{
  "id": 7140,
  "label": "colorectal adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005484",
  "properties": {
    "xrefs": [
      "DOID:0050860",
      "DOID:0050914",
      "EFO:0005406",
      "MEDGEN:224904",
      "NCIT:C5673",
      "SCTID:399432003",
      "UMLS:C1302401"
    ],
    "synonyms": [
      "adenoma of large bowel",
      "adenoma of large intestine",
      "adenoma of the large bowel",
      "adenoma of the large intestine",
      "colorectal adenoma",
      "colorectum adenoma",
      "large bowel adenoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An adenoma that arises from the colon or rectum. The group of colorectal adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7022,
      "label": "colorectal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20357,
        21545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0004142",
          "MEDGEN:3171",
          "MESH:D015179",
          "NCIT:C2956",
          "UMLS:C0009404"
        ],
        "synonyms": [
          "colorectal neoplasm",
          "colorectal tumor",
          "colorectal tumour",
          "colorectum neoplasm",
          "colorectum neoplasm (disease)",
          "colorectum tumor",
          "colorectum tumour",
          "large bowel neoplasm",
          "large bowel tumor",
          "large bowel tumour",
          "large intestinal neoplasm",
          "large intestine neoplasm",
          "large intestine tumor",
          "large intestine tumour",
          "neoplasm of colorectum",
          "neoplasm of large bowel",
          "neoplasm of the large bowel",
          "tumor of colorectum",
          "tumor of large bowel",
          "tumor of the large bowel",
          "tumour of colorectum",
          "tumour of large bowel",
          "tumour of the large bowel"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms."
      },
      "child_count": 18,
      "reference_id": "MONDO:0005335"
    },
    {
      "id": 7737,
      "label": "digestive system adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6714,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4147",
          "EFO:1000217",
          "MEDGEN:184920",
          "NCIT:C36207",
          "UMLS:C0948101"
        ],
        "synonyms": [
          "digestive system adenoma",
          "digestive tract adenoma",
          "gastrointestinal adenoma"
        ],
        "definition": "A sporadic or less frequently familial neoplasm, arising from the glandular epithelium of the stomach, small intestine, biliary tract, colon, and rectum. It is a polypoid or flat circumscribed lesion. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. The frequency of malignant transformation depends on the size of the lesion and the degree of dysplasia. Larger adenomas with severe dysplastic changes (sometimes called carcinoma in situ) carry a higher risk of progressing to invasive adenocarcinoma. Gastrointestinal adenomas may present as solitary or multifocal lesions. Familial adenomas tend to be multifocal and carry a higher risk of malignant transformation."
      },
      "child_count": 12,
      "reference_id": "MONDO:0006180"
    }
  ],
  "children": [
    {
      "id": 2975,
      "label": "colon adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7140,
        21434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050912",
          "MEDGEN:1639098",
          "NCIT:C3864",
          "UMLS:C4551463"
        ],
        "synonyms": [
          "adenoma of colon",
          "adenoma of the colon",
          "colon adenoma",
          "colonic adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenoma that arises from the colon. The group of colonic adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0000527"
    },
    {
      "id": 2976,
      "label": "rectum adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7140,
        21431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050915",
          "MEDGEN:266267",
          "NCIT:C5546",
          "SCTID:399730005",
          "UMLS:C1302652"
        ],
        "synonyms": [
          "adenoma of rectum",
          "adenoma of the rectum",
          "rectal adenoma",
          "rectum adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenoma that arises from the rectum. The group of rectal adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis."
      },
      "child_count": 8,
      "reference_id": "MONDO:0000530"
    },
    {
      "id": 7725,
      "label": "colorectal sessile serrated adenoma/polyp",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7140
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000197",
          "MEDGEN:415420",
          "NCIT:C83176",
          "UMLS:C2826783"
        ],
        "synonyms": [
          "colorectal SSA",
          "colorectal SSA/P",
          "colorectal SSP",
          "colorectal mixed hyperplastic adenomatous polyp",
          "colorectal mixed hyperplastic adenomatous polyp/serrated adenoma",
          "colorectal sessile serrated adenoma",
          "colorectal sessile serrated adenoma/polyp",
          "colorectal sessile serrated polyp"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A polyp that arises from the colon or rectum. It is characterized by the presence of serrated glands and the absence of generalized dysplasia. Some authors have suggested that it is a precursor lesion for some colorectal adenocarcinomas with microsatellite instability."
      },
      "child_count": 1,
      "reference_id": "MONDO:0006164"
    },
    {
      "id": 21569,
      "label": "colorectal tubulovillous adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7140,
        21568
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:234165",
          "NCIT:C5675",
          "UMLS:C1333118"
        ],
        "synonyms": [
          "colorectal tubulovillous adenoma",
          "large bowel tubulovillous adenoma",
          "tubulovillous adenoma of large bowel",
          "tubulovillous adenoma of the large bowel"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A neoplasm that arises from the glandular epithelium of the colonic and rectal mucosa. It is characterized by tubular and villous architectural patterns. The neoplastic glandular cells have dysplastic features."
      },
      "child_count": 2,
      "reference_id": "MONDO:0024662"
    }
  ],
  "roots": [
    {
      "id": 7022,
      "label": "colorectal neoplasm"
    },
    {
      "id": 7737,
      "label": "digestive system adenoma"
    }
  ]
}