{
  "id": 6992,
  "label": "osteoporosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005298",
  "properties": {
    "xrefs": [
      "DOID:11476",
      "EFO:0003882",
      "ICD10CM:M81",
      "ICD9:733.0",
      "ICD9:733.00",
      "ICD9:733.09",
      "MEDGEN:14535",
      "MESH:D010024",
      "NCIT:C3298",
      "OMIM:166710",
      "SCTID:64859006",
      "UMLS:C0029456",
      "icd11.foundation:2113001430"
    ],
    "synonyms": [
      "bone mineral density variation QTL, osteoporosis",
      "osteoporosis, postmenopausal",
      "osteoporosis, postmenopausal, susceptibility",
      "osteoporosis, susceptibility to",
      "fracture, hip, susceptibility to",
      "osteoporosis, involutional"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 3153,
      "label": "bone resorption disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080011",
          "MEDGEN:14188",
          "MESH:D001862",
          "UMLS:C0005974"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A disease that has its basis in the disruption of bone resorption. Bone resorption is a process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products."
      },
      "child_count": 3,
      "reference_id": "MONDO:0000837"
    },
    {
      "id": 24803,
      "label": "osteogenesis imperfecta and a reduction of bone mineral density.",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18933
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026427",
          "HP:0004349"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A skeletal dysplasia characterized by osteogenesis imperfecta and decreased bone density."
      },
      "child_count": 34,
      "reference_id": "MONDO:0800064"
    },
    {
      "id": 25070,
      "label": "metabolic bone disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7061
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:2699",
          "NCIT:C97045",
          "UMLS:C0005944"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A group of disorders that affect the bones secondary to increased levels of minerals or deficient levels of minerals such as calcium, magnesium, phosphorus, and vitamin D. Representative examples are osteomalacia, osteoporosis, and Paget disease."
      },
      "child_count": 4,
      "reference_id": "MONDO:0800486"
    }
  ],
  "children": [
    {
      "id": 2718,
      "label": "nephrolithiasis/osteoporosis, hypophosphatemic",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6992
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080655",
          "GARD:0022708",
          "OMIMPS:612286"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0000079"
    },
    {
      "id": 9470,
      "label": "postmenopausal osteoporosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6992
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003854",
          "MEDGEN:10498",
          "MESH:D015663",
          "SCTID:102447009",
          "UMLS:C0029458",
          "icd11.foundation:123797893"
        ],
        "synonyms": [
          "bone mineral density quantitative trait locus",
          "osteoporosis, postmenopausal"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008159"
    },
    {
      "id": 18411,
      "label": "X-linked osteoporosis with fractures",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6992
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017614",
          "MEDGEN:1674557",
          "Orphanet:391330",
          "UMLS:C5190610"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018315"
    },
    {
      "id": 19238,
      "label": "idiopathic juvenile osteoporosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6992,
        7203,
        21247,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12559",
          "GARD:0006760",
          "ICD9:733.02",
          "MEDGEN:120494",
          "MESH:C537700",
          "NCIT:C119996",
          "OMIM:259750",
          "Orphanet:85193",
          "SCTID:3345002",
          "UMLS:C0264080",
          "icd11.foundation:183642011"
        ],
        "synonyms": [
          "IJO",
          "Ijo",
          "Paediatric osteoporosis",
          "Pediatric osteoporosis",
          "idiopathic juvenile osteoporosis",
          "juvenile osteoporosis",
          "osteoporosis, juvenile"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Idiopathic juvenile osteoporosis (IJO) is a primary condition of bone demineralization childhood or adolescence that presents with pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis. Onset usually occurs in the prepubertal period, between 8 and 12 years of age."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019409"
    },
    {
      "id": 21558,
      "label": "drug-induced osteoporosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6992
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025446",
          "ICD9:733.09",
          "MEDGEN:538336",
          "SCTID:14651005",
          "UMLS:C0264115",
          "icd11.foundation:691296096"
        ],
        "synonyms": [
          "drug-induced osteoporosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0024650"
    },
    {
      "id": 23935,
      "label": "pregnancy associated osteoporosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6992,
        21520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026077"
        ],
        "synonyms": [
          "pregnancy and lactation-associated osteoporosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A severe early presentation of osteoporosis in which young women experience low trauma or spontaneous fractures, most commonly vertebral fractures, during late pregnancy or lactation."
      },
      "child_count": 2,
      "reference_id": "MONDO:0100194"
    },
    {
      "id": 24443,
      "label": "premenopausal osteoporosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6992
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026335"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Osteoporosis occurring in premenopausal women with existing fragility fractures, diseases or treatments known to cause bone loss or fractures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0700047"
    }
  ],
  "roots": [
    {
      "id": 3153,
      "label": "bone resorption disease"
    },
    {
      "id": 24803,
      "label": "osteogenesis imperfecta and a reduction of bone mineral density."
    },
    {
      "id": 25070,
      "label": "metabolic bone disorder"
    }
  ]
}