{
  "id": 7148,
  "label": "urticaria",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005492",
  "properties": {
    "xrefs": [
      "DOID:1555",
      "EFO:0005531",
      "HP:0001025",
      "ICD10CM:L50",
      "ICD10WHO:L50",
      "ICD9:708",
      "ICD9:708.8",
      "ICD9:708.9",
      "MEDGEN:22587",
      "MESH:D014581",
      "NCIT:C3432",
      "SCTID:126485001",
      "UMLS:C0042109"
    ],
    "synonyms": [
      "hives",
      "urticaria",
      "urticaria (disease)",
      "Urticarias"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 14,
  "parents": [
    {
      "id": 4496,
      "label": "dermatitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2723",
          "ICD9:692.9",
          "MEDGEN:849741",
          "MESH:D003872",
          "NCIT:C2983",
          "SCTID:43116000",
          "UMLS:C3875321"
        ],
        "synonyms": [
          "inflammation of skin",
          "inflammation of the skin",
          "inflammation of zone of skin",
          "inflammatory skin disease",
          "skin inflammation",
          "zone of skin inflammation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An inflammatory process affecting the skin. Signs include red rash, itching, and blister formation. Representative examples are contact dermatitis, atopic dermatitis, and seborrheic dermatitis."
      },
      "child_count": 66,
      "reference_id": "MONDO:0002406"
    }
  ],
  "children": [
    {
      "id": 8013,
      "label": "allergic urticaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6721,
        7148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10612",
          "EFO:1000669",
          "ICD10CM:L50.0",
          "ICD9:708.0",
          "MEDGEN:508394",
          "SCTID:40178009",
          "UMLS:C0149526",
          "Wikipedia:Urticaria#Allergic_urticaria"
        ],
        "synonyms": [
          "allergic form of urticaria",
          "allergic form of urticaria (disease)",
          "allergic urticaria (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A urticaria with a basis in a pathological type I hypersensitivity reaction."
      },
      "child_count": 2,
      "reference_id": "MONDO:0006526"
    },
    {
      "id": 8075,
      "label": "physical urticaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060220",
          "EFO:1000754",
          "MEDGEN:1639813",
          "SCTID:402601007",
          "UMLS:C4551831"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A distinct subgroup of the urticaria that are induced by an exogenous physical stimulus rather than occurring spontaneously."
      },
      "child_count": 3,
      "reference_id": "MONDO:0006599"
    },
    {
      "id": 9297,
      "label": "Melkersson-Rosenthal syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4235,
        4239,
        4370,
        7148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1761",
          "EFO:1001039",
          "GARD:0007010",
          "ICD10CM:G51.2",
          "MEDGEN:6291",
          "MESH:D008556",
          "MedDRA:10027166",
          "NCIT:C84886",
          "NORD:1429",
          "OMIM:155900",
          "Orphanet:2483",
          "UMLS:C0025235"
        ],
        "synonyms": [
          "Melkersson's syndrome",
          "Melkersson-Rosenthal syndrome",
          "MRS",
          "Melkersson syndrome",
          "Mros",
          "cheilitis Granulomatosa"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "The Melkersson-Rosenthal syndrome is a rare disorder characterized by a triad of recurrent orofacial swelling, relapsing facial paralysis and fissured tongue and onset in childhood or early adolescence. It has an estimated incidence of 8/10,000. The etiology is unknown but hereditary predisposition is suspected."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007969"
    },
    {
      "id": 9654,
      "label": "pruritic urticarial papules and plaques of pregnancy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7148,
        21520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009635",
          "ICD10CM:O26.86",
          "ICD9:646.80",
          "ICD9:692.9",
          "MEDGEN:78710",
          "MESH:C535817",
          "MedDRA:10066100",
          "OMIM:178995",
          "Orphanet:64745",
          "SCTID:88697005",
          "UMLS:C0269680",
          "icd11.foundation:968694549"
        ],
        "synonyms": [
          "polymorphic eruption of pregnancy",
          "pruritic urticarial papules and plaques of pregnancy",
          "PUPPP",
          "pruritic urticarial papules and plaques of pregnancy, familial (subtype)",
          "pruritic urticarial papules plaques of pregnancy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008353"
    },
    {
      "id": 9914,
      "label": "urticaria, aquagenic",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7148,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:708.8",
          "MEDGEN:82663",
          "MESH:C562481",
          "OMIM:191850",
          "SCTID:89870006",
          "UMLS:C0263334"
        ],
        "synonyms": [
          "Physical urticaria",
          "urticaria, aquagenic",
          "aquagenic urticaria"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Aquagenic urticaria is a rare condition in which urticaria (hives) develop rapidly after the skin comes in contact with water, regardless of its temperature. It most commonly affects women and symptoms often start around the onset of puberty. Some patients report itching too. It is a form of physical urticaria . The exact underlying cause of aquagenic urticaria is currently unknown. Due to the rarity of the condition, there is very limited data regarding the effectiveness of individual treatments; however, various medications and therapies have been used with variable success."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008632"
    },
    {
      "id": 9916,
      "label": "urticaria, familial localized heat",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7148,
        23867
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:395922",
          "MESH:C566011",
          "OMIM:191950",
          "UMLS:C1860551"
        ],
        "synonyms": [
          "urticaria, familial localized heat"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008634"
    },
    {
      "id": 11639,
      "label": "angioedema",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7148,
        19142
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2716-7007",
          "DOID:1558",
          "EFO:0005532",
          "HP:0100665",
          "ICD9:995.1",
          "MEDGEN:1543",
          "MESH:D000799",
          "SCTID:400075008",
          "UMLS:C0002994"
        ],
        "synonyms": [
          "Edemas, angioneurotic",
          "Quincke edema",
          "Quincke oedema",
          "Quincke's edema",
          "Quincke's oedema",
          "Quinckes edema",
          "Quinckes oedema",
          "Urticarias, giant",
          "angioedemas",
          "angioneurotic Edemas",
          "edema, Quincke's",
          "edema, angioneurotic",
          "giant Urticarias",
          "giant urticaria",
          "urticaria, giant",
          "angioneurotic edema",
          "angioneurotic oedema"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Swelling involving the deep dermis, subcutaneous, or submucosal tissues, representing localized edema. Angioedema often occurs in the face, lips, tongue, and larynx."
      },
      "child_count": 6,
      "reference_id": "MONDO:0010481"
    },
    {
      "id": 16203,
      "label": "drug rash with eosinophilia and systemic symptoms",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        7148,
        7238,
        17704
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013629",
          "ICD10CM:D72.12",
          "MEDGEN:762193",
          "MESH:D063926",
          "MedDRA:10058919",
          "NCIT:C112208",
          "Orphanet:139402",
          "SCTID:702809001",
          "UMLS:C3541994",
          "icd11.foundation:516577496"
        ],
        "synonyms": [
          "DHS",
          "DRESS",
          "DRESS syndrome",
          "Drug hypersensitivity syndrome",
          "Drug reaction with eosinophilia and Systemic symptoms",
          "dress",
          "drug reaction eosinophilic systemic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015340"
    },
    {
      "id": 18936,
      "label": "cutaneous mastocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4409,
        7148,
        9280
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3663",
          "EFO:1000886",
          "GARD:0007842",
          "HP:0200151",
          "ICD10CM:D47.01",
          "ICDO:9740/1",
          "MEDGEN:210143",
          "MESH:D034701",
          "NCIT:C7137",
          "OMIM:154800",
          "ONCOTREE:CMCD",
          "Orphanet:66646",
          "SCTID:397012002",
          "UMLS:C1136033",
          "icd11.foundation:1300710062"
        ],
        "synonyms": [
          "CM",
          "cutaneous (skin) mastocytosis",
          "cutaneous mastocytosis",
          "cutaneous mastocytosis (disease)",
          "mastocytosis, cutaneous",
          "mastocytosis, systemic, somatic",
          "CMCD"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Cutaneous mastocytosis is a term referring to a group of diseases characterized by abnormal accumulation and proliferation of skin mastocytes. In some cases (most commonly in adults), cutaneous mastocytosis may occur in association with mast cell infiltration of various extracutaneous organs, in which case the disorder is referred to as systemic mastocytosis."
      },
      "child_count": 9,
      "reference_id": "MONDO:0019023"
    },
    {
      "id": 20996,
      "label": "cold urticaria",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001881",
          "MEDGEN:472942",
          "SCTID:74774004",
          "UMLS:C0221207",
          "icd11.foundation:915116593"
        ],
        "synonyms": [
          "cold contact urticaria",
          "primary idiopathic cold urticaria",
          "urticaria idiopathic cold"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Cold urticaria is a condition that affects the skin. Signs and symptoms generally include reddish, itchy welts (hives) and/or swelling when skin is exposed to the cold (i.e. cold weather or swimming in cold water). This rash is usually apparent within 2-5 minutes after exposure and can last for 1-2 hours. The exact cause of cold urticaria is poorly understood in most cases. Rarely, it may be associated with an underlying blood condition or infectious disease. Treatment generally consists of patient education, avoiding exposures that may trigger a reaction, and/or medications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0022799"
    },
    {
      "id": 21709,
      "label": "autoimmune urticaria",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7148,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:708.8",
          "MEDGEN:725554",
          "SCTID:402397006",
          "UMLS:C1304191"
        ],
        "synonyms": [
          "autoimmune urticaria",
          "autoimmune urticaria (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "An autoimmune form of urticaria (disease)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0025513"
    },
    {
      "id": 23176,
      "label": "papular urticaria",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7148,
        8092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:78091",
          "MESH:C537169",
          "SCTID:55608001",
          "UMLS:C0263352",
          "icd11.foundation:1014677494"
        ],
        "synonyms": [
          "papular urticaria",
          "prurigo simplex",
          "bullous papular urticaria - type",
          "lichen urticatus",
          "strophulus",
          "urticaria papulosa of hebra"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0043254"
    },
    {
      "id": 23300,
      "label": "idiopathic urticaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7148,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:L50.1",
          "ICD9:708.1",
          "MEDGEN:510411",
          "SCTID:42265009",
          "UMLS:C0157741"
        ],
        "synonyms": [
          "idiopathic angioedema-urticaria"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0044211"
    },
    {
      "id": 25179,
      "label": "chronic urticaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080747",
          "MEDGEN:537829",
          "UMLS:C0263338",
          "icd11.foundation:901000137"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "An urticaria that is characterized by the presence of urticaria for a period exceeding 6 weeks, assuming symptoms for most days of the week."
      },
      "child_count": 1,
      "reference_id": "MONDO:0850230"
    }
  ],
  "roots": [
    {
      "id": 4496,
      "label": "dermatitis"
    }
  ]
}