{
  "id": 7111,
  "label": "testicular cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005447",
  "properties": {
    "xrefs": [
      "DOID:2998",
      "EFO:0005088",
      "ICD10CM:C62",
      "ICD9:186",
      "ICD9:186.9",
      "MEDGEN:56313",
      "MESH:D013736",
      "NCIT:C7251",
      "SCTID:363449006",
      "UMLS:C0153594"
    ],
    "synonyms": [
      "testicular tumor",
      "testicular tumour",
      "testis neoplasm",
      "cancer of testis",
      "malignant neoplasm of testis",
      "malignant neoplasm of the testis",
      "malignant testicular neoplasm",
      "malignant testicular tumor",
      "malignant testicular tumour",
      "malignant testis neoplasm",
      "malignant tumor of testis",
      "malignant tumor of the testis",
      "malignant tumour of testis",
      "malignant tumour of the testis",
      "testis cancer",
      "paediatric testicular neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A primary or metastatic malignant neoplasm that affects the testis. Representative examples include seminoma, embryonal carcinoma, sarcoma, leukemia, and lymphoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 7450,
      "label": "male reproductive organ cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        21521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3856",
          "EFO:0007355",
          "ICD9:187.8",
          "ICD9:187.9",
          "MEDGEN:102279",
          "MESH:D005834",
          "NCIT:C8561",
          "SCTID:363515000",
          "UMLS:C0153606"
        ],
        "synonyms": [
          "male genital neoplasm",
          "male reproductive system neoplasm",
          "neoplasm of male genital organ",
          "tumor of male reproductive system",
          "tumour of male reproductive system",
          "cancer of male reproductive organ",
          "male reproductive organ cancer",
          "malignant Male reproductive system neoplasm",
          "malignant Male reproductive system tumor",
          "malignant Male reproductive system tumour",
          "malignant male reproductive organ neoplasm",
          "malignant neoplasm of Male reproductive system",
          "malignant neoplasm of male genital organ, site unspecified",
          "malignant neoplasm of male reproductive organ",
          "malignant neoplasm of the Male reproductive system",
          "malignant tumor of Male reproductive system",
          "malignant tumor of male genital organ",
          "malignant tumor of male reproductive system",
          "malignant tumor of the Male reproductive system",
          "malignant tumour of Male reproductive system",
          "malignant tumour of male genital organ",
          "malignant tumour of male reproductive system",
          "malignant tumour of the Male reproductive system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm involving the male reproductive system. Representative examples include prostate carcinoma, penile carcinoma, testicular seminoma, and testicular embryonal carcinoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005836"
    },
    {
      "id": 20517,
      "label": "neoplasm of testis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4435,
        21521
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:239.5",
          "MEDGEN:52675",
          "NCIT:C3404",
          "ONCOTREE:TESTIS",
          "SCTID:126900000",
          "UMLS:C0039590"
        ],
        "synonyms": [
          "neoplasm of testis",
          "neoplasm of the testis",
          "testicular neoplasm",
          "testicular tumor",
          "testicular tumour",
          "testis neoplasm",
          "testis neoplasm (disease)",
          "testis tumor",
          "testis tumour",
          "tumor of testis",
          "tumor of the testis",
          "tumour of testis",
          "tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the testis."
      },
      "child_count": 16,
      "reference_id": "MONDO:0021348"
    }
  ],
  "children": [
    {
      "id": 2878,
      "label": "malignant Sertoli-Leydig cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4559,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050618"
        ],
        "synonyms": [
          "Sertoli-Leydig cell tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant form of Sertoli-leydig cell tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0000379"
    },
    {
      "id": 3686,
      "label": "testicular lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12253",
          "GARD:0022950",
          "ICD9:186.9",
          "MEDGEN:138110",
          "NCIT:C6810",
          "ONCOTREE:TLYM",
          "SCTID:277664004",
          "UMLS:C0349644"
        ],
        "synonyms": [
          "lymphoma of testis",
          "lymphoma of the testis",
          "primary testicular lymphoma",
          "testicular lymphoma",
          "TLYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A lymphoma that arises from the testis and is not associated with lymphoma in another anatomic site."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001472"
    },
    {
      "id": 3693,
      "label": "malignant tumor of undescended testis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12276",
          "ICD10CM:C62.0",
          "ICD9:186.0",
          "MEDGEN:509335",
          "SCTID:188219004",
          "UMLS:C0153595",
          "icd11.foundation:222947236"
        ],
        "synonyms": [
          "malignant neoplasm of retained testis",
          "malignant neoplasm of undescended testis",
          "malignant tumour of retained testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0001480"
    },
    {
      "id": 3695,
      "label": "testicular leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6789,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12286",
          "GARD:0022954",
          "MEDGEN:234941",
          "NCIT:C9277",
          "UMLS:C1336711"
        ],
        "synonyms": [
          "testicular leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A myeloid or more commonly lymphoid leukemia (acute or chronic) affecting the testis. Microscopically, there is interstitial infiltration of the testis by leukemic cells. Acute lymphoblastic leukemia with testicular involvement is not uncommon in boys. Sometimes (up to 10% of the cases), testicular involvement may be the initial manifestation of relapsed acute lymphoblastic leukemia. --03"
      },
      "child_count": 0,
      "reference_id": "MONDO:0001482"
    },
    {
      "id": 4151,
      "label": "rete testis adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5463,
        6712,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14544",
          "MEDGEN:209023",
          "NCIT:C8955",
          "UMLS:C0863024"
        ],
        "synonyms": [
          "adenocarcinoma of rete testis",
          "adenocarcinoma of the rete testis",
          "carcinoma, rete testis, malignant",
          "rete testis adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the rete testis"
      },
      "child_count": 0,
      "reference_id": "MONDO:0001992"
    },
    {
      "id": 4152,
      "label": "seminal vesicle adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4818,
        6712,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14545",
          "MEDGEN:311271",
          "NCIT:C39906",
          "UMLS:C1519233"
        ],
        "synonyms": [
          "seminal vesicle adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from glandular epithelial cells of the seminal vesicle"
      },
      "child_count": 0,
      "reference_id": "MONDO:0001993"
    },
    {
      "id": 4742,
      "label": "testicular gonadoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102,
        7111,
        11906
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3579",
          "GARD:0023215",
          "HP:0000030",
          "MEDGEN:272839",
          "NCIT:C39911",
          "UMLS:C1515283"
        ],
        "synonyms": [
          "gonadoblastoma of testis",
          "testicular gonadoblastoma",
          "testicular gonadoblastoma (disease)",
          "testis gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A testicular mixed germ cell-sex cord-stromal tumor. It is usually associated with mixed gonadal dysgenesis and ambiguous genitalia. It is characterized by the presence of nests of large neoplastic germ cells and immature cells that resemble Sertoli cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002698"
    },
    {
      "id": 4875,
      "label": "testis sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7111,
        18239
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4062",
          "GARD:0023278",
          "MEDGEN:234943",
          "NCIT:C6359",
          "UMLS:C1336727"
        ],
        "synonyms": [
          "sarcoma of testis",
          "sarcoma of the testis",
          "testicular sarcoma",
          "testis sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sarcoma that arises from the testis. The majority of cases arise from teratomas or spermatocytic seminomas."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002861"
    },
    {
      "id": 5424,
      "label": "malignant testicular germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7111,
        7832,
        11294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5556",
          "GARD:0023539",
          "ICD9:186.9",
          "MEDGEN:163616",
          "NCIT:C9063",
          "SCTID:713646001",
          "UMLS:C0855197"
        ],
        "synonyms": [
          "testicular cancer",
          "malignant germ cell neoplasm of testis",
          "malignant germ cell neoplasm of the testis",
          "malignant germ cell tumor of testis",
          "malignant germ cell tumor of the testis",
          "malignant germ cell tumour of testis",
          "malignant germ cell tumour of the testis",
          "malignant testicular germ cell neoplasm",
          "malignant testicular germ cell tumor",
          "testicular ca. (no germ/tropho.)",
          "testicular cancer (excluding germ cell or trophoblastic cancer)",
          "testicular germ cell cancer",
          "testicular malignant germ cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor predominantly affecting young men and often associated with cryptorchidism. Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor."
      },
      "child_count": 18,
      "reference_id": "MONDO:0003510"
    },
    {
      "id": 5617,
      "label": "malignant testicular Leydig cell tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2876,
        5101,
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6021",
          "GARD:0023641",
          "MEDGEN:271769",
          "NCIT:C39942",
          "UMLS:C1515288"
        ],
        "synonyms": [
          "testicular Leydig cell tumor, malignant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A Leydig cell tumor characterized by a large size, cellular atypia, high mitotic activity, vascular invasion and necrotic changes. The prognosis is usually poor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003737"
    },
    {
      "id": 18329,
      "label": "paratesticular adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7111
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021550",
          "MEDGEN:1678623",
          "Orphanet:363478",
          "UMLS:C5190800"
        ],
        "synonyms": [
          "adenocarcinoma of paratestis",
          "adenocarcinoma of the paratestis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018192"
    }
  ],
  "roots": [
    {
      "id": 7450,
      "label": "male reproductive organ cancer"
    },
    {
      "id": 20517,
      "label": "neoplasm of testis"
    }
  ]
}