{
  "id": 7067,
  "label": "primary ovarian failure",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005387",
  "properties": {
    "xrefs": [
      "DOID:5426",
      "EFO:0004266",
      "ICD10CM:E28.3",
      "ICD9:253.4",
      "ICD9:256.39",
      "MEDGEN:38820",
      "MESH:D016649",
      "NANDO:2100139",
      "NCIT:C113352",
      "Orphanet:619",
      "SCTID:370999003",
      "SCTID:65846009",
      "UMLS:C0085215"
    ],
    "synonyms": [
      "primary ovarian failure",
      "female hypergonadotropic hypogonadism",
      "hypergonadotrophic ovarian failure",
      "hypergonadotropic hypogonadism",
      "hypergonadotropic hypogonadism (female)",
      "premature menopause",
      "premature ovarian failure",
      "premature ovarian insufficiency",
      "primary female hypogonadism"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4064,
      "label": "ovarian dysfunction",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7207
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1414",
          "EFO:0009003",
          "ICD10CM:E28",
          "ICD10WHO:E28",
          "ICD9:256.3",
          "ICD9:256.39",
          "ICD9:256.8",
          "ICD9:256.9",
          "MEDGEN:509544",
          "NCIT:C113351",
          "SCTID:37102008",
          "UMLS:C0154208",
          "icd11.foundation:1801368748"
        ],
        "synonyms": [
          "ovarian failure",
          "ovarian hypofunction",
          "ovarian insufficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "The inability of the ovaries to function."
      },
      "child_count": 1,
      "reference_id": "MONDO:0001889"
    }
  ],
  "children": [
    {
      "id": 3367,
      "label": "premature menopause",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7067
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10787",
          "EFO:0009005",
          "ICD10CM:E28.31",
          "ICD9:256.31",
          "ICD9:256.39",
          "MEDGEN:9963",
          "MESH:D008594",
          "NCIT:C80099",
          "SCTID:237788002",
          "UMLS:C0025322"
        ],
        "synonyms": [
          "POF",
          "early menopause",
          "premature menopause",
          "premature ovarian failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Cessation of menstruation before the age of 40. Symptoms include hot flashes, night sweats, mood swings, and decreased sex drive."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001119"
    },
    {
      "id": 19577,
      "label": "acquired primary ovarian failure",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7067
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1863413",
          "Orphanet:95709",
          "SCTID:717954003",
          "UMLS:C5925051"
        ],
        "synonyms": [
          "acquired primary ovarian failure",
          "acquired premature ovarian failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of primary ovarian failure that is acquired during the lifetime of the individual."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019851"
    },
    {
      "id": 19578,
      "label": "inherited primary ovarian failure",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7067,
        16330,
        20362
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019294",
          "MEDGEN:443920",
          "OMIMPS:311360",
          "Orphanet:95710",
          "UMLS:C2930861"
        ],
        "synonyms": [
          "hereditary primary ovarian failure",
          "inherited POI",
          "inherited premature ovarian failure",
          "inherited primary ovarian insufficiency",
          "non-acquired premature ovarian failure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of primary ovarian failure that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 164,
      "reference_id": "MONDO:0019852"
    },
    {
      "id": 23340,
      "label": "autoimmune primary ovarian failure",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2997,
        7067
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:256.39",
          "ICD9:279.49",
          "MEDGEN:575071",
          "SCTID:237790001",
          "UMLS:C0342508"
        ],
        "synonyms": [
          "primary ovarian failure arising through autoimmunity"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autoimmune form of primary ovarian failure."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044338"
    }
  ],
  "roots": [
    {
      "id": 4064,
      "label": "ovarian dysfunction"
    }
  ]
}