{
  "id": 6990,
  "label": "sleep apnea syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005296",
  "properties": {
    "xrefs": [
      "DOID:0050847",
      "EFO:0003877",
      "HP:0010535",
      "ICD10CM:G47.3",
      "ICD9:780.57",
      "MEDGEN:11458",
      "MESH:D012891",
      "NCIT:C148023",
      "SCTID:111489007",
      "SCTID:73430006",
      "UMLS:C0037315"
    ],
    "synonyms": [
      "breathing-related sleep disorder",
      "SDB",
      "sleep apnea",
      "sleep apnea syndrome",
      "sleep apneas",
      "sleep disordered breathing",
      "sleep-disordered breathing",
      "apnea syndrome, sleep",
      "apnea syndromes, sleep",
      "apnea, sleep",
      "apneas, sleep",
      "breathing, sleep-disordered",
      "hypersomnia with periodic respiration",
      "hypopnea, sleep",
      "hypopneas, sleep",
      "mixed central and obstructive sleep apnea",
      "mixed sleep Apneas",
      "mixed sleep apnea",
      "sleep apnea, mixed",
      "sleep apnea, mixed central and obstructive",
      "sleep apneas, mixed",
      "sleep hypopnea",
      "sleep hypopneas"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A disorder characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5338,
      "label": "sleep-wake disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23833
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:535",
          "ICD10CM:G47",
          "ICD9:307.4",
          "ICD9:307.40",
          "ICD9:307.49",
          "MEDGEN:875755",
          "MESH:D012893",
          "SCTID:39898005",
          "UMLS:C4042891"
        ],
        "synonyms": [
          "disorder of sleep-wake cycle",
          "sleep wake disorder",
          "Subwakefullness syndrome",
          "Subwakefullness syndromes",
          "Tachypneas, sleep-related neurogenic",
          "disorder of sleep-wake schedule",
          "disorder, sleep",
          "disorder, sleep wake",
          "disorders of the sleep-wake schedule",
          "disorders, sleep",
          "disorders, sleep wake",
          "long sleeper syndrome",
          "long sleeper syndromes",
          "neurogenic Tachypneas, sleep-related",
          "neurogenic tachypnea, sleep-related",
          "non-organic sleep disorder",
          "phenotype, short sleep",
          "phenotypes, short sleep",
          "short sleep phenotype",
          "short sleep phenotypes",
          "short sleeper syndrome",
          "short sleeper syndromes",
          "sleep disorder",
          "sleep disorders",
          "sleep phenotypes, short",
          "sleep related neurogenic tachypnea",
          "sleep-related neurogenic Tachypneas",
          "sleep-related neurogenic tachypnea",
          "sleeper syndrome, long",
          "sleeper syndrome, short",
          "sleeper syndromes, long",
          "sleeper syndromes, short",
          "syndrome, Subwakefullness",
          "syndrome, long sleeper",
          "syndrome, short sleeper",
          "syndromes, Subwakefullness",
          "syndromes, long sleeper",
          "syndromes, short sleeper",
          "tachypnea, sleep-related neurogenic",
          "wake disorder, sleep",
          "wake disorders, sleep"
        ],
        "definition": "Abnormal sleep-wake schedule or pattern associated with the circadian rhythm which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle. These can include dyssomnias such as circadian rhythm disorders, hypersomnia, and sleep apnea and parasomnias such as bruxism and rapid eye movement sleep disorder."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003406"
    },
    {
      "id": 6815,
      "label": "respiratory system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1579",
          "EFO:0000684",
          "ICD10CM:J00-J99",
          "ICD9:460-519",
          "ICD9:500-508",
          "ICD9:503",
          "ICD9:508",
          "ICD9:508.1",
          "ICD9:508.8",
          "ICD9:508.9",
          "ICD9:510-519",
          "ICD9:516",
          "ICD9:516.8",
          "ICD9:516.9",
          "ICD9:517",
          "ICD9:517.8",
          "ICD9:519",
          "ICD9:519.1",
          "ICD9:519.3",
          "ICD9:519.8",
          "ICD9:519.9",
          "ICD9:V12.60",
          "ICD9:V47.2",
          "MEDGEN:48421",
          "MESH:D012140",
          "NANDO:1100010",
          "NCIT:C26871",
          "SCTID:50043002",
          "UMLS:C0035204"
        ],
        "synonyms": [
          "disease of respiratory system",
          "disease or disorder of respiratory system",
          "disorder of respiratory system",
          "respiratory disease",
          "respiratory disorder",
          "respiratory system disease",
          "respiratory system disease or disorder",
          "respiratory system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma."
      },
      "child_count": 59,
      "reference_id": "MONDO:0005087"
    }
  ],
  "children": [
    {
      "id": 6507,
      "label": "central sleep apnea syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        6990
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9220",
          "MEDGEN:854402",
          "MESH:D020182",
          "NCIT:C27169",
          "SCTID:27405005",
          "UMLS:C3887547"
        ],
        "synonyms": [
          "central sleep apnea syndrome",
          "central sleep apnea, primary",
          "primary central sleep apnea",
          "secondary central sleep apnea",
          "Apneas, central",
          "Apneas, central sleep",
          "Breathings, central sleep-disordered",
          "alveolar hypoventilation, central",
          "alveolar hypoventilations, central",
          "apnea, central",
          "apnea, central sleep",
          "apnea, sleep, central",
          "breathing, central sleep-disordered",
          "central Apneas",
          "central alveolar hypoventilation",
          "central alveolar hypoventilation syndrome",
          "central apnea",
          "central sleep Apneas",
          "central sleep apnea",
          "central sleep apnea, secondary",
          "central sleep disordered breathing",
          "central sleep-disordered Breathings",
          "central sleep-disordered breathing",
          "hypoventilation, central alveolar",
          "hypoventilations, central alveolar",
          "ondine syndrome",
          "sleep Apneas, central",
          "sleep apnea, lethal central",
          "sleep disordered breathing, central",
          "sleep-disordered Breathings, central",
          "sleep-disordered breathing, central"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A broad classification of disorders which includes 6 subtypes (primary central sleep apnea, central sleep apnea due to Cheyne-Stokes breathing pattern, central sleep apnea due to medical condition not Cheyne-Stokes, central sleep apnea due to high-altitude periodic breathing, central sleep apnea due to drug or substance and primary sleep apnea of infancy) that are each characterized by interruptions in breathing while asleep. It is caused by improper signaling from the brainstem to respiratory muscles and is triggered by either hypoventilation or hyperventilation. In adults, this disorder may arise following a stroke, congestive heart failure, trauma, infection or the use of narcotic medications. It is more common in older males and may present as a co-morbid condition to obesity. Clinical signs include snoring, insomnia or hypersomnia, difficulty concentrating and fatigue. Recurrent episodes of hypoxia/hypoxemia have long-term detrimental effects on cardiovascular health."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004731"
    },
    {
      "id": 8555,
      "label": "obstructive sleep apnea syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        6990
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050848",
          "EFO:0003918",
          "HP:0002870",
          "ICD10CM:G47.33",
          "ICD9:327.23",
          "MEDGEN:101045",
          "MESH:D020181",
          "NCIT:C27168",
          "OMIM:107650",
          "SCTID:78275009",
          "UMLS:C0520679"
        ],
        "synonyms": [
          "obstructive sleep apnea",
          "obstructive sleep apnea syndrome",
          "Apneas, obstructive sleep",
          "OSAHS",
          "Osa",
          "apnea, obstructive sleep",
          "obstructive sleep Apneas",
          "sleep Apneas, obstructive",
          "sleep apnea hypopnea syndrome",
          "sleep apnea syndrome, obstructive",
          "sleep apnea/hypopnea syndrome",
          "syndrome, obstructive sleep apnea",
          "syndrome, sleep apnea, obstructive",
          "syndrome, upper airway resistance, sleep apnea",
          "upper airway resistance sleep apnea syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Cessation of air flow during sleep due to upper airway obstruction."
      },
      "child_count": 2,
      "reference_id": "MONDO:0007147"
    }
  ],
  "roots": [
    {
      "id": 5338,
      "label": "sleep-wake disorder"
    },
    {
      "id": 6815,
      "label": "respiratory system disorder"
    }
  ]
}