{
  "id": 7058,
  "label": "nephrotic syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005377",
  "properties": {
    "xrefs": [
      "DOID:1184",
      "EFO:0004255",
      "GARD:0027721",
      "ICD10CM:N04",
      "ICD10WHO:N04",
      "ICD9:581",
      "ICD9:581.9",
      "MEDGEN:10308",
      "MESH:D009404",
      "NANDO:2100009",
      "NCIT:C34845",
      "SCTID:52254009",
      "UMLS:C0027726",
      "icd11.foundation:1184209951"
    ],
    "synonyms": [
      "nephrotic syndrome",
      "nephrotic syndromes",
      "syndrome, nephrotic",
      "syndromes, nephrotic",
      "nephrosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 4437,
      "label": "nephrosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6948
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2527",
          "MEDGEN:10223",
          "MESH:D009401",
          "UMLS:C0027720"
        ],
        "synonyms": [
          "Nephroses"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002331"
    }
  ],
  "children": [
    {
      "id": 4449,
      "label": "familial nephrotic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7058,
        23932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2590",
          "GARD:0027602",
          "MEDGEN:502251",
          "NCIT:C35337",
          "OMIMPS:256300",
          "SCTID:48796009",
          "UMLS:C3501848",
          "icd11.foundation:1524476844"
        ],
        "synonyms": [
          "congenital nephrotic syndrome",
          "hereditary nephrotic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "An instance of nephrotic syndrome that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002350"
    },
    {
      "id": 18314,
      "label": "idiopathic nephrotic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7058,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021539",
          "MEDGEN:501252",
          "NANDO:1200719",
          "NCIT:C122796",
          "Orphanet:357502",
          "UMLS:C3496337"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Nephrotic syndrome for which no cause has been identified."
      },
      "child_count": 10,
      "reference_id": "MONDO:0018170"
    },
    {
      "id": 23145,
      "label": "nephrotic syndrome ocular anomalies",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7058
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027967",
          "MEDGEN:419736",
          "MESH:C536403",
          "UMLS:C2931188"
        ],
        "synonyms": [
          "Glastre Cochat Bouvier syndrome",
          "familial infantile nephrotic syndrome with ocular abnormalities"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0043156"
    },
    {
      "id": 23429,
      "label": "steroid-resistant nephrotic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7058
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027973",
          "GTR:AN0096391",
          "GTR:AN0096395",
          "GTR:AN0200342",
          "GTR:AN0255485",
          "MEDGEN:588369",
          "NCIT:C122798",
          "SCTID:236381000",
          "UMLS:C0403397"
        ],
        "synonyms": [
          "nephrotic syndrome of childhood - steroid resistant",
          "nephrotic syndrome-steroid-resistant",
          "steroid-resistant nephrotic syndrome",
          "nephrotic syndrome, idiopathic, steroid-resistant",
          "nephrotic syndrome, steroid-resistant, autosomal recessive",
          "NPHS2",
          "SRNS - steroid-resistant nephrotic syndrome",
          "steroid-unresponsive nephrotic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Nephrotic syndrome, occurring in the pediatric population, in which proteinuria does not normalize with administration of steroids; this condition is unresponsive to a minimum of four weeks administration of oral corticosteroids."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044765"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 4437,
      "label": "nephrosis"
    }
  ]
}