{
  "id": 7062,
  "label": "bone Paget disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005382",
  "properties": {
    "xrefs": [
      "DOID:5408",
      "EFO:0004261",
      "ICD10CM:M88",
      "MEDGEN:10493",
      "NCIT:C3292",
      "OMIMPS:167250",
      "Orphanet:280110",
      "SCTID:2089002",
      "UMLS:C0029401"
    ],
    "synonyms": [
      "Paget disease of bone",
      "Paget's bone disease",
      "Paget's disease of bone",
      "Paget's disease of the bone",
      "Pagets disease (bone)",
      "bone Paget disease",
      "bone Paget's disease",
      "osseous Paget's disease",
      "osteitis deformans",
      "Paget's disease",
      "familial Paget's disease of bone"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4308,
      "label": "hyperostosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3151
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:205",
          "ICD10CM:M89.3",
          "ICD9:733.99",
          "MEDGEN:9366",
          "MESH:D015576",
          "NCIT:C34712",
          "SCTID:203514008",
          "UMLS:C0020492"
        ],
        "synonyms": [
          "bone hypertrophy",
          "hypertrophy of bone",
          "hypertrophy of bone (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Excessive thickening of bone."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002185"
    },
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 25070,
      "label": "metabolic bone disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7061
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:2699",
          "NCIT:C97045",
          "UMLS:C0005944"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A group of disorders that affect the bones secondary to increased levels of minerals or deficient levels of minerals such as calcium, magnesium, phosphorus, and vitamin D. Representative examples are osteomalacia, osteoporosis, and Paget disease."
      },
      "child_count": 4,
      "reference_id": "MONDO:0800486"
    }
  ],
  "children": [
    {
      "id": 9487,
      "label": "Paget disease of bone 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7062,
        25050
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081366",
          "GARD:0004191",
          "MEDGEN:895927",
          "OMIM:167250",
          "UMLS:C4085252"
        ],
        "synonyms": [
          "Paget disease of bone 3",
          "Paget disease of bone type 3",
          "PDB3",
          "Paget disease of bone, familial",
          "familial Paget disease of bone"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008176"
    },
    {
      "id": 10626,
      "label": "juvenile Paget disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7062
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081368",
          "GARD:0002831",
          "MEDGEN:75678",
          "MESH:C537701",
          "NCIT:C131861",
          "NORD:1230",
          "OMIM:239000",
          "Orphanet:2801",
          "SCTID:9723006",
          "UMLS:C0268414",
          "icd11.foundation:762002965"
        ],
        "synonyms": [
          "Hereditary Hyperphosphatasia",
          "JPG",
          "familial hyperphosphatasia",
          "familial osteoectasia",
          "hereditary hyperphosphatasia",
          "hyperostosis corticalis deformans juvenilis",
          "juvenile Paget disease",
          "juvenile Paget's disease",
          "JPD",
          "PDB5",
          "Paget disease juvenile type",
          "Paget disease of bone 5, juvenile-onset",
          "hyperostosid corticalis deformans juvenilis",
          "hyperphosphatasemia, chronic congenital idiopathic",
          "hyperphosphatasia, familial idiopathic",
          "juvenile Pagets disease",
          "osteoectasia, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Juvenile Paget disease is a very rare form of Paget disease of the bone characterized by a general increase in bone turnover with increased bone resorption and deposition, resulting in cortical and trabecular thickening, and clinically presenting as progressive skeletal deformities, growth impairment, fractures, vertebral collapse, skull enlargement and sensorineural hearing loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009394"
    },
    {
      "id": 12305,
      "label": "Paget disease of bone 2, early-onset",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7062,
        19478
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081365",
          "GARD:0024779",
          "MEDGEN:899166",
          "OMIM:602080",
          "UMLS:C4085251"
        ],
        "synonyms": [
          "Paget disease of bone 2, early-onset",
          "PDB2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011183"
    },
    {
      "id": 12748,
      "label": "paget disease of bone 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7062
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081367",
          "MEDGEN:339991",
          "MESH:C565240",
          "OMIM:606263",
          "UMLS:C1853473"
        ],
        "synonyms": [
          "PDB4",
          "Paget disease of bone 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011656"
    },
    {
      "id": 15780,
      "label": "Paget disease of bone 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7062
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081369",
          "MEDGEN:908743",
          "OMIM:616833",
          "UMLS:C4085250"
        ],
        "synonyms": [
          "PDB6",
          "Paget disease of bone 6",
          "Paget disease of bone 6; PDB6",
          "Paget disease of bone type 6"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0014792"
    }
  ],
  "roots": [
    {
      "id": 4308,
      "label": "hyperostosis"
    },
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 25070,
      "label": "metabolic bone disorder"
    }
  ]
}