{
  "id": 7117,
  "label": "lung neuroendocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005454",
  "properties": {
    "xrefs": [
      "DOID:5410",
      "EFO:0005220",
      "GARD:0024190",
      "ICD9:209.61",
      "MEDGEN:277303",
      "NCIT:C5670",
      "ONCOTREE:LNET",
      "SCTID:707594002",
      "UMLS:C1334452"
    ],
    "synonyms": [
      "lung NET",
      "lung neuroendocrine neoplasm",
      "lung neuroendocrine tumor",
      "lung neuroendocrine tumor, well differentiated, low or intermediate grade",
      "lung neuroendocrine tumour",
      "neuroendocrine neoplasm of lung",
      "neuroendocrine neoplasm of the lung",
      "pulmonary neuroendocrine neoplasm",
      "pulmonary neuroendocrine tumor",
      "pulmonary neuroendocrine tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A low, intermediate, or high grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:169",
          "EFO:1001901",
          "GARD:0009316",
          "ICD9:209",
          "ICD9:209-209",
          "ICD9:239.7",
          "MEDGEN:64652",
          "MESH:D018358",
          "NCIT:C188218",
          "NCIT:C3809",
          "Orphanet:877",
          "SCTID:255046005",
          "UMLS:C0206754"
        ],
        "synonyms": [
          "APUDoma",
          "neuroendocrine neoplasm",
          "neuroendocrine tumor",
          "neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Endocrine tumors, also referred to as neuroendocrine tumors (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumors may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumors or for a clinical syndrome caused by abnormal hormone secretion)."
      },
      "child_count": 14,
      "reference_id": "MONDO:0019496"
    },
    {
      "id": 20356,
      "label": "lung neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6971,
        20056,
        20518
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:7400",
          "MESH:D008175",
          "NCIT:C3200",
          "ONCOTREE:LUNG",
          "UMLS:C0024121"
        ],
        "synonyms": [
          "lung neoplasm",
          "lung neoplasm (disease)",
          "lung neoplasms",
          "lung tumor",
          "lung tumour",
          "neoplasm of lung",
          "neoplasm of the lung",
          "tumor of lung",
          "tumor of the lung",
          "tumour of lung",
          "tumour of the lung",
          "lung",
          "neoplasm, lung",
          "neoplasm, pulmonary",
          "neoplasms, lung",
          "neoplasms, pulmonary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma."
      },
      "child_count": 30,
      "reference_id": "MONDO:0021117"
    }
  ],
  "children": [
    {
      "id": 5818,
      "label": "pulmonary large cell neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5040,
        6787,
        7117
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6658",
          "GARD:0023754",
          "MEDGEN:233608",
          "NCIT:C5672",
          "UMLS:C1334363"
        ],
        "synonyms": [
          "LCNEC of the lung",
          "large cell lung carcinoma with neuroendocrine differentiation",
          "large cell lung neuroendocrine carcinoma",
          "large cell neuroendocrine carcinoma of lung",
          "large cell neuroendocrine carcinoma of the lung",
          "lung large cell neuroendocrine carcinoma",
          "pulmonary large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A large cell neuroendocrine carcinoma that involves the lung(s)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003960"
    },
    {
      "id": 5934,
      "label": "lung mixed small cell and squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7117
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7081",
          "GARD:0023821",
          "MEDGEN:235331",
          "NCIT:C9423",
          "UMLS:C1334788"
        ],
        "synonyms": [
          "combined small cell and squamous cell lung carcinoma",
          "mixed small cell and squamous cell carcinoma of the lung",
          "small cell and squamous cell carcinoma of lung",
          "small cell and squamous cell carcinoma of the lung",
          "small cell and squamous cell lung carcinoma",
          "small cell and large cell carcinoma of the lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A lung carcinoma characterized by a combination of small cell carcinoma and squamous cell carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004100"
    },
    {
      "id": 7627,
      "label": "lung carcinoid tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7051,
        7117
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000037",
          "GARD:0024273",
          "MEDGEN:79070",
          "NCIT:C4038",
          "ONCOTREE:LUCA",
          "SCTID:254627002",
          "UMLS:C0280089"
        ],
        "synonyms": [
          "carcinoid tumor (disease) of lung",
          "carcinoid tumor of lung",
          "carcinoid tumor of the lung",
          "carcinoid tumour (disease) of lung",
          "carcinoid tumour of lung",
          "carcinoid tumour of the lung",
          "lung carcinoid tumor",
          "lung carcinoid tumor (disease)",
          "lung carcinoid tumour (disease)",
          "pulmonary carcinoid tumor",
          "pulmonary carcinoid tumour",
          "lung carcinoid"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine neoplasm that arises from the lung. It is characterized by the presence of uniform polygonal cells with small or moderate amount of cytoplasm and inconspicuous nucleoli. The cells are usually arranged in organoid and trabecular patterns. It is classified as typical or atypical carcinoid tumor based on the number of mitotic figures and the absence or presence of necrosis. Atypical carcinoid tumors have a worse prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006041"
    },
    {
      "id": 7728,
      "label": "combined lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        6862,
        7117,
        7464
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000200",
          "GARD:0024316",
          "MEDGEN:234166",
          "NCIT:C7591",
          "UMLS:C1333123"
        ],
        "synonyms": [
          "combined carcinoma of lung",
          "combined carcinoma of the lung",
          "combined lung cancer",
          "combined lung carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A lung carcinoma characterized by the presence of large or small neuroendocrine carcinoma cells in combination with malignant glandular or squamous epithelial cells."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006167"
    },
    {
      "id": 9726,
      "label": "small cell lung carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2894,
        6862,
        7117
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5409",
          "DOID:5411",
          "EFO:0000702",
          "GARD:0009344",
          "ICD9:162.9",
          "MEDGEN:57450",
          "MESH:D055752",
          "NCIT:C4917",
          "OMIM:182280",
          "ONCOTREE:SCLC",
          "Orphanet:70573",
          "SCTID:254632001",
          "UMLS:C0149925",
          "icd11.foundation:1800431439"
        ],
        "synonyms": [
          "SCLC",
          "oat cell carcinoma",
          "oat cell carcinoma (morphologic abnormality)",
          "poorly differentiated endocrine neoplasm",
          "Small cell lung cancer",
          "lung oat cell carcinoma",
          "lung small cell carcinoma",
          "lung small cell neuroendocrine carcinoma",
          "oat cell carcinoma of lung",
          "oat cell carcinoma of the lung",
          "oat cell lung carcinoma",
          "small cell cancer of the lung, somatic",
          "small cell carcinoma of lung",
          "small cell carcinoma of the lung",
          "small cell lung cancer",
          "small cell neuroendocrine carcinoma of lung",
          "small cell neuroendocrine carcinoma of the lung",
          "small-cell cancer of lung",
          "SCLC1",
          "small cell cancer of the lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized byrapid growth, and early metastasis. SCLC usually manifests as a large hilar mass with bulky mediastinal lymphadenopathy presenting clinically with chest pain, persistent cough, dyspnea, wheezing, hoarseness, hemoptysis, loss of appetite, weight loss, and neurological and endocrine paraneoplastic syndromes. SCLC is primarily reported in elderly people with a history of long-term tobacco exposure."
      },
      "child_count": 6,
      "reference_id": "MONDO:0008433"
    }
  ],
  "roots": [
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm"
    },
    {
      "id": 20356,
      "label": "lung neoplasm"
    }
  ]
}