{
  "id": 7107,
  "label": "embryonal carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005440",
  "properties": {
    "xrefs": [
      "DOID:3308",
      "EFO:0004986",
      "GARD:0005140",
      "ICDO:9070/3",
      "MEDGEN:61653",
      "MESH:D018236",
      "NANDO:2200067",
      "NCIT:C3752",
      "ONCOTREE:EMBCA",
      "Orphanet:180226",
      "UMLS:C0206659"
    ],
    "synonyms": [
      "carcinoma, embryonal, malignant",
      "embryonal carcinoma",
      "primary extragonadal embryonal carcinoma"
    ],
    "definition": "A non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 5475,
      "label": "extragonadal nonseminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5094,
        19983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5677",
          "GARD:0023567",
          "MEDGEN:233662",
          "NCIT:C8885",
          "UMLS:C1334582"
        ],
        "synonyms": [
          "cancer of extragonadal non-seminomatous germ cell",
          "cancer of the extragonadal non-seminomatous germ cell",
          "extragonadal non-seminomatous germ cell cancer",
          "extragonadal primary Nonseminoma",
          "malignant extragonadal Nonseminoma",
          "malignant extragonadal non-seminomatous germ cell neoplasm",
          "malignant extragonadal non-seminomatous germ cell tumor",
          "malignant extragonadal non-seminomatous germ cell tumour",
          "malignant neoplasm of extragonadal non-seminomatous germ cell",
          "malignant neoplasm of the extragonadal non-seminomatous germ cell",
          "malignant tumor of extragonadal non-seminomatous germ cell",
          "malignant tumor of the extragonadal non-seminomatous germ cell",
          "malignant tumour of extragonadal non-seminomatous germ cell",
          "malignant tumour of the extragonadal non-seminomatous germ cell",
          "primary malignant extragonadal Nonseminoma"
        ],
        "definition": "A malignant non-seminomatous germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary."
      },
      "child_count": 20,
      "reference_id": "MONDO:0003578"
    }
  ],
  "children": [
    {
      "id": 5477,
      "label": "ovarian embryonal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7107,
        16723
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5681",
          "EFO:1000415",
          "GARD:0023568",
          "MEDGEN:91090",
          "NCIT:C8108",
          "ONCOTREE:OEC",
          "SCTID:254872007",
          "UMLS:C0346183"
        ],
        "synonyms": [
          "embryonal carcinoma of ovary",
          "embryonal carcinoma of the ovary",
          "ovarian embryonal carcinoma",
          "ovary embryonal carcinoma",
          "embryonal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An embryonal carcinoma arising from the ovary. Signs and symptoms include the presence of an abdominal mass and abdominal pain."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003581"
    },
    {
      "id": 7953,
      "label": "testicular embryonal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4887,
        5335,
        7107,
        7212
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5680",
          "EFO:1000565",
          "GARD:0024413",
          "MEDGEN:66771",
          "NCIT:C6341",
          "UMLS:C0238448"
        ],
        "synonyms": [
          "embryonal carcinoma of testis",
          "embryonal carcinoma of the testis",
          "embryonal testis carcinoma",
          "testicular embryonal carcinoma",
          "testis embryonal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006446"
    },
    {
      "id": 17647,
      "label": "non-central nervous system-localized embryonal carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7107
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021137",
          "MEDGEN:1842755",
          "Orphanet:289362",
          "UMLS:C5679946"
        ],
        "synonyms": [
          "non-CNS-localized embryonal carcinoma"
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017328"
    },
    {
      "id": 18779,
      "label": "embryonal carcinoma of the central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        7107,
        20012
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7232",
          "GARD:0018836",
          "MEDGEN:272566",
          "NCIT:C7010",
          "ONCOTREE:BEC",
          "Orphanet:48736",
          "UMLS:C1333377"
        ],
        "synonyms": [
          "central nervous system embryonal carcinoma",
          "embryonal carcinoma of CNS",
          "embryonal carcinoma of the CNS",
          "embryonal carcinoma of the central nervous system",
          "embryonal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A embryonal carcinoma that involves the central nervous system."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018843"
    }
  ],
  "roots": [
    {
      "id": 5475,
      "label": "extragonadal nonseminomatous germ cell tumor"
    }
  ]
}