{
  "id": 7142,
  "label": "tooth agenesis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005486",
  "properties": {
    "xrefs": [
      "DOID:0050591",
      "EFO:0005410",
      "ICD10CM:K00.0",
      "ICD9:520.0",
      "MEDGEN:43794",
      "OMIMPS:106600",
      "Orphanet:2227",
      "Orphanet:99798",
      "SCTID:64969001",
      "UMLS:C0020608",
      "icd11.foundation:1559717619"
    ],
    "synonyms": [
      "hypodontia",
      "selective tooth agenesis",
      "tooth agenesis, selective",
      "oligodontia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      }
    ],
    "definition": "A tooth disease characterized by failure to develop one or more missing teeth."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 8422,
      "label": "tooth disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6893,
        8301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1091",
          "EFO:1001216",
          "MEDGEN:11852",
          "MESH:D014076",
          "NCIT:C35077",
          "SCTID:234947003",
          "UMLS:C0040435"
        ],
        "synonyms": [
          "calcareous tooth disease",
          "calcareous tooth disease or disorder",
          "dental disorder",
          "disease of calcareous tooth",
          "disease or disorder of calcareous tooth",
          "disorder of calcareous tooth",
          "tooth disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "A disease involving the calcareous tooth."
      },
      "child_count": 22,
      "reference_id": "MONDO:0006999"
    }
  ],
  "children": [
    {
      "id": 8541,
      "label": "tooth agenesis, selective, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018244",
          "MEDGEN:483482",
          "OMIM:106600",
          "UMLS:C3489529"
        ],
        "synonyms": [
          "MSX1 tooth agenesis",
          "MSX1-related tooth agenesis with or without orofacial cleft",
          "tooth agenesis caused by mutation in MSX1",
          "tooth agenesis, selective, 1",
          "tooth agenesis, selective, 1, with or without orofacial cleft",
          "tooth agenesis, selective, type 1",
          "STHAG1",
          "hypodontia/oligodontia 1",
          "second premolars and third molars, absence of",
          "tooth agenesis, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Any tooth agenesis in which the cause of the disease is a mutation in the MSX1 gene characterized by varying severity of tooth agenesis that may be seen in combination with orofacial clefting in some individuals."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007129"
    },
    {
      "id": 9217,
      "label": "tooth agenesis, selective, 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142,
        24086
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018245",
          "MEDGEN:372057",
          "MESH:C563634",
          "OMIM:150400",
          "UMLS:C1835492"
        ],
        "synonyms": [
          "WNT10A tooth agenesis",
          "tooth agenesis caused by mutation in WNT10A",
          "tooth agenesis, selective, 4",
          "tooth agenesis, selective, type 4",
          "STHAG4",
          "lateral incisors, absence of",
          "lateral incisors, pegged or missing",
          "succedaneous teeth, agenesis of",
          "tooth agenesis, selective, 4, with or without ectodermal dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Any tooth agenesis in which the cause of the disease is a mutation in the WNT10A gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007881"
    },
    {
      "id": 11881,
      "label": "tooth agenesis, selective, X-linked, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018246",
          "MEDGEN:410143",
          "MESH:C567060",
          "OMIM:313500",
          "UMLS:C1970757"
        ],
        "synonyms": [
          "EDA tooth agenesis",
          "tooth agenesis caused by mutation in EDA",
          "tooth agenesis, selective, X-linked 1, X-linked dominant",
          "tooth agenesis, selective, X-linked, 1",
          "tooth agenesis, selective, X-linked, type 1",
          "STHAGX1",
          "hypodontia/oligodontia, X-linked, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Any tooth agenesis in which the cause of the disease is a mutation in the EDA gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010741"
    },
    {
      "id": 12385,
      "label": "tooth agenesis, selective, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024785",
          "MEDGEN:400679",
          "MESH:C566513",
          "OMIM:602639",
          "UMLS:C1865092"
        ],
        "synonyms": [
          "STHAG2",
          "tooth agenesis, selective, 2",
          "hypodontia/oligodontia 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011265"
    },
    {
      "id": 12579,
      "label": "tooth agenesis, selective, 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018247",
          "MEDGEN:410035",
          "MESH:C567036",
          "OMIM:604625",
          "UMLS:C1970291"
        ],
        "synonyms": [
          "PAX9 tooth agenesis",
          "PAX9-related selective tooth agenesis",
          "STHAG3",
          "hypodontia/oligodontia 3",
          "tooth agenesis caused by mutation in PAX9",
          "tooth agenesis, selective, 3",
          "tooth agenesis, selective, type 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Any tooth agenesis in which the cause of the disease is a mutation in the PAX9 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011477"
    },
    {
      "id": 13630,
      "label": "tooth agenesis, selective, 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018248",
          "MEDGEN:346764",
          "MESH:C565757",
          "OMIM:610926",
          "UMLS:C1858210"
        ],
        "synonyms": [
          "STHAG5",
          "tooth agenesis, selective, 5",
          "he-Zhao deficiency",
          "hypodontia/oligodontia 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012583"
    },
    {
      "id": 15741,
      "label": "tooth agenesis, selective, 7",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018249",
          "MEDGEN:899184",
          "OMIM:616724",
          "UMLS:C4225231"
        ],
        "synonyms": [
          "LRP6 tooth agenesis",
          "STHAG7",
          "tooth agenesis caused by mutation in LRP6",
          "tooth agenesis, selective, 7",
          "tooth agenesis, selective, 7; STHAG7",
          "tooth agenesis, selective, type 7"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Any tooth agenesis in which the cause of the disease is a mutation in the LRP6 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014749"
    },
    {
      "id": 15881,
      "label": "tooth agenesis, selective, 8",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018250",
          "MEDGEN:934697",
          "OMIM:617073",
          "UMLS:C4310730"
        ],
        "synonyms": [
          "STHAG8",
          "WNT10B tooth agenesis",
          "tooth agenesis caused by mutation in WNT10B",
          "tooth agenesis, selective, 8",
          "tooth agenesis, selective, 8; STHAG8",
          "tooth agenesis, selective, type 8"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Any tooth agenesis in which the cause of the disease is a mutation in the WNT10B gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014901"
    },
    {
      "id": 15975,
      "label": "tooth agenesis, selective, 9",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025046",
          "MEDGEN:934605",
          "OMIM:617275",
          "UMLS:C4310638"
        ],
        "synonyms": [
          "GREM2 tooth agenesis",
          "STHAG9",
          "tooth agenesis caused by mutation in GREM2",
          "tooth agenesis, selective, 9",
          "tooth agenesis, selective, 9; STHAG9",
          "tooth agenesis, selective, type 9"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Any tooth agenesis in which the cause of the disease is a mutation in the GREM2 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014999"
    },
    {
      "id": 24260,
      "label": "hypodontia/oligodontia with orofacial cleft",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026267",
          "MEDGEN:369662",
          "UMLS:C1970118"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0100535"
    },
    {
      "id": 24261,
      "label": "tooth agenesis, selective, with orofacial cleft",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026268",
          "MEDGEN:409991",
          "UMLS:C1970117"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0100536"
    },
    {
      "id": 25471,
      "label": "tooth agenesis, selective, 10",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026706",
          "MEDGEN:1824050",
          "OMIM:620173",
          "UMLS:C5774277"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0859339"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 8422,
      "label": "tooth disorder"
    }
  ]
}