{
  "id": 7120,
  "label": "endometrium adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005461",
  "properties": {
    "xrefs": [
      "DOID:2870",
      "EFO:0005232",
      "MEDGEN:218862",
      "NCIT:C7359",
      "UMLS:C1153706"
    ],
    "synonyms": [
      "endometrioid carcinoma of endometrium",
      "adenocarcinoma of endometrium",
      "adenocarcinoma of the endometrium",
      "adenocarcinoma, endometrial, malignant",
      "endometrial adenocarcinoma",
      "endometrioid adenoma or carcinoma NOS (morphologic abnormality)",
      "endometrioid adenomas and carcinomas (morphologic abnormality)",
      "endometrium adenocarcinoma",
      "endometrial endometrioid adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "An adenocarcinoma arising from the uterine body cavity. This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy. Most patients present with uterine bleeding and are over age 40 at the time of diagnosis. The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype. Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 4530,
      "label": "endometrial carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6929,
        13033
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2871",
          "EFO:1001512",
          "HP:0012114",
          "MEDGEN:96903",
          "NCIT:C7558",
          "ONCOTREE:UCEC",
          "SCTID:254878006",
          "UMLS:C0476089",
          "icd11.foundation:1123821211"
        ],
        "synonyms": [
          "endometrial cancer",
          "carcinoma of endometrium",
          "carcinoma of the endometrium",
          "carcinoma, endometrial, malignant",
          "endometrial carcinoma",
          "endometrial carcinoma (disease)",
          "endometrium carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant tumor arising from the epithelium that lines the cavity of the uterine body. The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases. Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma. Uterine bleeding is an initial clinical sign. The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002447"
    },
    {
      "id": 6712,
      "label": "adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        21312
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-0386",
          "DOID:299",
          "EFO:0000228",
          "ICDO:8140/3",
          "MEDGEN:122",
          "MESH:D000230",
          "NCIT:C2852",
          "ONCOTREE:ADNOS",
          "SCTID:443961001",
          "UMLS:C0001418"
        ],
        "synonyms": [
          "adenocarcinoma",
          "adenocarcinoma NOS (morphologic abnormality)",
          "adenocarcinoma, malignant",
          "adenocarcinoma, no subtype (morphologic abnormality)",
          "adenocarcinomas",
          "ADNOS"
        ],
        "definition": "A common cancer characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous). Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma."
      },
      "child_count": 128,
      "reference_id": "MONDO:0004970"
    }
  ],
  "children": [
    {
      "id": 4782,
      "label": "endometrial mucinous adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6700,
        7120
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3707",
          "EFO:1000236",
          "MEDGEN:276939",
          "NCIT:C40144",
          "ONCOTREE:UMC",
          "UMLS:C1519859",
          "icd11.foundation:395055399"
        ],
        "synonyms": [
          "endometrial mucinous adenocarcinoma",
          "endometrium mucinous adenocarcinoma",
          "uterine corpus mucinous adenocarcinoma",
          "uterine mucinous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary, usually low grade adenocarcinoma of the endometrium in which the majority of the malignant epithelial cells contain abundant intracytoplasmic mucin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002747"
    },
    {
      "id": 5844,
      "label": "villoglandular endometrial endometrioid adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5161,
        7120,
        7748
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6777",
          "MEDGEN:277869",
          "NCIT:C27846",
          "UMLS:C1336962"
        ],
        "synonyms": [
          "villoglandular endometrial endometrioid adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of numerous finger-like villi lined by neoplastic columnar cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003991"
    },
    {
      "id": 5867,
      "label": "oxyphilic endometrial endometrioid adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7120,
        7748
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6865",
          "MEDGEN:309527",
          "NCIT:C27849",
          "UMLS:C1518768"
        ],
        "synonyms": [
          "oxyphilic endometrial endometrioid adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of eosinophilic malignant glandular epithelial cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004019"
    },
    {
      "id": 5997,
      "label": "secretory uterine corpus endometrioid adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7120,
        7748
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7289",
          "ICDO:8382/3",
          "MEDGEN:690079",
          "NCIT:C27839",
          "UMLS:C1266057"
        ],
        "synonyms": [
          "endometrial endometrioid adenocarcinoma, secretory variant",
          "secretory uterine corpus endometrioid adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An endometrioid adenocarcinoma arising from the endometrium. Morphologically it is characterized by the presence of malignant glandular cells containing glycogen vacuoles which are usually subnuclear and reminiscent of early secretory endometrium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004174"
    },
    {
      "id": 5998,
      "label": "mucin-rich endometrial endometrioid adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7120,
        7748
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7293",
          "MEDGEN:269340",
          "NCIT:C8717",
          "UMLS:C1513711"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004175"
    },
    {
      "id": 6042,
      "label": "endometrial endometrioid adenocarcinoma with spindled epithelial cells",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7120,
        7748
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7436",
          "MEDGEN:234979",
          "NCIT:C27850",
          "UMLS:C1336913"
        ],
        "synonyms": [
          "endometrial endometrioid adenocarcinoma with spindled epithelial cells",
          "sarcomatoid uterine corpus endometrioid adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A primary endometrioid adenocarcinoma of the endometrium characterized by the presence of spindled malignant epithelial cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004220"
    },
    {
      "id": 6137,
      "label": "endometrial mixed adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7120
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7664",
          "MEDGEN:1670192",
          "NCIT:C40153",
          "UMLS:C4745252",
          "icd11.foundation:575106861"
        ],
        "synonyms": [
          "endometrial mixed adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the endometrium and is characterized by the presence of both type I and type II endometrial adenocarcinoma components. The minor component constitutes at least 5% of the entire tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004321"
    },
    {
      "id": 7747,
      "label": "endometrial clear cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6742,
        7120
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5299",
          "EFO:1000231",
          "MEDGEN:124655",
          "NCIT:C8028",
          "UMLS:C0279765",
          "icd11.foundation:388735319"
        ],
        "synonyms": [
          "clear cell carcinoma of endometrium",
          "clear cell carcinoma of the endometrium",
          "endometrial clear cell adenocarcinoma",
          "endometrium clear cell adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A clear cell adenocarcinoma that involves the endometrium."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006191"
    },
    {
      "id": 7864,
      "label": "ovarian endometrioid adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4787,
        5685,
        6760,
        7120
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5828",
          "EFO:1000416",
          "GARD:0021893",
          "MEDGEN:91087",
          "NCIT:C7979",
          "ONCOTREE:EOV",
          "Orphanet:454723",
          "SCTID:254852002",
          "UMLS:C0346163"
        ],
        "synonyms": [
          "endometrioid adenocarcinoma of ovary",
          "endometrioid adenocarcinoma of the ovary",
          "endometrioid cancer of ovary",
          "endometrioid cancer of the ovary",
          "endometrioid carcinoma of ovary",
          "endometrioid carcinoma of the ovary",
          "endometrioid ovary carcinoma",
          "endometrium adenocarcinoma of ovary",
          "ovarian endometrioid adenocarcinoma",
          "ovarian endometrioid cancer",
          "ovarian endometrioid carcinoma",
          "ovary endometrium adenocarcinoma",
          "endometrioid ovarian cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An endometrioid adenocarcinoma arising from the ovary. It comprises 10% to 25% of all primary ovarian carcinomas. Grossly, endometrioid carcinoma may present as a cystic or solid mass. Microscopically, the tumor greatly resembles the appearance of the ordinary type of endometrial adenocarcinoma. As a group, endometrioid carcinoma has a prognosis twice as good as that of serous or mucinous carcinoma."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006335"
    }
  ],
  "roots": [
    {
      "id": 4530,
      "label": "endometrial carcinoma"
    },
    {
      "id": 6712,
      "label": "adenocarcinoma"
    }
  ]
}