{
  "id": 6980,
  "label": "chronic progressive multiple sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005284",
  "properties": {
    "xrefs": [
      "EFO:0003840",
      "MEDGEN:140733",
      "MESH:D020528",
      "SCTID:230373008",
      "UMLS:C0393665"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6995,
      "label": "multiple sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2996,
        7209,
        8166,
        20199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2377",
          "ICD10CM:G35",
          "ICD10WHO:G35",
          "ICD9:340",
          "MEDGEN:10123",
          "MESH:D009103",
          "NANDO:1200023",
          "NANDO:2100250",
          "NANDO:2200904",
          "NCIT:C3243",
          "Orphanet:802",
          "SCTID:24700007",
          "UMLS:C0026769",
          "icd11.foundation:1298865187"
        ],
        "synonyms": [
          "generalised multiple sclerosis",
          "generalized multiple sclerosis",
          "insular sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005301"
    }
  ],
  "children": [
    {
      "id": 2913,
      "label": "secondary progressive multiple sclerosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6980
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050783",
          "EFO:0008522",
          "MEDGEN:155969",
          "NANDO:1200026",
          "NANDO:2201321",
          "SCTID:425500002",
          "UMLS:C0751965",
          "icd11.foundation:1045965709"
        ],
        "synonyms": [
          "SPMS",
          "secondary-progressive MS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A multiple sclerosis with a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing-remitting (RR) phase."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000450"
    },
    {
      "id": 2914,
      "label": "primary progressive multiple sclerosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6980
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050784",
          "EFO:0008520",
          "MEDGEN:155968",
          "NANDO:1200025",
          "NANDO:2201320",
          "SCTID:428700003",
          "UMLS:C0751964",
          "icd11.foundation:1020720762"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. The rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000451"
    },
    {
      "id": 2915,
      "label": "progressive relapsing multiple sclerosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6980
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050785",
          "MEDGEN:95982",
          "SCTID:230374002",
          "UMLS:C0393666"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A multiple sclerosis that is characterized by steadily worsening symptoms and attacks during periods of remission with disease progression from the onset."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000452"
    }
  ],
  "roots": [
    {
      "id": 6995,
      "label": "multiple sclerosis"
    }
  ]
}