{
  "id": 6988,
  "label": "peripheral vascular disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005294",
  "properties": {
    "xrefs": [
      "DOID:341",
      "EFO:0003875",
      "ICD9:443.81",
      "MEDGEN:38790",
      "MESH:D016491",
      "NCIT:C35136",
      "UMLS:C0085096",
      "icd11.foundation:426429380"
    ],
    "synonyms": [
      "disease, peripheral vascular",
      "peripheral vascular disorder",
      "vascular disease, peripheral"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Any disorder affecting blood flow through the veins or arteries outside of the heart."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    }
  ],
  "children": [
    {
      "id": 3229,
      "label": "diabetic peripheral angiopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6988
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10182",
          "DOID:11713",
          "EFO:1000896",
          "ICD9:250.7",
          "ICD9:443.81",
          "MEDGEN:507633",
          "MESH:D003925",
          "NCIT:C35610",
          "SCTID:127014009",
          "UMLS:C0011871"
        ],
        "synonyms": [
          "diabetic angiopathy",
          "diabetic vascular disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Diabetic angiopathy is a form of angiopathy associated with diabetic complications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000960"
    },
    {
      "id": 3779,
      "label": "telangiectasis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6988,
        20710
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1272",
          "MEDGEN:21088",
          "MESH:D013684",
          "NCIT:C28194",
          "SCTID:247479008",
          "UMLS:C0039446"
        ],
        "synonyms": [
          "telangiectasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001576"
    },
    {
      "id": 6516,
      "label": "priapism",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6988,
        7045
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9286",
          "GARD:0019933",
          "ICD10CM:N48.3",
          "ICD9:607.3",
          "MEDGEN:19462",
          "MESH:D011317",
          "Orphanet:140949",
          "SCTID:6273006",
          "UMLS:C0033117",
          "icd11.foundation:1983776037"
        ],
        "synonyms": [
          "mentulagra",
          "low-flow priapism"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Persistent and usually painful erection that lasts for at least four hours in the absence of physical or psychological stimulation, which can be caused by hematologic disorders, including sickle cell disease and leukemia, spinal cord injuries, and medications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004745"
    },
    {
      "id": 6989,
      "label": "intermittent vascular claudication",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4391,
        6988
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3669",
          "EFO:0003876",
          "ICD9:440.21",
          "MEDGEN:7115",
          "MESH:D007383",
          "SCTID:63491006",
          "UMLS:C0021775"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A symptom complex characterized by pain and weakness in skeletal muscle group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial stenosis; muscle ischemia; and accumulation of lactate."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005295"
    },
    {
      "id": 7066,
      "label": "peripheral arterial disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2933,
        6988
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050830",
          "EFO:0004265",
          "ICD9:443.81",
          "MEDGEN:352846",
          "MESH:D058729",
          "NCIT:C84496",
          "SCTID:399957001",
          "UMLS:C1704436",
          "icd11.foundation:1821859817"
        ],
        "synonyms": [
          "PAD",
          "pad",
          "peripheral arterial disorder",
          "peripheral artery disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005386"
    },
    {
      "id": 8298,
      "label": "mesenteric vascular occlusion",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6988
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13252",
          "EFO:1001043",
          "MEDGEN:9972",
          "MESH:D008641",
          "MedDRA:10074583",
          "UMLS:C0025472"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Obstruction of the flow in the splanchnic circulation by atherosclerosis; embolism; thrombosis; stenosis; trauma; and compression or intrinsic pressure from adjacent tumors. Rare causes are drugs, intestinal parasites, and vascular immunoinflammatory diseases such as periarteritis nodosa and thromboangiitis obliterans. (From Juergens et al., Peripheral Vascular Diseases, 5th ed, pp295-6)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0006855"
    },
    {
      "id": 9664,
      "label": "Raynaud disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5714,
        6988
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10300",
          "EFO:1001145",
          "ICD10CM:I73.0",
          "ICD9:443.0",
          "MEDGEN:20473",
          "MESH:D011928",
          "NCIT:C116359",
          "OMIM:179600",
          "SCTID:195295006",
          "UMLS:C0034734"
        ],
        "synonyms": [
          "Raynaud disease",
          "Raynaud syndrome",
          "Raynaud's disease",
          "Raynaud's syndrome",
          "Raynaud's syndrome (disorder) [ambiguous]",
          "secondary Raynaud disease",
          "secondary Raynaud phenomenon",
          "secondary Raynaud's disease",
          "secondary Raynaud's phenomenon",
          "cold fingers, hereditary"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "An episodic vasoconstriction resulting in discoloration of the skin and pain in the affected areas, often involving fingers or toes. Classically associated with triphasic color changes (white, blue, red) but may be biphasic. Often occurs in response to cold temperatures or emotional stress. May be primary or secondary to an underlying autoimmune disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008364"
    },
    {
      "id": 10154,
      "label": "thromboangiitis obliterans",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6988,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12918",
          "EFO:1001211",
          "GARD:0005969",
          "ICD10CM:I73.1",
          "ICD9:443.1",
          "MEDGEN:21531",
          "MESH:D013919",
          "MedDRA:10043540",
          "NANDO:1200266",
          "NCIT:C35070",
          "NORD:880",
          "OMIM:211480",
          "Orphanet:36258",
          "SCTID:52403007",
          "UMLS:C0040021",
          "icd11.foundation:1000683110"
        ],
        "synonyms": [
          "Buerger's Disease",
          "Buerger's disease",
          "thromboangiitis obliterans",
          "thromboangiitis obliterans [Buerger's disease]",
          "BUERGER disease",
          "TAO",
          "inflammatory occlusive peripheral vascular disease",
          "occlusive peripheral vascular disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008889"
    },
    {
      "id": 16666,
      "label": "erythromelalgia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6988
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9240",
          "ICD10CM:I73.81",
          "ICD9:443.82",
          "MEDGEN:8687",
          "MESH:D004916",
          "MedDRA:10015284",
          "NCIT:C34593",
          "Orphanet:1956",
          "SCTID:37151006",
          "UMLS:C0014804",
          "icd11.foundation:838760425"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A rare neurovascular peripheral pain disorder due to the intermittent blockage of the blood vessels, usually in the lower extremities or hands. This causes hyperemia and inflammation at the origin of burning pain and skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia may occur either as a primary or secondary disorder. Primary erythromelalgia is caused by gene mutations. Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, essential thrombocytemia, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders."
      },
      "child_count": 4,
      "reference_id": "MONDO:0016028"
    },
    {
      "id": 23203,
      "label": "May-Thurner syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6988
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027061",
          "MEDGEN:473753",
          "MESH:D062108",
          "Orphanet:675404",
          "SCTID:448804008",
          "UMLS:C3165062"
        ],
        "synonyms": [
          "May-Thurner syndrome",
          "iliac vein compression syndrome",
          "Cockett syndrome",
          "Iliac vein compression syndrome",
          "Iliocaval compression syndrome",
          "Iliocaval compression syndromes",
          "May Thurner syndrome",
          "compression syndrome, Iliocaval",
          "compression syndromes, Iliocaval",
          "syndrome, Cockett",
          "syndrome, Iliocaval compression",
          "syndrome, May-Thurner",
          "syndromes, Iliocaval compression"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A compression of ILIAC VEIN that results in a decreased flow in the vein and in the left LOWER EXTREMITY due to a vascular malformation. It may result in left leg EDEMA, pain, iliofemoral DEEP VENOUS THROMBOSIS and POSTTHROMBOTIC SYNDROME. Compression of the left common ILIAC VEIN by the right common ILIAC ARTERY against the underlying fifth LUMBAR VERTEBRA is the typical underlying malformation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043361"
    },
    {
      "id": 23276,
      "label": "livedo reticularis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6988,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025876",
          "MEDGEN:43223",
          "MESH:D054068",
          "SCTID:238772004",
          "UMLS:C0085642"
        ],
        "synonyms": [
          "livedo reticularis",
          "livedo racemosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A condition characterized by a reticular or fishnet pattern on the skin of lower extremities and other parts of the body. This red and blue pattern is due to deoxygenated blood in unstable dermal blood vessels. The condition is intensified by cold exposure and relieved by rewarming."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044037"
    }
  ],
  "roots": [
    {
      "id": 7065,
      "label": "vascular disorder"
    }
  ]
}