6877,
        6974
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5752",
          "GARD:0023593",
          "MEDGEN:308950",
          "NCIT:C40201",
          "UMLS:C1516431"
        ],
        "synonyms": [
          "cervical serous adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare adenocarcinoma that arises from the cervix. It is characterized by the presence of papillary patterns and cellular budding. Psammoma bodies are often seen."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003631"
    },
    {
      "id": 6927,
      "label": "ovarian serous adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4787,
        6974,
        21609
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050933",
          "DOID:5744",
          "EFO:0002917",
          "GARD:0024164",
          "MEDGEN:233278",
          "NCIT:C7550",
          "ONCOTREE:SOC",
          "UMLS:C1335177"
        ],
        "synonyms": [
          "ovarian serous adenocarcinoma",
          "ovarian serous carcinoma",
          "ovary serous adenocarcinoma",
          "serous adenocarcinoma of ovary",
          "serous adenocarcinoma of the ovary",
          "serous carcinoma of ovary",
          "serous carcinoma of the ovary",
          "malignant ovarian serous tumour",
          "serous ovarian cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia."
      },
      "child_count": 9,
      "reference_id": "MONDO:0005211"
    },
    {
      "id": 7751,
      "label": "endometrial serous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6929,
        6974,
        7594
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5750",
          "EFO:1000238",
          "MEDGEN:1659908",
          "NCIT:C27838",
          "ONCOTREE:USC",
          "UMLS:C0854924",
          "icd11.foundation:225222541"
        ],
        "synonyms": [
          "uterine serous adenocarcinoma",
          "uterine serous carcinoma",
          "body of uterus serous adenocarcinoma",
          "endometrial serous adenocarcinoma",
          "serous endometrial adenocarcinoma",
          "uterine corpus serous adenocarcinoma",
          "uterine papillary serous carcinoma",
          "uterine serous papillary adenocarcinoma",
          "uterine serous carcinoma/uterine papillary serous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A high grade, aggressive adenocarcinoma arising from the endometrium. It is characterized by the presence of complex papillary patterns with cellular budding. Atypical mitoses, necrosis, and psammoma bodies may be present. It is classified as type II endometrial carcinoma and it is not associated with endometrial hyperplasia. It tends to invade deeply into the myometrium and spreads into the lymphatic vessels. Patients frequently present with spread of the tumor beyond the uterus at the time of diagnosis. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006196"
    },
    {
      "id": 7761,
      "label": "fallopian tube serous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4781,
        6974
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5598",
          "EFO:1000253",
          "GARD:0024331",
          "MEDGEN:274490",
          "NCIT:C40099",
          "UMLS:C1517124"
        ],
        "synonyms": [
          "fallopian tube serous adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A serous adenocarcinoma that arises from the fallopian tube. It is usually a high grade invasive adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006208"
    },
    {
      "id": 21536,
      "label": "serous cystadenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6974,
        7240
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8441/3",
          "MEDGEN:60212",
          "NCIT:C3778",
          "UMLS:C0206701"
        ],
        "synonyms": [
          "serous adenocarcinoma",
          "serous cystadenocarcinoma"
        ],
        "definition": "A malignant serous cystic neoplasm usually involving the ovary or the pancreas. It is characterized by the presence of invasive malignant glandular epithelial cells which often form papillary structures."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024621"
    }
  ],
  "roots": [
    {
      "id": 6712,
      "label": "adenocarcinoma"
    }
  ]
}