{
  "id": 7053,
  "label": "male infertility",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005372",
  "properties": {
    "xrefs": [
      "DOID:12336",
      "EFO:0004248",
      "ICD10CM:N46",
      "ICD10WHO:N46",
      "ICD9:606",
      "ICD9:606.9",
      "MEDGEN:5796",
      "MESH:D007248",
      "SCTID:2904007",
      "UMLS:C0021364",
      "icd11.foundation:753457327"
    ],
    "synonyms": [
      "infertility disorder of male reproductive system",
      "male reproductive system infertility",
      "male reproductive system infertility disorder"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 5121,
      "label": "male reproductive system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:48",
          "EFO:0009555",
          "ICD10CM:N40-N53",
          "ICD10WHO:N40-N51",
          "ICD9:600-608",
          "ICD9:608.9",
          "MEDGEN:66734",
          "MESH:D005832",
          "NCIT:C27019",
          "SCTID:363194005",
          "UMLS:C0236099"
        ],
        "synonyms": [
          "Male reproductive system disease",
          "Male reproductive system disorder",
          "disease of male reproductive system",
          "disease or disorder of male reproductive system",
          "disorder of Male reproductive system",
          "disorder of male reproductive system",
          "male reproductive disease",
          "male reproductive system disease",
          "male reproductive system disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A disease involving the male reproductive system."
      },
      "child_count": 26,
      "reference_id": "MONDO:0003150"
    },
    {
      "id": 6779,
      "label": "infertility disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5223",
          "EFO:0000545",
          "MEDGEN:43876",
          "MESH:D007246",
          "NCIT:C3836",
          "UMLS:C0021359"
        ],
        "synonyms": [
          "Sterile",
          "fertility disorders",
          "infertile",
          "sterile",
          "sterility",
          "infertility"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Inability to conceive for at least one year after trying and having unprotected sex. Causes of female infertility include endometriosis, fallopian tubes obstruction, and polycystic ovary syndrome. Causes of male infertility include abnormal sperm production or function, blockage of the epididymis, blockage of the ejaculatory ducts, hypospadias, exposure to pesticides, and health related issues."
      },
      "child_count": 5,
      "reference_id": "MONDO:0005047"
    }
  ],
  "children": [
    {
      "id": 4052,
      "label": "infertility due to extratesticular cause",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14096",
          "ICD9:606.8",
          "MEDGEN:507846",
          "SCTID:84245004",
          "UMLS:C0021360"
        ],
        "synonyms": [
          "infertility due to extratesticular causes"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A male infertility disorder caused by conditions external to the testis, such as hormonal imbalances, reproductive tract obstructions, or systemic illness."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001877"
    },
    {
      "id": 4085,
      "label": "oligospermia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14228",
          "HP:0000798",
          "ICD10CM:N46.1",
          "ICD9:606.1",
          "MEDGEN:18162",
          "MESH:D009845",
          "UMLS:C0028960",
          "icd11.foundation:1497721709"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Decreased number of spermatozoa in the semen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001913"
    },
    {
      "id": 6724,
      "label": "spermatogenic failure",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111910",
          "EFO:0000279",
          "MEDGEN:766708",
          "OMIMPS:258150",
          "UMLS:C3553794"
        ],
        "synonyms": [
          "spermatogenic failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A male infertility characterized by dirsuption of the process of sperm development from diploid cells into mature haploid spermatozoa."
      },
      "child_count": 226,
      "reference_id": "MONDO:0004983"
    },
    {
      "id": 16401,
      "label": "partial chromosome Y deletion",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3128,
        7053,
        24426
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016574",
          "HGNC:11311",
          "MEDGEN:267211",
          "MESH:C536297",
          "Orphanet:1646",
          "SCTID:717158001",
          "UMLS:C1507149"
        ],
        "synonyms": [
          "Male sterility due to chromosome Y deletion",
          "Y-chromosome microdeletions",
          "partial deletion of Y",
          "partial deletion of Y chromosome short arm",
          "partial deletion of chromosome Y",
          "partial deletion of the long arm of the Y chromosome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A genetic male infertility characterized by azoospermia or oligozoospermia due to chromosome Y microdeletion."
      },
      "child_count": 9,
      "reference_id": "MONDO:0015607"
    },
    {
      "id": 18463,
      "label": "male infertility with teratozoospermia due to single gene mutation",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017654",
          "MEDGEN:1643966",
          "Orphanet:399808",
          "SCTID:764096006",
          "UMLS:C4706677"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A rare, genetic male infertility due to sperm disorder characterized by the presence of spermatozoa with abnormal morphology, such as macrozoospermia or globozoospermia, in over 85% of sperm, resulting from mutation in a single gene known to cause teratozoospermia. It is a heterogeneous group that includes a wide range of abnormal sperm phenotypes affecting, solely or simultaneously, head, neck, midpiece, and/or tail."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018394"
    },
    {
      "id": 22807,
      "label": "male infertility due to acephalic spermatozoa",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0112311",
          "GARD:0017971",
          "Orphanet:529970"
        ],
        "synonyms": [
          "Acephalic spermatozoa syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A male infertility disorder characterized by defective sperm morphology, specifically the absence of the sperm head which prevents natural or assisted fertilization."
      },
      "child_count": 0,
      "reference_id": "MONDO:0035153"
    },
    {
      "id": 24186,
      "label": "azoospermia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14227",
          "ICD10CM:N46.0",
          "ICD9:606.0",
          "MEDGEN:2150",
          "MESH:D053713",
          "SCTID:425558002",
          "UMLS:C0004509",
          "icd11.foundation:532688254"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A male infertility disease characterized by the absence of any measurable level of sperm in semen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100459"
    },
    {
      "id": 25136,
      "label": "oligoasthenoteratozoospermia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7053
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070311"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A form of male infertility that is characterized by a combination of low number or oligozoospermia, poor motility or asthenozoospermia, and abnormal shape or teratozoospermia of sperms. OAT is the most common cause of male subfertility."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850098"
    }
  ],
  "roots": [
    {
      "id": 5121,
      "label": "male reproductive system disorder"
    },
    {
      "id": 6779,
      "label": "infertility disorder"
    }
  ]
}