{
  "id": 7150,
  "label": "triple-negative breast carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0005494",
  "properties": {
    "xrefs": [
      "DOID:0060081",
      "EFO:0005537",
      "MEDGEN:1649548",
      "MESH:D064726",
      "NCIT:C71732",
      "SCTID:706970001",
      "UMLS:C4722518"
    ],
    "synonyms": [
      "triple-negative breast cancer",
      "triple-negative breast carcinoma",
      "triple-receptor negative breast cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "An invasive breast carcinoma which is negative for expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 3025,
      "label": "progesterone-receptor negative breast cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7684
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060078"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0000616"
    },
    {
      "id": 3026,
      "label": "Her2-receptor negative breast cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7684
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060080",
          "EFO:0009780",
          "MEDGEN:1684659",
          "NCIT:C168519",
          "SCTID:431396003",
          "UMLS:C4733095"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0000618"
    },
    {
      "id": 8003,
      "label": "estrogen-receptor negative breast cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7684
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060076",
          "EFO:1000650"
        ],
        "synonyms": [
          "ER- breast cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A subtype of breast cancer that is estrogen-receptor negative"
      },
      "child_count": 1,
      "reference_id": "MONDO:0006513"
    }
  ],
  "children": [
    {
      "id": 6725,
      "label": "basal-like breast carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6698,
        7150
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000281",
          "MEDGEN:770987",
          "NCIT:C53558",
          "UMLS:C3642347"
        ],
        "synonyms": [
          "basal-like breast cancer",
          "basal-like breast carcinoma",
          "basal-like subtype of breast carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A biologic subset of breast carcinoma defined by high expression of genes characteristic of basal epithelial cells, including KRT5 and KRT17, annexin 8, CX3CL1, and TRIM29, and usually by lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is the most common subtype of breast cancer associated with BRCA1 mutations, and is associated with a poor prognosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004984"
    }
  ],
  "roots": [
    {
      "id": 3025,
      "label": "progesterone-receptor negative breast cancer"
    },
    {
      "id": 3026,
      "label": "Her2-receptor negative breast cancer"
    },
    {
      "id": 8003,
      "label": "estrogen-receptor negative breast cancer"
    }
  ]
}