{
  "id": 7047,
  "label": "Graves disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005364",
  "properties": {
    "xrefs": [
      "DOID:12361",
      "EFO:0004237",
      "ICD9:242.0",
      "MEDGEN:6677",
      "MESH:D006111",
      "NANDO:2200328",
      "NCIT:C3071",
      "SCTID:353295004",
      "UMLS:C0018213"
    ],
    "synonyms": [
      "Graves disease",
      "Basedow disease",
      "Graves' hyperthyroidism",
      "parry disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 3354,
      "label": "toxic diffuse goiter",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6233,
        7075
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10719",
          "ICD10CM:E05.0",
          "ICD9:242.00",
          "MEDGEN:488851",
          "SCTID:267374005",
          "UMLS:C0342122"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0001104"
    },
    {
      "id": 7262,
      "label": "autoimmune thyroid disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2997,
        5955
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006812",
          "MEDGEN:183088",
          "MESH:D013967",
          "UMLS:C0920350",
          "Wikipedia:Autoimmune_thyroiditis"
        ],
        "synonyms": [
          "autoimmune thyroid gland inflammation",
          "autoimmune thyroiditides",
          "autoimmune thyroiditis",
          "lymphocytic thyroiditides",
          "lymphocytic thyroiditis",
          "lymphomatous thyroiditides",
          "lymphomatous thyroiditis",
          "thyroiditides, autoimmune",
          "thyroiditides, lymphocytic",
          "thyroiditides, lymphomatous",
          "thyroiditis, lymphocytic",
          "thyroiditis, lymphomatous"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005623"
    },
    {
      "id": 29358,
      "label": "primary hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:811409",
          "UMLS:C3714618"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of hyperthyroidism caused by overproduction of thyroid hormones (T3 and T4) due to pathology within the thyroid gland itself. Primary hyperthyroidism is characterized by low TSH levels and elevated T3/T4 levels."
      },
      "child_count": 3,
      "reference_id": "MONDO:1060200"
    }
  ],
  "children": [
    {
      "id": 22754,
      "label": "pediatric-onset Graves disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7047
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022190",
          "MEDGEN:1842979",
          "Orphanet:525731",
          "UMLS:C5680179"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare endocrine disease characterized by the presence of serum autoantibodies against thyroid-stimulating hormone receptors, leading to excessive thyroid hormone production and a swollen thyroid gland. Children with this disease typically experience symptoms of an overactive thyroid, including rapid heartbeat, weight loss, tremors, and excessive sweating."
      },
      "child_count": 0,
      "reference_id": "MONDO:0033925"
    }
  ],
  "roots": [
    {
      "id": 3354,
      "label": "toxic diffuse goiter"
    },
    {
      "id": 7262,
      "label": "autoimmune thyroid disease"
    },
    {
      "id": 29358,
      "label": "primary hyperthyroidism"
    }
  ]
}